A5020022966- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Antibiotic Resistance in Bacteria
- Optical measurement and interference techniques
- RNA modifications and cancer
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Use and Resistance
- Clinical Laboratory Practices and Quality Control
- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 detection and testing
- MicroRNA in disease regulation
- Long-Term Effects of COVID-19
- Bacterial Identification and Susceptibility Testing
- Renal function and acid-base balance
- Biosensors and Analytical Detection
- Advanced Measurement and Metrology Techniques
- Immune Response and Inflammation
- Metabolomics and Mass Spectrometry Studies
- Urinary Tract Infections Management
- COVID-19 diagnosis using AI
- Trace Elements in Health
- Structural Health Monitoring Techniques
- Autophagy in Disease and Therapy
- Advanced biosensing and bioanalysis techniques
- Platelet Disorders and Treatments
First Hospital of Jilin University
2016-2025
Jilin University
2016-2025
Third Affiliated Hospital of Sun Yat-sen University
2025
Sun Yat-sen University
2025
Peking University
2022-2024
Anhui Normal University
2024
Central South University
2024
Affiliated Hospital of Hebei University
2022-2023
Hebei University of Chinese Medicine
2022-2023
Chengdu University of Information Technology
2023
Abstract Circular RNAs (circRNAs) were shown to play an important role in the occurrence and progression of tumors. However, functions nuclear genome-derived circRNAs localized mitochondria tumor cells remain largely elusive. Here, we report that circPUM1, a circular RNA derived from back-splicing pre-mRNAs genome PUM1, localizes mitochondria. The expression level circPUM1 is positively correlated with HIF1α accumulation under CoCl 2 -induced intracellular hypoxic-like condition esophageal...
Infertility is a common complication in diabetic men, mainly due to the loss of germ cells by apoptotic cell death. However, effective and safe approaches prevent induction testicular apoptosis for patients have not been available. Resveratrol (RSV), group compounds called polyphenols from plants, has indicated its promising used clinically cancers cardiovascular diseases. Therefore, present study aimed determining whether RSV attenuates type 1 diabetes (T1D)-induced death mouse model. We...
The distinction between mild pathogenic mtDNA mutations and population polymorphisms can be ambiguous because both are homoplasmic, alter conserved functions, correlate with disease. One possible explanation for this ambiguity is that the same variant may have different consequences in contexts. NADH dehydrogenase subunit 1 (ND1) nucleotide 3394 T > C (Y30H) such a case. This has been associated Leber hereditary optic neuropathy it reduces complex I activity cellular respiration 7% 28% on...
Abstract We have shown cardiac protection by metallothionein (MT) in the development of diabetic cardiomyopathy (DCM) via suppression cell death cardiac‐specific MT‐overexpressing transgenic (MT‐TG) mice. The present study was undertaken to define whether diabetes can induce endoplasmic reticulum (ER) stress and MT prevent attenuating ER stress. Diabetes induced streptozotocin both MT‐TG wild‐type (WT) Two weeks, 2 5 months after onset, detected expression chaperones, apoptosis...
Acute lung injury (ALI) is a devastating disease, which characterized by diffuse endothelium, epithelial damage, and increased pulmonary capillary permeability. Recent data have suggested that the circulating endothelial progenitor cells (EPCs) play an important role in repair after vascular injury. This study was undertaken to investigate possible endothelial-repairing effects of EPC transplantation LPS-induced ALI rats. Using Y-chromosome situ hybridization reverse transcription polymerase...
A novel spring-assisted hybrid nanogenerator (HG) was developed for harvesting low-frequency vibration energy, which enabled us to develop a self-powered safety system and power LEDs, drive some electronic devices.
The effect of magnesium (Mg) deficiency on the prevalence diabetes and diabetic complications has received a great attention. present study investigated association Mg level in serum or urine patients, lived Northeast areas China, with either pre-diabetes without complications. From January 2010 to October 2011, patients type 1 (T1D, n = 25), 2 (T2D, 137), impaired fasting glucose (IFG, 12) tolerance (IGT, 15), age/gender matched control (n 50) were enrolled First Hospital Jilin University....
