A5084888054- Marine Sponges and Natural Products
- Microbial Natural Products and Biosynthesis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthetic Organic Chemistry Methods
- Synthesis and Biological Activity
- Chemical synthesis and alkaloids
- Seaweed-derived Bioactive Compounds
- Traditional and Medicinal Uses of Annonaceae
- Bioactive Compounds and Antitumor Agents
- Coral and Marine Ecosystems Studies
- Natural product bioactivities and synthesis
- Marine Biology and Environmental Chemistry
- Protein Tyrosine Phosphatases
- Crystallography and molecular interactions
- Echinoderm biology and ecology
- Carbohydrate Chemistry and Synthesis
- Molecular spectroscopy and chirality
- Phytochemical compounds biological activities
- Bioactive Natural Diterpenoids Research
- Advanced Synthetic Organic Chemistry
- Phytochemical Studies and Bioactivities
- Plant biochemistry and biosynthesis
- Chemical Synthesis and Analysis
- Marine Toxins and Detection Methods
Shanghai University
2023-2025
Advanced Research Institute
2022-2025
Shanghai Institute of Materia Medica
2015-2024
Chinese Academy of Sciences
2015-2024
Zhejiang University of Technology
2018-2024
State Key Laboratory of Drug Research
2006-2024
Nanjing University of Chinese Medicine
2020-2024
Shanghai Ninth People's Hospital
2024
University of Chinese Academy of Sciences
2017-2023
Qingdao National Laboratory for Marine Science and Technology
2018-2023
Two indole alkaloids, phidianidines A (1) and B (2), exhibiting an uncommon 1,2,4-oxadiazole ring linked to the system, have been isolated from marine opisthobranch mollusk Phidiana militaris. The structures of two metabolites elucidated by spectroscopic techniques. Phidianidines exhibit high cytotoxicity against tumor nontumor mammalian cell lines in vitro assays.
Soft corals of the genus Sinularia are one most widespread soft corals. They a rich source bioactive substances with intriguing and unique structural features. The present paper reviews latest progress in chemistry pharmacological activities terpenoids from provides perspective on future areas research interest.
Abstract Benzoxepane derivatives were designed and synthesized, one hit compound emerged as being effective in vitro with low toxicity. In vivo, this ameliorated both sickness behavior through anti‐inflammation LPS‐induced neuroinflammatory mice model cerebral ischemic injury anti‐neuroinflammation rats subjected to transient middle artery occlusion. Target fishing for the using photoaffinity probes led identification of PKM2 target protein responsible anti‐inflammatory effect compound....
Five new cembrane-type diterpenes, lobocalines A–E (1–5), and four steroids, lobocaloids A–D (9–12), along with six known related compounds (6–8 13–15) were isolated from the Yalong Bay soft coral Lobophytum catalai Tixier-Durivault. The structures of elucidated by extensive spectroscopic analysis, NMR calculation DP4+ time-dependent density functional theory–electronic circular dichroism (TDDFT-ECD) calculations, X-ray diffraction analyses comparison reported data compounds. Further, aid...
Biflorane diterpenoids are unique natural products often seen in marine animals. Recent studies have reported a small number of biflorane synthases. However, the catalytic mechanism and structural basis for formation remain unclear. To address these issues, we conducted genome mining terpene synthases from sea whip coral Paramuricea clavata , resulting discovery synthase Pc TS1. We performed series isotope labeling, crystallography, quantum mechanics/molecular mechanics calculations,...
Methyl sarcotroates A and B (3 4), two unprecedented diterpenoids possessing a tetradecahydrocyclopenta[3′,4′]cyclobuta[1′,2′:4,5]cyclonona[1,2-b]oxirene ring system, along with their probable biogenetic precursor, sarcophytonolide M (1), were isolated from the Hainan soft coral Sarcophyton trocheliophorum. Their structures elucidated by detailed spectroscopic analysis, absolute configuration of compound 3 was determined TDDFT ECD calculations. Compound 4 exhibited significant inhibitory...
Three new diterpenes, xishacorenes A–C, featuring an undescribed bicyclo[3.3.1]nonane nucleus bearing 1-vinyl and 13-[(E)-4-methylpenta-1,3-dien-1-yl] alkyl chains, a related monocyclic known compound, were isolated from the Xisha soft coral Sinularia polydactyla. The structures of including their absolute configurations, elucidated by extensive spectroscopic analysis TDDFT ECD calculations. compounds exhibit interesting dose-dependent promotion effect on ConA-induced T lymphocyte...
A novel diterpenoid, sarcomililate (1), possessing a previously undescribed tricyclo[11.3.0.02,16]hexadecane scaffold, along with two new cembranoids, sarcomililatols and B (2 3), known related diterpenoids (4 5), was isolated from the Hainan soft coral Sarcophyton mililatensis. The complete chemical structure including absolute configuration (AC) of 1 unambiguously determined by combination residual dipolar coupling (RDC)-based NMR analysis, TDDFT-ECD (ECD = electronic circular dichroism)...
Two new macrocyclic cembranoids were isolated from the South China Sea soft coral Lobophytum sp. Quantum mechanical–nuclear magnetic resonance (QM–NMR) methods decisive in their structural elucidation. Better performance arriving at definitive structures was obtained by QM–NMR upon incorporation of 3JHH values. The validity this approach also supported an alternative conformational proposal versus that X-ray crystallography.
The chemical investigation of the South China Sea soft coral Sinularia humilis has resulted in isolation a library diverse diterpenoids, including four new cembranoids, namely, humilisins A–D (1–4), two uncommon diterpenoids possessing tetradecahydrocyclopenta[3′,4′]cyclobuta[1′,2′:4,5]cyclonona[1,2-b]oxirene ring system, E and F (5 6), eight known related compounds (7–14). Humilisin A (1) is first cembranoid with an ether linkage between C-3 C-7. structures absolute configurations 1–8 were...
Abstract Eunicellane diterpenoids, containing a typical 6,10-bicycle, are bioactive compounds widely present in marine corals, but rarely found bacteria and plants. The intrinsic macrocycle exhibits innate structural flexibility resulting dynamic conformational changes. However, the mechanisms controlling remain unknown. discovery of terpene synthase, MicA, that is responsible for biosynthesis nearly non-flexible eunicellane skeleton, enable us to propose feasible theory about structures....
A series of nine casbane diterpenes, compounds 5−13, exhibiting either cis or trans ring junctions were isolated from the Hainan soft coral Sinularia depressa. The structures this group compounds, basic member which was named depressin (5), established by detailed spectroscopic analysis. In addition, absolute configuration main metabolite, 10-hydroxydepressin (7), and its epimer, 1-epi-10-hydroxydepressin (8), determined a combination conformational analysis modified Mosher's method....