A5101671400- Inflammatory Biomarkers in Disease Prognosis
- Wheat and Barley Genetics and Pathology
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Phytase and its Applications
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- Receptor Mechanisms and Signaling
- Genomics, phytochemicals, and oxidative stress
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Tea Polyphenols and Effects
- Telomeres, Telomerase, and Senescence
- Edible Oils Quality and Analysis
- Liver Disease Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Phytoestrogen effects and research
- Histone Deacetylase Inhibitors Research
- PARP inhibition in cancer therapy
- MicroRNA in disease regulation
- Molecular Biology Techniques and Applications
- Ferroptosis and cancer prognosis
Washington University in St. Louis
2020-2025
Guangxi Medical University
2017-2025
First Affiliated Hospital of GuangXi Medical University
2017-2024
Zhejiang University
2024
Hangzhou First People's Hospital
2024
First People's Hospital of Nanning
2022-2023
Tianjin University
2022
Sichuan Agricultural University
2007-2022
Army Medical University
2012-2022
Xinqiao Hospital
2012-2022
Estrogen receptor-α (ERα)-negative breast cancer is clinically aggressive and normally does not respond to conventional estrogen target-directed therapies. The soybean isoflavone, genistein (GE), has been shown prevent inhibit recent studies have suggested that GE can enhance the anticancer capacity of an antagonist, tamoxifen (TAM), especially in ERα-positive cells. However, role ERα-negative remains unknown.We evaluated vitro vivo epigenetic effects on ERα reactivation by using MTT assay,...
Abstract Matrix stiffening is a prominent feature of pulmonary fibrosis. In this study, we demonstrate that matrix stiffness regulates the ability fibrotic lung myofibroblasts to invade basement membrane (BM). We identify α 6 -integrin as mechanosensing integrin subunit mediates stiffness-regulated myofibroblast invasion. Increasing -expression, specifically B isoform (α B), couples β 1 mediate MMP-2-dependent pericellular proteolysis BM collagen IV, leading Human idiopathic fibrosis express...
Breast cancer is one of the most lethal diseases in women; however, precise etiological factors are still not clear. Genistein (GE), a natural isoflavone found soybean products, believed to be potent chemopreventive agent for breast cancer. One important mechanisms GE inhibition may involve its potential impacting epigenetic processes allowing reversal aberrant events during tumorigenesis. To investigate regulation impedance tumorigenesis, we monitored alterations several key tumor-related...
Advanced-stage ovarian cancer is characterized by high mortality due to development of resistance conventional chemotherapy. Novel compounds that can enhance the efficacy chemotherapy in may overcome this drug resistance. Consumption green tea (epigallocatechin gallate, EGCG) and cruciferous vegetables (sulforaphane, SFN) inversely associated with occurrence has anticancer effects through targeting multiple molecules cells. However, EGCG SFN combinational treatment on cells cisplatin these...
Background: The clinicopathological and prognostic relevance of neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte (PLR), monocyte/lymphocyte (MLR) in non-muscular invasive bladder cancer (NMIBC) was investigated. Methods: All patients who underwent transurethral resection tumor (TURBT) postoperative intravesical chemotherapy had their peripheral blood levels NLR, PLR, MLR quantified. preoperative were analyzed with G1, G2, G3 NMIBC. A total 208 divided into poor prognosis (PP,...
Acute lung injury (ALI) is characterized by severe inflammation and damage to the air-blood barrier, resulting in respiratory function life-threatening outcomes. Macrophage polarization plays an essential role occurrence, development, outcome of ALI. As drug carriers, self-assembled DNA nanostructures can potentially overcome drawbacks limitations traditional anti-inflammatory agents owing their nontoxicity, programmability, excellent structural control at nanoscale. A small interfering RNA...
Aims In the cancer-related research field, there is currently a major need for greater number of valuable biomarkers to predict prognosis hepatocellular carcinoma (HCC). this study, we aimed screen hub genes related immune cell infiltration and explore their prognostic value HCC. Methods We analyzed five datasets (GSE46408, GSE57957, GSE74656, GSE76427, GSE87630) from Gene Expression Omnibus database differentially expressed (DEGs). A protein–protein interaction network DEGs was constructed...
Ovarian cancer is a major cause of death among gynecological cancers and its etiology still unclear. Currently, the two principle obstacles in treating this life threatening disease are lack effective biomarkers for early detection drug resistance after initial chemotherapy. Similar to other cancers, initiation development ovarian characterized by disruption oncogenes tumor suppressor genes both genetic epigenetic mechanisms. While it well known that challenging treat through strategy due...
// Huaping Chen 1, * , Siyuan Shan Li Zhijian 1 Xuan Zhu Meiyu Dai Lingxi Kong Xiaodan Lv Zhili Huang and Xue Qin Department of Clinical Laboratory, First Affiliated Hospital Guangxi Medical University, Nanning 530021, Guangxi, China These authors contributed equally to this work should be considered as co-first Correspondence to: Qin, email: qinxue919@126.com Keywords: des-gamma-carboxyprothrombin, AFP, hepatocellular cancer, diagnosis, meta-analysis Received: June 22, 2017 Accepted: July...