A5080001817- Marine Sponges and Natural Products
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Microbial Natural Products and Biosynthesis
- Traditional and Medicinal Uses of Annonaceae
- Cannabis and Cannabinoid Research
- Chemical synthesis and alkaloids
- Synthetic Organic Chemistry Methods
- Malaria Research and Control
- Essential Oils and Antimicrobial Activity
- Sesquiterpenes and Asteraceae Studies
- GABA and Rice Research
- Phytochemicals and Antioxidant Activities
- Synthesis and Biological Activity
- Plant biochemistry and biosynthesis
- Synthesis and Catalytic Reactions
- Bioactive natural compounds
- Bioactive Compounds and Antitumor Agents
- Bioactive Natural Diterpenoids Research
- Phytochemical compounds biological activities
- Seaweed-derived Bioactive Compounds
- Marine Toxins and Detection Methods
- Plant Toxicity and Pharmacological Properties
- Natural Antidiabetic Agents Studies
- Plant chemical constituents analysis
University of Naples Federico II
2015-2024
University of Milan
2010-2020
University of Illinois Chicago
2018
Istituto Nazionale di Fisica Nucleare, Sezione di Napoli
2015-2018
Collaborative Research Group
2018
Simon Fraser University
2018
Robert Bosch (Australia)
2017
The University of Sydney
2017
Camden and Campbelltown Hospitals
2017
Western Sydney University
2017
The California bay laurel or Umbellularia californica (Hook. & Arn.) Nutt., is known as the 'headache tree' because inhalation of its vapours can cause severe headache crises. However, underlying mechanism precipitating properties unknown. monoterpene ketone umbellulone, major volatile constituent leaves californica, has irritating properties, and a reactive molecule that rapidly binds thiols. Thus, we hypothesized umbellulone stimulates transient receptor potential ankyrin 1 channel in...
Speed trap: Cysteamine reacts in DMSO with electrophilic double bonds to afford Michael adducts (see scheme), whereas no trapping reaction takes place apolar solvents. A simple and quick NMR spectroscopic method identify acceptors sort them into reversible irreversible thiol sinks is validated biologically a cellular assay sensitive thiol-trapping agents. DMSO=dimethyl sulfoxide. Detailed facts of importance specialist readers are published as "Supporting Information". Such documents...
This research was aimed at investigating the essential oil production, chemical composition and biological activity of a crop pink flowered oregano (Origanum vulgare L. subsp. L.) under different spatial distribution plants (single binate rows). plant factor shown to affect its growth, soil covering, fresh biomass, amount composition. In particular, percentage higher for row treatment full bloom. The oils obtained by hydrodistillation fully characterized GC GC-MS. from grown in single rows...
Doxorubicin is a highly active antineoplastic agent, but its clinical use limited because of cardiotoxicity. Although nutraceuticals endowed with anti-inflammatory properties exert cardioprotective activity, their bioavailability and stability are inconsistent. In an attempt to address this issue, we evaluated whether bioavailable nanoemulsions loaded (curcumin fresh dry tomato extracts rich in lycopene) protect cardiomyoblasts (H9C2 cells) from doxorubicin-induced toxicity. Nanoemulsions...
An extensive phytochemical analysis of the polar extracts from bulbs shallot, Allium ascalonicum Hort., led to isolation two new furostanol saponins, named ascalonicoside A1/A2 (1a/1b) and B (4), respectively, along with compounds 2a 2b, most likely extraction artifacts. On basis 2D NMR mass spectrometry data, structures novel were elucidated as furost-5(6)-en-3β,22α-diol 1β-O-β-d-galactopyranosyl 26-O-[α-l-rhamnopyranosyl-(1→2)-O-β-d-glucopyranoside] (1a), its epimer at position 22 (1b),...
In the present study,13 bromopyrrole alkaloids, including oroidin analogs hymenidin (2), dispacamide B (3) and D (4), stevensine (5) spongiacidin (6), their derivatives lacking imidazole ring bromoaldisin (7), longamide (8) A (9), dimeric sceptrin (10) dibromopalau’amine (11), non-oroidin bromopyrrolohomoarginin (12), manzacidin (13), agelongine (14), obtained from marine sponges belonging to Axinella Agelas generahave been screened in vitro against four parasitic protozoa, i.e., two...
A novel pyrrolizidine alkaloid, penibruguieramine (1), characterized by an unprecedented 1-alkenyl-2-methyl-8-hydroxymethylpyrrolizidin-3-one skeleton, was isolated from the endophytic fungus Penicillium sp. GD6, associated with Chinese mangrove Bruguiera gymnorrhiza. The absolute configuration of (1) established TDDFT ECD calculations vacuum and solution conformers, exploiting transitions lactam chromophore. plausible pathway for its biosynthesis has been proposed.
Further investigation of the Caribbean marine sponge Agelas dispar for biologically active constituents has led to isolation novel bromopyrrole alkaloids longamide B (1), and clathramides C (2) D (3), whose structures have been determined by spectroscopic methods. Isolation known keramadine (4) ecdysonic sterols ecdysterone (5) ajugasterone (6) is also reported. The antimicrobial activities isolated summarized.
Two rotenoids isolated from Boerhaavia diffusa (Nyctaginaceae), boeravinones G (1) and H (2), have been found to potently inhibit the drug efflux activity of breast cancer resistance protein (BCRP/ABCG2), a multidrug transporter responsible for cell chemotherapy. The isolation nine additional rotenoid derivatives (3−11), including new I (10) J (11), extract B. roots allowed us establish structure−activity relationships toward inhibition BCRP-mediated transport activity. results show positive...