A5101593272- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Pregnancy and preeclampsia studies
- Cancer-related molecular mechanisms research
- Glycosylation and Glycoproteins Research
- Birth, Development, and Health
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- DNA Repair Mechanisms
- Cancer-related Molecular Pathways
- Folate and B Vitamins Research
- Hepatitis C virus research
- Inflammatory Biomarkers in Disease Prognosis
- Circular RNAs in diseases
- Reproductive System and Pregnancy
- Glutathione Transferases and Polymorphisms
- Monoclonal and Polyclonal Antibodies Research
- Systemic Lupus Erythematosus Research
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- MicroRNA in disease regulation
- Biosensors and Analytical Detection
- Galectins and Cancer Biology
Guangxi Medical University
2016-2025
First Affiliated Hospital of GuangXi Medical University
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Ministry of Agriculture and Rural Affairs
2025
Northwest A&F University
2025
Xi'an University of Science and Technology
2023-2024
Lanzhou University
2023-2024
First Hospital of Lanzhou University
2023-2024
Northeast Agricultural University
2020-2024
Qingdao Eighth People's Hospital
2024
Highlights•SIRT5 desuccinylates and activates PKM2•Lys311 is a key succinylated site in the regulation of PKM2 activity•Sirt5 blocks IL-1β production LPS-activated macrophages by regulating PKM2•SIRT5 plays an important role inhibiting inflammationSummaryLPS-activated undergo metabolic shift from dependence on mitochondria-produced ATP to reliance aerobic glycolysis, where critical determinant. Here, we show that physiological substrate SIRT5 SIRT5-regulated hypersuccinylation inhibits...
Epidemiological studies demonstrate a clear association of adverse intrauterine environment with an increased risk ischemic heart disease in adulthood. Hypoxia is common stress to the fetus and results decreased protein kinase C epsilon (PKCepsilon) expression cardiac vulnerability ischemia reperfusion injury adult offspring rats.The present study tested hypothesis that fetal hypoxia-induced methylation cytosine-phosphate-guanine dinucleotides at PKCepsilon promoter repressive contributes...
Interleukin (IL)-18 gene polymorphisms have been found to play multiple roles in various diseases. However, studies focused on its involvement hepatocellular carcinoma (HCC) remains controversial, and no much study has taken IL-18 serum levels into consideration. This investigates the association between risk of hepatitis B virus-related HCC their impact levels. A total 153 patients 165 healthy controls were enrolled this study. Polymorphisms at positions −607C/A −137G/C determined using...
The present study tested the hypothesis that protein kinase C (PKC) ϵ plays a key role in sex dichotomy of heart susceptibility to ischemia and reperfusion injury adult offspring resulting from prenatal hypoxic exposure. Time-dated pregnant rats were divided between normoxic (10.5% O<sub>2</sub> on days 15–21 gestation) groups. Hearts 3-month-old progeny subjected (I/R) Langendorff preparation. Preischemic values left ventricle (LV) function same control animals. Prenatal hypoxia...
Triglyceride (TG) is a complex phenotype influenced by both genetic and environmental factors. Recent genome-wide association studies (GWAS) have identified genes or loci affecting lipid levels; however, such in Chinese populations are limited. A two-stage GWAS were conducted to identify variants that associated with TG population of 3495 men. Gene–environment interactions on serum levels further investigated for the seven single nucleotide polymorphisms (SNPs) studied stages. Two previously...
<h3>Objective</h3> Tumour biomarkers are used as indicators for cancer screening and predictors therapeutic responses prognoses in patients. We aimed to identify genetic loci that influence concentrations of antigen 19-9 (CA19-9), carcinoembryonic (CEA) α fetoprotein (AFP), investigated the associations between significant single nucleotide polymorphisms (SNPs) with risks oesophageal squamous cell (OSCC), pancreatic hepatocellular cancers. <h3>Design</h3> carried out a genome wide...
Plasma lipid levels are important risk factors for cardiovascular disease and influenced by genetic environmental factors. Recent genome wide association studies (GWAS) have identified several lipid-associated loci, but these loci been primarily in European populations. In order to identify markers a Chinese population analyze the heterogeneity between Europeans Asians, especially Chinese, we performed meta-analysis of two on four common traits including total cholesterol (TC), triglycerides...
Bladder cancer (BCa) threatens human health due to the high occurrence and mortality. Nowadays, more researchers focussed on molecular mechanisms biological functions of miRNAs in cancers. The present study aims role miR-454-3p miR-374b-5p BCa. expression levels were detected BCa tissues cell lines by qRT-PCR analysis. Kaplan-Meier analysis revealed that positively correlated with overall survival (OS) rate patients. Gain-of-function assays conducted demonstrate inhibitory effects invasion,...
Macrophage lipid metabolism plays a pivotal role in innate and adaptive immune responses. Previous studies have shown that this process infections contributes to the pathogenesis of diabetes, atherosclerosis, other immunometabolic diseases. M1 macrophages, or classically activated are key players defense against bacterial infections. M2 alternatively involved anti-inflammatory Using multiple reaction monitoring method, we identified changes composition during differentiation human murine...
Arachidonic acid metabolites are a family of bioactive lipids derived from membrane phospholipids.