A5038339229- Advancements in Transdermal Drug Delivery
- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- 3D Printing in Biomedical Research
- Polymer Surface Interaction Studies
- Pickering emulsions and particle stabilization
- Lipid Membrane Structure and Behavior
- Gold and Silver Nanoparticles Synthesis and Applications
- Microfluidic and Capillary Electrophoresis Applications
- Electrospun Nanofibers in Biomedical Applications
- Proteins in Food Systems
- Nanoplatforms for cancer theranostics
- Supramolecular Self-Assembly in Materials
- biodegradable polymer synthesis and properties
- Coenzyme Q10 studies and effects
- Advanced Sensor and Energy Harvesting Materials
- Nanoparticles: synthesis and applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- RNA Interference and Gene Delivery
- Nanocluster Synthesis and Applications
- Microfluidic and Bio-sensing Technologies
- Surfactants and Colloidal Systems
- Cellular Mechanics and Interactions
- Advanced biosensing and bioanalysis techniques
- Biochemical effects in animals
Italian Institute of Technology
2015-2024
Center for Advanced Biomaterials for Healthcare
2015-2024
Centro Interuniversitario di Ricerca sui Peptidi Bioattivi
2014-2022
University of Naples Federico II
2016-2022
Istituto Nazionale di Fisica Nucleare, Sezione di Napoli
2017-2021
National Institute of Optics
2014
STMicroelectronics (Italy)
2008-2009
IBM Research - Zurich
2009
Microneedle (MN) patches consisting of miniature needles have emerged as a promising tool to perforate the
Doxorubicin is a highly active antineoplastic agent, but its clinical use limited because of cardiotoxicity. Although nutraceuticals endowed with anti-inflammatory properties exert cardioprotective activity, their bioavailability and stability are inconsistent. In an attempt to address this issue, we evaluated whether bioavailable nanoemulsions loaded (curcumin fresh dry tomato extracts rich in lycopene) protect cardiomyoblasts (H9C2 cells) from doxorubicin-induced toxicity. Nanoemulsions...
Transdermal drug delivery represents an appealing alternative to conventional administration systems. In fact, due their high patient compliance, the development of dissolvable and biodegradable polymer microneedles has recently attracted great attention. Although stamp-based procedures guarantee tip resolution reproducibility, they have long processing times, low levels system engineering, are a source possible contaminants, thermo-sensitive drugs cannot be used in conjunction with them....
Abstract Transdermal microneedle patches have attracted significant attention in the medical arena over last decade as alternatives to traditional drug delivery methods. Microneedle are capable of delivering their payloads using burst‐ and sustained‐release mechanisms, or response internal/external triggers, optimize therapeutic potency. Herein, release mechanisms profiles reviewed, along with impact cargo on cytotoxicity efficacy. The potential applications microneedles transdermal...
Hypodermic needle injection is still the most common method of drug delivery despite its numerous limitations and drawbacks, such as pain, one‐shot administration, risk infection. Seeking a viable, safe, pain‐free alternative to over 16 billion injections per year has therefore become top priority for our modern technological society. Here, system that uses pyroelectric cartridge in lieu syringe piston potential solution discussed. Upon stimulation, electro‐draws, at room temperature, an...
The blood brain barrier (BBB) represents a challenge in the development of new nano-delivery systems able to reach central nervous system (CNS). In order test efficacy these nanocarriers, it is fundamental use vitro models that resemble vivo cell culture conditions. Here, we demonstrate for first time ability membranotropic peptide, namely gH625, transport cargo-acting as shuttle-across BBB layer under flow conditions mimic rate. To this aim, microfluidic device was designed based on...
Deflection of magnetic beads in a microfluidic channel can be improved through viscoelastic focusing.
The bioimpedances of tissues beyond the stratum corneum, which is outermost layer skin, contain crucial clinical information. Nevertheless, bioimpedance measurements both viable skin and adipose tissue are not widely used, mainly because complex multilayered structure electrically insulating nature corneum. Here, a theoretical framework established for analyzing impedances and, in particular, skin. Then, strategies determined system-level design electrodes electronics, minimize 4-wire (or...
Abstract Natural polymers have found increased use in a wider range of applications due to their less harmful effects. Notably, bacterial cellulose has gained significant consideration its exceptional physical and chemical properties substantial biocompatibility, which makes it an attractive candidate for several biomedical applications. This study attempts thoroughly unravel the microstructure precursors, known as bioflocculants, date been poorly characterised, by employing both electron...
The key role of nanocarriers in improving the pharmacological properties commonly used drugs is recognized worldwide. It also known that development new effective use targeting moieties integrated on their surface essential. Herein, we propose a nanocarrier based an oil water nanoemulsion coated with membranotropic peptide derived from glycoprotein H Herpes simplex virus 1, as gH625, order to reduce endolysosomal accumulation and enhance cytosolic localization. In addition, show enhanced...
CoenzymeQ10 (CoQ10) is a well-known antioxidant and anti-inflammatory agent with cardioprotective properties. However, clinical trials based on its oral administration have failed to provide significant effect cardiac functionality. The main limitation of CoQ10 very low bioavailability instability that limit dramatically effects as agent. Herein, we loaded in high bioavailable nano-emulsions (NEs) coated chitosan or hyaluronic acid order improve performance.We tested hepatoprotective...
Escherichia coli filamentous bacteriophages (M13, f1, or fd) have attracted tremendous attention from vaccinologists as a promising immunogenic carrier and vaccine delivery vehicle with vast possible applications in the development of vaccines. The use fd bacteriophage an antigen system is based on modification display technology. In particular, it designed to express multiple copies exogenous peptides (or polypeptides) covalently linked viral capsid proteins. This study for first time...
Biodegradable polymer microneedles (MNs) are recognized as non-toxic, safe and stable systems for advanced drug delivery cutaneous treatments, allowing a direct intradermal in some cases controlled release. Most of the found literature fabricated by micromolding, which is multistep thus typically costly process. Due to industrial needs, mold-free methods represent very intriguing approach microneedle fabrication. Electro-drawing (ED) has been recently proposed an alternative fast, mild...
In materials science, there is a considerable interest in the fabrication of highly engineered biomaterials that can interact with cells and control their shape. particular, from literature, role played by physical cell confinement cellular structural organization thus regulation its functions has been well-established. this context, addition dynamic feature to physically confining platforms aiming at reproducing vitro well-known interaction between microenvironment would be desirable. To...