A5101953191- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Nanocluster Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Carbon and Quantum Dots Applications
- Radioactive element chemistry and processing
- Molecular Sensors and Ion Detection
- Electrochemical Analysis and Applications
- Enterobacteriaceae and Cronobacter Research
- Analytical chemistry methods development
- DNA and Nucleic Acid Chemistry
- RNA Interference and Gene Delivery
- Gold and Silver Nanoparticles Synthesis and Applications
- Pain Mechanisms and Treatments
- Luminescence Properties of Advanced Materials
- SARS-CoV-2 detection and testing
- Asymmetric Hydrogenation and Catalysis
- Carbon dioxide utilization in catalysis
- Nanoplatforms for cancer theranostics
- Bacteriophages and microbial interactions
- Luminescence and Fluorescent Materials
- Trace Elements in Health
- Protein Structure and Dynamics
- Metal-Organic Frameworks: Synthesis and Applications
- Molecular spectroscopy and chirality
University of South China
2014-2025
Changsha University of Science and Technology
2025
West China Medical Center of Sichuan University
2024-2025
National Tsing Hua University
2009-2024
Southern University of Science and Technology
2023-2024
National Center for Nanoscience and Technology
2024
Sichuan University
2024
West China Hospital of Sichuan University
2024
Renji Hospital
2018-2023
Shanghai Jiao Tong University
2018-2023
Abstract Touch and itch sensations are crucial for evoking defensive emotional responses, light tactile touch may induce unpleasant (mechanical or alloknesis). The neural substrate touch-to-itch conversion in the spinal cord remains elusive. We report that interneurons expressing Tachykinin 2-Cre ( Tac2 Cre ) receive direct Aβ low threshold mechanoreceptor (LTMR) input form monosynaptic connections with GRPR neurons. Ablation inhibition markedly reduces mechanical but not acute chemical nor...
Direct hydroalkylation of ynazoles, facilitating the efficient synthesis linear N‐β‐vinylazoles, is accomplished through functionalization sp3 C‐H bonds using trace amounts dioxygen as an initiator. This reagent‐free method eliminates need for exogenous reagents and proceeds a radical chain mechanism involving dual hydrogen atom transfer (HAT) processes. Its application potential exemplified implementation scale‐up operations.
Abstract: Nitrogen-containing heterocycles, such as indoles and quinolines, serve the key scaffolds in numerous pharmaceuticals, pesticides, natural products. The synthesis methods of nitrogen-containing heterocycles show significant scientific industrial value. As a chemical intermediate featuring dual functional groups, cyanamide plays crucial role organic synthesis, directly affecting development new drugs design materials. Particularly heterocyclic compounds, cyano group can introduce...
The histone deacetylase inhibitor MS275 (Entinostat) demonstrates anti-tumor effects against various types of solid tumors in vitro. But its effectiveness clinical trials is limited. underlying reasons remain to be determined. purpose this study was explore how enhance the colorectal cancer (CRC). Our data showed that inhibited CRC cell proliferation and induced apoptosis, irrespective gene mutation status. However, did not effectively suppress tumor growth AOM-DSS model as observed...
Four new α-methylene-γ-lactone-bearing cembranoids, 20-acetylsinularolide B (6), presinularolide (7), 3-dehydroxylpresinularolide (8), and 3-dehydroxyl-20-acetylpresinularolide (9), together with five known analogues, sinularolides B−E (1−4) C (5), were isolated from a South China Sea soft coral Lobophytum crassum. Their structures relative stereochemistry established by combination of detailed spectroscopic data analysis chemical correlations. The 1−9 further confirmed an X-ray diffraction...
Composites of gold nanomaterials and imaging agents show promise in cancer therapy.
Based on the Sustainable Development Goals and competitiveness index, an evaluation index system for sustainable development of tourism cities was established. The level 221 outstanding in 2018 evaluated, their paths were designed accordingly. results show following: (1) There is a large gap scores. In general, no city has achieved strong model. Natural cultural resources protection systems are shortcomings systems. (2) weights natural largest, endowment, degree infrastructure construction,...