A5043563691- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Connexins and lens biology
- Peripheral Neuropathies and Disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Traditional Chinese Medicine Analysis
- Neuroscience and Neural Engineering
- Planarian Biology and Electrostimulation
- Anesthesia and Neurotoxicity Research
- Neurological Disease Mechanisms and Treatments
- Cardiac Ischemia and Reperfusion
- Advanced battery technologies research
- Epilepsy research and treatment
- Hereditary Neurological Disorders
- Conducting polymers and applications
- Inflammatory Myopathies and Dermatomyositis
- Dermatology and Skin Diseases
- Genetics and Neurodevelopmental Disorders
- Electromagnetic Compatibility and Measurements
- Yersinia bacterium, plague, ectoparasites research
- Plant and Biological Electrophysiology Studies
- Fetal and Pediatric Neurological Disorders
- Nerve injury and regeneration
- Fatty Acid Research and Health
- RNA modifications and cancer
Jilin University
2017-2024
First Hospital of Jilin University
2017-2024
Health Commission of Jilin Province
2019
Shanghai University
2018
First Bethune Hospital of Jilin University
2017
Glia-mediated neuroinflammation is related to brain injury exacerbation after cerebral ischemia/reperfusion (I/R) injury. Astrocytic hemichannels or gap junctions, which were mainly formed by connexin-43, have been implicated in I/R damage. However, the exact roles of astrocytic and junction neuroinflammatory responses induced remain unknown. Primary cultured astrocytes subjected OGD/R injury, an vitro model Salvianolic acid B (SalB) carbenoxolone (CBX) applied for those astrocytes. Besides,...
Abstract Bioelectronic patches hold promise for patient‐comfort wound healing providing simplified clinical operation. Currently, they face paramount challenges in establishing long‐term effective electronic interfaces with targeted cells and tissues due to the inconsistent energy output high bio interface impedance. Here a new electrochemical stimulation technology is reported, using simple patch, which integrates efficient generation delivery of stimulation. This realized by employing...
The prolonged wound-healing process caused by pathogen infection remains a major public health challenge. developed electrical antibiotic administration typically requires metal electrodes wired to continuous power supply, restricting their use beyond clinical environments. To obviate the necessity for antibiotics and an external source, we have wearable synergistic electroceutical device composed of air self-charging Zn battery. This battery integrates sustained tissue regeneration...
Stroke is the second leading cause of death worldwide and most common adult-acquired disability in many nations. Thus, attenuating damage after ischemic injury improving patient prognosis are great importance. We have indicated that preconditioning (IP) can effectively reduce ischemia reperfusion inhibition gap junctions may further this damage. Although we confirmed function closely associated with glutamate, did not investigate mechanism. In present study, aimed to clarify whether blockade...
A biocompatible and fully erodible PEDOT derivative is reported. An implanted rechargeable Zn–polymer battery demonstrates high rate capacity full biodegradation in vivo .
Connexin-43 (Cx43) is the most abundant gap junction protein in nervous system. It enables cell communication and has important physiological roles including ion transport substrate exchange, all of which have been implicated cerebral ischemia injury. Our previous vitro vivo studies demonstrated that Cx43 internalized degraded during stress. However, significance ischemia-induced degradation remains unclear. Herein, we injury mediated by selective autophagy; additionally, identified two...
It remains an urgent need for early recognition of disease severity, treatment option and outcome Guillain-Barré syndrome (GBS). The chief complaint may be quickly obtained in clinic is one the candidates predictors. However, studies on are still lacking GBS. aim study to describe components complaints GBS patients, explore association between severity/treatment option/outcome GBS, so as aid prediction course assist clinicians prescribe optimal treatment. A total 523 patients admitted First...
Salvianolic acids (SA) has been widely used for the treatment of acute cerebral infarction (ACI) combined with basic western medicine therapy in China. This study was aimed to evaluate efficacy and safety SA on ACI its influence neurological functions, activity daily living, cognitive functions.We retrieved related articles from PubMed, Cochrane Center Controlled Trials Register, EMBASE, Medline, Ovid, Chinese National Knowledge Infrastructure, Biomedical Literature Database, Wanfang...
Pathogenic variation of the MECP2 gene presents mostly as Rett syndrome in females and is extremely rare males. Most male patients with mutation show duplication syndrome.Here we report a case 10-month-old boy hemizygous insertion NM_001110792, c.799_c.800insAGGAAGC, which results frameshift (p.R267fs*6). The patient presented severe encephalopathy neonatal period, accompanied by development backwardness, hypotonia, ocular oropharyngeal dyskinesia. This first this mutation, highlights...
The aim of this study was to determine the associations between serum folate level and clinical course severity Guillain-Barré syndrome (GBS). We retrospectively enrolled 112 pairs GBS patients age- sex-matched healthy controls with measured levels. On admission, 21 (18.9%) had deficiency, which only two were female patients. Patients normal levels a shorter disease progression than those deficiency (median duration: 6 versus 13 days, p < 0.001). Serum on admission correlated duration...
Objective The objective of this study was to better understand the clinical features photosensitive epilepsy (PSE) in Chinese children. Methods Thirty-one children with PSE were screened out 398 who consecutively diagnosed by video-electroencephalogram (VEEG) monitoring method and using an intermittent photic stimulation (IPS) test. Their EEGs retrospectively analyzed, their treatment outcomes followed up. Results accounted for 7.79% (31/398) during observation period our single center. male...
Accurately representing the spatial location of amygdaloid body can lay an anatomical basis for neurosurgery operation amputation through lateral fissure approach. As we know, there are a number nerve nucleuses and essential structures locating around in our brain, especially optic tract. However, only few research had been done to protect these tissues or nucleuses. Thus, reconstructed three-dimensional images human brain established coordinate system. The morphological parameters data were...
Accurately obtaining the field distribution inside radome is very important for study of performance. By converting into a current distribution, it easy to improve design radome, detect manufacturing errors, and verify numerical simulations. In this paper, analyzes equivalent from near-field data its surface, i.e., transformation. The transformation based on surface integral representation that associates with near data. Fourier transform (FFT) singular value decomposition (SVD) are used...
Abstract Background : Connexin 43 (Cx43) are the most widely distributed gap junction proteins in nervous system. Cx43 enables cell-to-cell communication and plays an important role ion transport, substrate exchange delivery of information , which have been implicated cerebral ischemia injury. Our previous work revealed relationships between glia-mediated neuroinflammation through release ATP oxygen-glucose deprivation (OGD), means degradation may improve neuroinflammatory damage during OGD...