A5011626848- interferon and immune responses
- Climate Change and Health Impacts
- Air Quality and Health Impacts
- Gastric Cancer Management and Outcomes
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Gastrointestinal Tumor Research and Treatment
- COVID-19 Clinical Research Studies
- Metastasis and carcinoma case studies
- Kruppel-like factors research
- Bone Tissue Engineering Materials
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adolescent Sexual and Reproductive Health
- Health disparities and outcomes
- Thermoregulation and physiological responses
- Cancer Immunotherapy and Biomarkers
- Global Cancer Incidence and Screening
- COVID-19 epidemiological studies
- Helicobacter pylori-related gastroenterology studies
- Cancer Cells and Metastasis
- Sleep and related disorders
- Acupuncture Treatment Research Studies
- CAR-T cell therapy research
- Global Health Care Issues
- Nutritional Studies and Diet
Huazhong University of Science and Technology
2016-2025
Peking University People's Hospital
2023-2025
Peking University
2023-2025
Shanxi Medical University
2025
Second Hospital of Shanxi Medical University
2025
Mayo Clinic
2022-2025
Hunan Provincial Maternal and Child Health Hospital
2025
Central South University
2013-2024
Sun Yat-sen University
2022-2024
Shanghai University of Traditional Chinese Medicine
2007-2024
Abstract Background No clinically proven effective antiviral strategy exists for the epidemic Coronavirus Disease 2019 (COVID-19). Methods We conducted a prospective, randomized, controlled, open-label multicenter trial involving adult patients with COVID-19. Patients were randomly assigned in 1:1 ratio to receive conventional therapy plus Umifenovir (Arbidol) (200mg*3/day) or Favipiravir (1600mg*2/first day followed by 600mg*2/day) 10 days. The primary outcome was clinical recovery rate of...
COVID-19 is an ongoing global pandemic. Changes in haematological characteristics patients with are emerging as important features of the disease. We aimed to explore and related risk factors COVID-19.
BCMA-specific chimeric antigen receptor-T cells (CAR-Ts) have exhibited remarkable efficacy in refractory or relapsed multiple myeloma (RRMM); however, primary resistance and relapse exist with single-target immunotherapy. Bispecific CARs are proposed to mitigate these limitations.We constructed a humanized bispecific BM38 CAR targeting BCMA CD38 tested the antimyeloma activity of CAR-Ts vitro vivo. Twenty-three patients RRMM received infusions phase I trial.BM38 showed stronger cytotoxicity...
Background: In addition to supportive therapy, antiviral therapy is an effective treatment for coronavirus disease 2019 (COVID-19). Objective: To compare the efficacy and safety of favipiravir umifenovir (Arbidol) treat COVID-19 patients. Methods: We conducted a prospective, randomized, controlled, open-label multicenter trial involving adult patients with COVID-19. Enrolled initial symptoms within 12 days were randomly assigned in 1:1 ratio receive conventional plus Arbidol (200 mg*3/day)...
Abstract Background Central obesity is thought to be more pathogenic than overall and studies have shown that the association between waist circumference (WC) mortality was strongest in those with a normal body mass index (BMI). The objective of our study determine secular trends prevalence central (WC ≥ 90 cm for men 80 women) among Chinese adults BMI from 1993 2009 examine impact performance combined WC on adults. Methods We used data China Health Nutrition Survey (CHNS) conducted 2009....
Chimeric antigen receptor-modified T-cell (CAR-T) therapy is effective and safe for patients with relapsed/refractory B-cell acute lymphoblastic leukemia (r/r B-ALL), but its value has been limited in terms of long-term leukemia-free survival. New strategies that can help CAR-T achieve lasting effect are urgently warranted. This non-randomized interventional pragmatic clinical trial had a particular aim. It explored whether consolidative allogeneic hematopoietic stem cell transplantation...
