A5101583970- Hormonal Regulation and Hypertension
- Advanced MRI Techniques and Applications
- Adrenal and Paraganglionic Tumors
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Acute Ischemic Stroke Management
- Chronic Lymphocytic Leukemia Research
- MRI in cancer diagnosis
- CAR-T cell therapy research
- PI3K/AKT/mTOR signaling in cancer
- Anesthesia and Pain Management
- Coronary Interventions and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Cardiomyopathy and Myosin Studies
- Blood groups and transfusion
- Advanced Neuroimaging Techniques and Applications
- Reproductive System and Pregnancy
- Surgical Sutures and Adhesives
- HIV/AIDS drug development and treatment
- Gastroesophageal reflux and treatments
- Viral Infectious Diseases and Gene Expression in Insects
- Chronic Myeloid Leukemia Treatments
- Cardiac Arrest and Resuscitation
- Multiple Myeloma Research and Treatments
Sichuan University
2021-2024
West China Hospital of Sichuan University
2021-2024
82th Hospital of Pla
2024
Zhongda Hospital Southeast University
2022-2023
Sun Yat-sen University
2023
Hubei Cancer Hospital
2021
Huazhong University of Science and Technology
2021
Union Hospital
2021
Maternal and Child Health Care Hospital of Bao'an
2019
Jinan University
2019
BCMA-specific chimeric antigen receptor-T cells (CAR-Ts) have exhibited remarkable efficacy in refractory or relapsed multiple myeloma (RRMM); however, primary resistance and relapse exist with single-target immunotherapy. Bispecific CARs are proposed to mitigate these limitations.We constructed a humanized bispecific BM38 CAR targeting BCMA CD38 tested the antimyeloma activity of CAR-Ts vitro vivo. Twenty-three patients RRMM received infusions phase I trial.BM38 showed stronger cytotoxicity...
Background: Early neurological deterioration (END) is not a rare phenomenon in single subcortical infarction (SSI; traditionally known as lacunar infarction) patients. Predictors of END SSI patients are uncertain. Aims: We aimed to investigate the association between infarct lesion characteristics, penetrating artery morphology, carrier plaque features and using whole-brain vessel-wall imaging. Methods: prospectively collected data from without stenosis corresponding artery. The size...
Endometriosis is a common gynecologic disorder with enigmatic etiopathogenesis and characterized by tumor-like biological behaviors. Epithelial-mesenchymal transition (EMT) has been recognized as core mechanism of endometriosis. Recently, circular RNAs (circRNAs) have attracted considerable attention because they play an important role in the progression cancer. However, little known about function circRNAs This study intended to investigate involvement microRNAs process EMT ovarian...
The clinical application of coronary MR angiography (MRA) remains limited due to its long acquisition time and often unsatisfactory image quality. A compressed sensing artificial intelligence (CSAI) framework was recently introduced overcome these limitations, but feasibility in MRA is unknown.To evaluate the diagnostic performance noncontrast-enhanced with CSAI patients suspected artery disease (CAD).Prospective observational study.A total 64 consecutive (mean age ± standard deviation [SD]:...
Aldosterone- and cortisol-coproducing adrenal adenoma (A/CPA) cases have been observed in patients with primary aldosteronism (PA). This study investigated the incidence, clinical characteristics, molecular biological features of A/CPAs. We retrospectively identified 22 A/CPA from 555 PA who visited Chinese People’s Liberation Army General Hospital between 2004 2015. Analysis parameters revealed that A/CPAs had larger tumors than those pure APAs (<mml:math...
Drug overdose deaths, including those due to prescription opioids, represent a critical public health issue in the United States and worldwide. Artificial intelligence (AI) approaches have been developed deployed help prescribers assess patient's risk for overdose-related death, but it is unknown whether experts can leverage similar predictions make local resource allocation decisions more effectively. In this work, we evaluated how AI-based assessment could be used inform using working...
