A5086475368- Nanoparticle-Based Drug Delivery
- Immune cells in cancer
- Graphene and Nanomaterials Applications
- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- RNA Research and Splicing
- Circular RNAs in diseases
- Glycosylation and Glycoproteins Research
- Cancer, Hypoxia, and Metabolism
- Phagocytosis and Immune Regulation
- Cancer-related molecular mechanisms research
- Curcumin's Biomedical Applications
- Inflammatory Biomarkers in Disease Prognosis
Huazhong University of Science and Technology
2024
Weifang Medical University
2021-2022
Weifang University of Science and Technology
2022
Qinghai University Affiliated Hospital
2022
Weifang University
2021
Recent research studies have shown that the low survival rate of liver cancer is due to drug resistance and metastasis. In tumor microenvironment (TME), activated hepatic stellate cells (aHSCs) been proven favor development cancer. Hence, combination therapy dual-targeting aHSCs might be an effective strategy for treatment this study, novel multifunctional liposomes (CAPS-CUR/GA&Gal-Lip) were prepared co-delivery curcumin (CUR) capsaicin (CAPS), in which glycyrrhetinic acid (GA) galactose...
IRI&398-s-LPs was destroyed in the TME, leading to rapid release of drugs, thus killing tumor cells and CAFs simultaneously. The combinational strategy by eliminating both “seeds” “soil” is beneficial for enhancing antitumor effect.
The present study is aimed to investigate the regulatory effects and related mechanism of long non-coding RNA testis-specific transcript, Y-linked 15 (TTTY15) in gastric carcinoma (GC) cell proliferation, migration, invasion, apoptosis epithelial–mesenchymal transition (EMT). TTTY15 expression GC tissue samples cells was detected by quantitative real-time PCR (qRT-PCR), correlation between clinicopathological indicators analyzed. Cell counting kit-8 (CCK-8), BrdU, flow cytometry Transwell...
In the tumor microenvironment (TME), cross-talk between cells and hepatic stellate (HSCs) could facilitate drug resistance metastasis, leading to poor prognosis in patients with hepatocellular carcinoma (HCC). Herein, blocking would be an effective antitumor strategy. this study, nanoscale dual-ligand-modified multifunctional liposomes (CMDLs) were prepared for codelivery of curcumin metformin. To mimic a real TME, "HSC + HCC" cell cocultured model "m-HSC–HCC" coimplanted established...