A5076579423- 3D Printing in Biomedical Research
- Cancer Cells and Metastasis
- Tissue Engineering and Regenerative Medicine
- Cellular Mechanics and Interactions
- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- Wound Healing and Treatments
- Additive Manufacturing and 3D Printing Technologies
- Cystic Fibrosis Research Advances
- Skin Protection and Aging
- Biomedical Ethics and Regulation
- Advancements in Transdermal Drug Delivery
- Neonatal Respiratory Health Research
- Dermatologic Treatments and Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Cervical Cancer and HPV Research
- Pancreatic function and diabetes
- Nanoparticle-Based Drug Delivery
- Pluripotent Stem Cells Research
- Planarian Biology and Electrostimulation
- Collagen: Extraction and Characterization
- Advanced Fluorescence Microscopy Techniques
- Tracheal and airway disorders
- biodegradable polymer synthesis and properties
- Digestive system and related health
University of Naples Federico II
2006-2024
Center for Advanced Biomaterials for Healthcare
2013-2023
Italian Institute of Technology
2008-2023
John Wiley & Sons (United States)
2018-2019
Hudson Institute
2018-2019
Istituto Nazionale di Fisica Nucleare, Sezione di Napoli
2016-2018
National Research Council
2008-2012
In this work, a new model of breast cancer is proposed featuring both epithelial and stromal tissues arranged on microfluidic chip. The main task the work in vitro replication activation during tumor invasion. stroma its morphological/compositional changes play key role progression. Despite emerging evidences, to date has not been achieved yet. tumor-on-chip built order replicate features native counterpart: multicellularity (tumor cell cell); 3D engineered compartment composed...
Transdermal drug delivery represents an appealing alternative to conventional administration systems. In fact, due their high patient compliance, the development of dissolvable and biodegradable polymer microneedles has recently attracted great attention. Although stamp-based procedures guarantee tip resolution reproducibility, they have long processing times, low levels system engineering, are a source possible contaminants, thermo-sensitive drugs cannot be used in conjunction with them....
Intestine-Liver-on-chip systems can be useful to predict oral drug administration and first-pass metabolism in vitro order partly replacing the animal model. While organ on chip technology count sophisticated micro-physiological devices, engineered used still remain artificial surrogates of native counterparts. Here, we a bottom-up tissue engineering strategy build-up physiologically functional 3D Human Intestine Model (3D-HIM) as well Liver-microtissues (HepG2-mTPs) designed microfluidic...
Abstract An intestine‐on‐chip has been developed to study intestinal physiology and pathophysiology as well transport absorption toxicity studies in a controlled human similar environment. Here, we report that dynamic culture of an enhances extracellular matrix (ECM) remodeling the stroma, basement membrane production speeds up epithelial differentiation. We three‐dimensional stromal equivalent composed subepithelial myofibroblasts embedded their own ECM. Then, cultured colon...
In this study, a novel micrometric biomaterial acting as cyclic oxygen releasing system is designed. Human hemoglobin (Hb) conjugated to the surface of gelatin microspheres (GM) produce depot (G-HbOD). G-HbOD obtained by means two different conjugation strategies. The degree GM surfaces in terms free amino groups using HPLC first evaluated. By following strategy A (G-HbOD_A), Hb formation polyurethane linker. B (G-HbOD_B) occurs via amide bound formation. Physical and morphological...
The advent of 3D bioprinting technologies in tissue engineering has unlocked the potential to fabricate
The fabrication of functional tissue units is one the major challenges in engineering due to their vitro use tissue-on-chip systems, as well modular for construction macrotissue analogs. In this work, we aim engineer dermal micromodules obtained by culturing human fibroblasts into porous gelatine microscaffold. We proved that such stromal cells coupled with microscaffolds are able synthesize and assemble an endogenous extracellular matrix (ECM) resulting micromodules, which evolve...
There is a growing interest for developing organotypic cervical models by using primary cells that are able to reproduce the physiological relevant stromal microenvironment and distinctive histology of native epithelium. Here first time it reported production an model featured scaffold-free tissue resembling extracellular matrix (ECM) composition organization counterpart as well completely well-differentiated To reach this aim, human microtissue precursors have been produced, characterized,...