This study investigated the association of copper and zinc levels in serum or urine patients living northeast China, with either prediabetes diabetes. From January 2010 to October 2011, type 1 diabetes (T1D,<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>25</mml:mn></mml:mrow></mml:math>), 2 (T2D,<mml:math id="M2"><mml:mrow><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>137</mml:mn></mml:mrow></mml:math>), impaired fasting...
Coronavirus disease 2019 (COVID-19) is a current global health threat caused by SARS-CoV-2. The innate immune response such as type I IFN (IFN-I) the first line of host defense against viral infections, whereas SARS-CoV-2 proteins antagonize IFN-I production through distinct mechanisms.
Acute lung injury (ALI) is characterized by severe inflammation and damage to the air-blood barrier, resulting in respiratory function life-threatening outcomes. Macrophage polarization plays an essential role occurrence, development, outcome of ALI. As drug carriers, self-assembled DNA nanostructures can potentially overcome drawbacks limitations traditional anti-inflammatory agents owing their nontoxicity, programmability, excellent structural control at nanoscale. A small interfering RNA...
Abstract High performance imaging in parallel cameras is a worldwide challenge computational optics studies. However, the existing solutions are suffering from fundamental contradiction between field of view (FOV), resolution and bandwidth, which system speed FOV decrease as scale increases. Inspired by compound eyes mantis shrimp zoom cameras, here we break these bottlenecks proposing deep learning-based (DLBP) camera, with an 8-μrad instantaneous 4 × at 30 frames per second. Using DLBP...
Non-nucleotide stimulators of interferon gene (STING) agonists hold promise as immunotherapeutic agents for postsurgical adjuvant treatment tumors. However, their limited effect duration hampers therapeutic effectiveness, necessitating prolonged administration multiple doses that heightens infection risk and impacts patient compliance. Here, we develop an implantable dual-drug depot in a sandwich-like configuration, with non-nucleotide STING agonist (MSA-2) the outer layers 3D-printed...
To assess the risk factors associated with H. pylori infection in urban Chinese population. The study was conducted from March to November 2023, including 12,902 participants aged 18-60 years across 52 cities distributed over 26 provinces China. Risk included socioeconomic status, lifestyles, and public understanding. Univariate multivariate logistic regression analysis used calculate corrected odds ratios (ORs) 95% confidence intervals (CIs). According regression, significantly higher rates...
Severe Mycoplasma pneumoniae pneumonia (SMPP) poses significant diagnostic challenges due to its clinical features overlapping with those of other common respiratory diseases. This study aims develop and validate machine learning (ML) models for the early identification SMPP risk prediction liver heart damage in using accessible laboratory indicators. Cohort 1 was divided into group diseases group. 2 myocardial damage, non-damage groups. The built five ML algorithms were compared screen best...
An advanced iterative algorithm is presented to extract phase distribution from randomly and spatially nonuniform phase-shifted interferograms. The proposed divides the interferograms into small blocks retrieves local shifts accurately by iterations. Therefore, can be calculated with high precision eliminating effect of tilts occurring during shifting. Simulated results experiments demonstrate that exhibits converges faster than previous algorithms even when tilt errors are up 27.6% normal step.
An advanced spatial carrier phase-shifting (SCPS) algorithm based on least-squares iteration is proposed to extract the phase distribution from a single interferogram. The divides interferogram into four phase-shifted interferograms. By compensating for effects of variations shifts between pixels and background contrast, determines local simultaneously accurately. Numerical simulations show that accuracy obviously improved by contrast variations. peak valley residual error remains less than...
This retrospective study evaluated trends and association between resistance of Pseudomonas aeruginosa isolated from patients with hospital-acquired infections (HAIs) hospital antimicrobial usage 2003 through 2011 in a tertiary care northeast China. HAI was defined as occurrence infection after admission, without evidence that present or incubating (≦48 h) on admission. In vitro susceptibilities were determined by disk diffusion test susceptibility profiles using zone diameter interpretive...