Objective: Detection of SARS-CoV-2 by oropharyngeal swabs (OPS) and nasopharyngeal (NPS) is an essential method for coronavirus disease 2019 (COVID-19) management. It not clear how detection rate, sensitivity, the risk exposure medical providers differ in two sampling methods. Methods: In this prospective study, 120 paired NPS OPS specimens were collected from inpatients with confirmed COVID-19. nucleic acid detected real-time RT-PCR. The viral load analyzed regards OPS. Sampling discomfort...
Glia-mediated neuroinflammation is related to brain injury exacerbation after cerebral ischemia/reperfusion (I/R) injury. Astrocytic hemichannels or gap junctions, which were mainly formed by connexin-43, have been implicated in I/R damage. However, the exact roles of astrocytic and junction neuroinflammatory responses induced remain unknown. Primary cultured astrocytes subjected OGD/R injury, an vitro model Salvianolic acid B (SalB) carbenoxolone (CBX) applied for those astrocytes. Besides,...
Abstract Background Stroke, especially ischemic stroke (IS), has been a severe public health problem around the world. However, association between air pollution and remains ambiguous. Methods A total of 63, 997 IS cases aged 18 years or above in Shenzhen were collected from 2008 to 2014. We used time-stratified case-crossover design combining with distributed lag nonlinear model (DLNM) estimate onset. Furthermore, this study explored variability across gender age groups. Results The...
Abstract Background Our objective was to characterize the relationship of anemia and hemoglobin concentrations with cross-sectional cognitive functions changes in over 2 years a large sample Chinese middle aged elderly. Methods Ten thousand nine hundred eighteen adults 45 or older participating China Health Retirement Longitudinal Study (CHARLS) were used for analyses 9324 longitudinal analysis. Cognitive assessed by memory recall (episodic memory), mental status (TICS), global function at...
Ruxolitinib is a selective inhibitor of Jak1/2.Downstream signaling pathways Jak, such as Stat3 and Akt/mTOR, are overactivated contribute to renal interstitial fibrosis.Therefore, we explored the effect on this pathological process.Unilateral ureteral obstruction (UUO) models TGF-β1-treated fibroblasts tubular epithelial cells were adopted in study.Ruxolitinib was administered UUO mice cells.Kidneys from with treatment displayed less injuries compared those without treatment.Ruxolitinib...
Mendelian randomization uses genetic variants as instrumental variables to estimate the causal effect of exposure on outcome from observational data. A common challenge in is that many are only modestly or even weakly associated with interest, a setting known weak instruments. Conventional methods, such popular inverse-variance weighted (IVW) estimator, could be heavily biased toward zero when instrument strength weak. To address this issue, debiased IVW (dIVW) estimator and penalized (pIVW)...
Kernel dehydration rate (KDR) is a crucial production trait that affects mechanized harvesting and kernel quality in maize; however, the underlying mechanisms remain unclear. Here, we identified quantitative locus (QTL), qKDR1, as non-coding sequence regulates expression of qKDR1 REGULATED PEPTIDE GENE (RPG). RPG encodes 31 amino acid micropeptide, microRPG1, which controls KDR by precisely modulating two genes, ZmETHYLENE-INSENSITIVE3-like 1 3, ethylene signaling pathway kernels after...
Abstract The effectiveness of various analytical formulas for estimating R 2 shrinkage in multiple regression analysis was investigated. Two categories were identified: estimators the squared population correlation coefficient (ρ2) and those cross-validity (ρc 2). authors conducted a Monte Carlo experiment to investigate shrinkage, with 4 fully crossed factors (squared coefficient, number predictors, sample size, degree multicollinearity) 500 replications each cell. results indicated that...
The epidemiology of gastroesophageal reflux disease (GERD) has yet to be investigated using the symptomatic threshold criteria recommended by Montreal Definition. This study aimed determine prevalence symptom-defined GERD across five regions China, and investigate variables associated with GERD.A representative sample 18 000 adults (aged 18-80 years) were selected equally from rural urban areas in each region (n = 1800). According Definition, is present when mild symptoms heartburn and/or...