A5100335171- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Cancer, Stress, Anesthesia, and Immune Response
- RNA Interference and Gene Delivery
- Epilepsy research and treatment
- Curcumin's Biomedical Applications
- Pharmacological Effects of Natural Compounds
- Dementia and Cognitive Impairment Research
- Immune cells in cancer
- Glycosylation and Glycoproteins Research
- Cancer Cells and Metastasis
- Advanced Nanomaterials in Catalysis
- Ferroptosis and cancer prognosis
- Inflammasome and immune disorders
- Nerve injury and regeneration
- interferon and immune responses
- Phagocytosis and Immune Regulation
- Genetics and Neurodevelopmental Disorders
- Multiple Myeloma Research and Treatments
- Invertebrate Immune Response Mechanisms
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Glioma Diagnosis and Treatment
- Single-cell and spatial transcriptomics
- Macrophage Migration Inhibitory Factor
Hangzhou First People's Hospital
2023-2025
Zhejiang Chinese Medical University
2025
Westlake University
2025
University of California, San Diego
2024
Zhejiang University
2023-2024
Chinese Academy of Fishery Sciences
2023
Fudan University Shanghai Cancer Center
2016-2023
Ministry of Agriculture and Rural Affairs
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2023
Sanya University
2023
Abstract The heart, which is the first organ to develop, highly dependent on its form function 1,2 . However, how diverse cardiac cell types spatially coordinate create complex morphological structures that are crucial for heart remains unclear. Here we integrated single-cell RNA-sequencing with high-resolution multiplexed error-robust fluorescence in situ hybridization resolve identity of develop human heart. This approach also provided a spatial mapping individual cells enables...
Summary: Purpose: Severe myoclonic epilepsy in infancy (SMEI) is a distinct syndrome. Patients with borderline SMEI (SMEB) are subgroup clinical features similar to those of core but not necessarily consistent the accepted diagnostic criteria for SMEI. The aim this study was delineate genetic correlation between and SMEB estimate frequency mutations both phenotypes. Methods: We examined 96 healthy volunteers 58 unrelated individuals whose were either (n = 31) or 27). screened abnormalities...
Recent research studies have shown that the low survival rate of liver cancer is due to drug resistance and metastasis. In tumor microenvironment (TME), activated hepatic stellate cells (aHSCs) been proven favor development cancer. Hence, combination therapy dual-targeting aHSCs might be an effective strategy for treatment this study, novel multifunctional liposomes (CAPS-CUR/GA&Gal-Lip) were prepared co-delivery curcumin (CUR) capsaicin (CAPS), in which glycyrrhetinic acid (GA) galactose...
Abstract Nanotechnology is revolutionizing cancer therapy, and catalyzes the emerging of ion‐involved cancer‐therapeutic modality, which unfortunately suffers from undesirable nanocarriers for efficient intracellular ion delivery. To radically extricate this critical issue, glutathione (GSH)‐responsive organosilica network employed to lock liquid drops at nanoscale via a general bottom‐up strategy achieve systemic delivery “ion drugs”. In work, sulfate radical generation donor (Na 2 S O 8 ),...
Background: Tumor microenvironment (TME) plays a vital role in the development of hepatocellular carcinoma (HCC). Mounting evidence indicates that peripheral nerves could induce shift from quiescent hepatic stellate cells (HSCs) to cancer-associated fibroblasts (CAFs) by secreting substance P (SP). The anti-tumor strategy targeting "SP-HSCs-HCC" axis might be an effective therapy inhibit tumor growth and metastasis. Objective: In this study, we prepared novel liposomes (CUR-APR/HA&GA-LPs)...
Abstract Phototherapy, including photodynamic therapy (PDT) and photothermal (PTT), has great promise in the treatment of cancer. However, there are many obstacles that can restrict therapeutic efficacy phototherapy. The hypoxic tumor microenvironment production reactive oxygen species (ROS) PDT. As for PTT, thermotolerance cancer cells may lead to ineffective PTT. In this study, IR780 glycolysis inhibitor lonidamine (LND)-encapsulated liposomes prepared hepatocellular carcinoma. be used as...
Recent efforts have been focused on combining two or more therapeutic approaches with different mechanisms to enhance antitumor therapy. Moreover, nanosize drug-delivery systems for codelivering drugs proapoptotic and antiangiogenic activities exhibited great potential in efficient treatment of cancers.Glycyrrhetinic acid (GA)-modified liposomes (GA LPs) liver-targeted codelivery curcumin (Cur) combretastatin A4 phosphate (CA4P) were prepared characterized. In vitro cellular uptake,...
Combination therapy based on nano-sized drug delivery system has been developed as a promising strategy by combining two or more anti-tumor mechanisms. Here we prepared liver-targeted nanoparticles (GH-DPP) composed of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol-polyetherimide (DSPE-PEG-PEI) with Glycyrrhetinic acid-modified hyaluronic acid (GA-HA) for co-delivery doxorubicin (DOX) and Bcl-2 siRNA. Particles size, zeta potential morphology were determined the...
Cancer-associated fibroblasts (CAFs) are a major component of the tumor microenvironment (TME). In hepatocellular carcinoma (HCC), quiescent hepatic stellate cells (HSCs) could be activated to become CAFs, which play critical role in progression and drug resistance. Therefore, recent efforts have been focused on combining anti-HSC pro-apoptotic activities improve anti-tumor efficacy drugs. this study, glycyrrhetinic acid hyaluronic acid–modified liposomes (GA-HA-Lip) were prepared for...
Despite the emergence of innovative cancer treatment strategies, global burden imposed by malignant glioma is expected to increase; thus, new approaches for treating disease are urgently required. Dopamine, a monoamine catecholamine neurotransmitter, currently regarded as an important endogenous regulator tumor growth. Dopamine may play role in treatment; however, mechanism underlying anti-tumor activity dopamine remains poorly understood. Here, we explored potential roles and highlight...
The tumor-targeting ability and pH-sensitive properties of intelligent drug delivery systems are crucial for effective anti-tumor therapy.In this study, sHA-DOX/HA-GA mixed micelles were designed with the following properties: sulfated hyaluronic acid (sHA) was synthesized to block cell migration by inhibiting HAase; sHA-DOX conjugates via hydrazone bond realize DOX-sensitive release. introduction HA-GA conjugate could improve active-targeting cellular uptake.The results showed that...
Propofol is a common sedative-hypnotic drug used for general anesthesia. Recent studies have drawn attention to the antitumor effects of propofol, but potential mechanism by which propofol suppresses colon cancer stemness and epithelial-mesenchymal transition (EMT) has not been fully elucidated.