Vacuum assisted closure (VAC) is an effective treatment that promotes wound healing in clinical practice. However, the pain caused by VAC dressing removal still a challenge for patients and medical staff. The purpose of this study was to investigate analgesic effect safety premixed nitrous oxide/oxygen removal. This single center, randomized, placebo-controlled, double-blind trial. A total 100 requiring were recruited randomly divided into intervention group control group. will receive...
MYC/BCL2/BCL6 triple-hit lymphoma (THL) is an uncommon subset of high-grade B-cell with aggressive clinical behavior and poor prognosis. TP53 mutation independently progonistic indicator in patients THL, hence novel therapeutic strategies are needed for these patients. CD19-directed chimeric antigen receptor(CAR19)-T cell therapy has shown promising efficacy relapsed/refractory diffuse large B (RR DLBCL), but the majority CAR19-T products to date have been manufactured using viral vectors....
This study used cardiac magnetic resonance imaging (MRI) to compare the characteristics of left ventricular remodeling in patients with primary aldosteronism (PA) those essential hypertension (EH) and healthy controls (HCs).This prospective enrolled 35 PA, addition age- sex-matched EH, HCs, all whom underwent comprehensive clinical MRI examinations. The analysis variance was detect differences among three groups. Univariable multivariable linear regression analyses were determine...
KCNJ5 mutation is a major cause of aldosterone-producing adenomas (APAs). The development APA apart from less investigated. To investigate other mechanisms affecting aldosterone secretion KCNJ5. Six pairs KCNJ5-mutated, high and low aldosterone–secreting APAs, five non–KCNJ5-mutated four normal adrenal glands were assayed by Affymetrix GeneChip Human Transcriptome Array 2.0. A total 113 samples investigated to explore the expression glutathione-S-transferase A1 (GSTA1). H295R cells used...
BACKGROUND:This article presents our experience in managing a rare kidney tumor – reninoma by analyzing relatively large series of cases from single center. MATERIAL AND METHODS:Nine were reviewed. Clinical manifestations, imaging examinations, laboratory perioperative data, and pathological findings summarized. A 58.8-month follow-up was performed to evaluate patient survival recrudescence. RESULTS:The main clinical manifestations hypertension, hypokalemia, headache, dizziness, nausea,...
Angiotensin receptor neprilysin inhibitor (ARNI) sacubitril-valsartan has been recommended as one of the first-line therapies in heart failure with reduced ejection fraction. However, whether ARNI could benefit patients ST-segment elevation myocardial infarction (STEMI) by improving left ventricular (LV) remodeling remains unknown. The primary objective PERI-STEMI trial is to assess more effective preventing adverse LV for STEMI than enalapril.
This study used routine cardiac function parameters and strain based on magnetic resonance imaging to evaluate the effects of specific treatments left ventricular structure in patients with PA. We found that PA had lower LV volumes myocardial mass, as well improved circumferential longitudinal motion both after adrenalectomy drug treatment. Specific treatment can not only effectively relieve clinical symptoms, but also improve subclinical dysfunction.
To assess the relationship between left ventricular remodeling parameters of cardiac magnetic resonance and NT-pro-BNP in patients with primary aldosteronism (PA).
To investigate the longitudinal changes in left ventricular (LV) structure and function after bariatric surgery obese individuals their relationship with preoperative ejection fraction (LVEF) by cardiac magnetic resonance (CMR) imaging. We prospectively enrolled 75 subjects scheduled for laparoscopic sleeve gastrectomy 46 age sex-matched healthy controls (the control group). All underwent CMR examination to obtain LV structural parameters, LVEF, strain parameters. According were divided into...
Abstract Recent WHO vaccination guidance no longer recommends COVID-19 beyond the first booster in low risk population, citing high population-level hybrid immunity due to widespread omicron infections. 1 Although SARS-CoV-2 infection confers durable protection against reinfection, 2-4 it may also produce immune imprinting, which skews subsequent response variant antigens toward first-exposed antigen based on antigenic distance. 5,6 China has earliest and exclusively...