Five new cembrane-type diterpenes, lobocalines A–E (1–5), and four steroids, lobocaloids A–D (9–12), along with six known related compounds (6–8 13–15) were isolated from the Yalong Bay soft coral Lobophytum catalai Tixier-Durivault. The structures of elucidated by extensive spectroscopic analysis, NMR calculation DP4+ time-dependent density functional theory–electronic circular dichroism (TDDFT-ECD) calculations, X-ray diffraction analyses comparison reported data compounds. Further, aid...

A chemical investigation of the soft coral Lobophytum sp. and sponge Xestospongia from South China Sea led to isolation five steroids, including two new compounds (1 4) one known natural product (3). Compounds 1–3 were derived sp., while 4 5 obtained The structures these determined by extensive spectroscopic analysis, time-dependent density functional theory–electronic circular dichroism (TDDFT-ECD) calculation method, comparison with spectral data previously reported in literature....

The chemical investigation of Et2O (Diethyl ether)‐soluble partition the acetone extract soft coral Sinularia sp. collected off Ximao Island, has led to isolation and characterization two new cembranoids (1 2), along with one known related analogue (3). structures absolute configurations 1 2 were elucidated through extensive spectroscopic analysis time‐dependent density functional theory‐electronic circular dichroism (TDDFT‐ECD) calculations. Antioxidant capacity those isolated compounds was...

Six previously undescribed methyl ester cembranoids, namely sarcoehrenolides L–Q (1–6), along with three known related ones (7–9), were isolated from the soft coral Sarcophyton ehrenbergi collected off Weizhou Island in South China Sea. Their structures and absolute configurations unambiguously established light of extensive spectroscopic data analysis, X-ray diffraction chemical conversion, TDDFT-ECD calculations. All compounds evaluated via vitro bioassays to investigate their...

As lung cancer remains the leading cause of cancer‐related deaths worldwide, development novel therapeutic drugs is essential. 20‐Acetylsinularolide B (ASB) a diterpene isolated from marine soft coral Lobophytum crassum. Our previous studies demonstrated that ASB exhibits growth‐inhibitory effects on non‐small cell (NSCLC) cells. This study employed network pharmacology to predict ASB's potential targets in NSCLC treatment. The predicted target was validated using cellular thermal shift...

The present investigation of the South China Sea soft coral Sarcophyton trocheliophorum resulted in discovery six new polyoxygenated diterpenes, namely sartrocheliols A–E (1, 3, 5–8) along with four known ones, 2, 4, 9, and 10. Based on extensive spectroscopic data analysis, sartrocheliol A (1) was identified as an uncommon capnosane diterpene, while B–E (3, were established cembrane diterpenes. They displayed diverse structural features not only at distinctly different carbon frameworks but...

Investigation of the South China Sea nudibranch Hexabranchus sanguineus from Sanya Bay afforded, in addition to three known compounds, nine new diterpenoids 5,19-cycloclerodane- (sanyanolides A-D), clerodane- (sanyanolide E) and subersin- F-I) type. Remarkably, six aforementioned H. were also isolated sponge Chelonaplysilla sp. same water region, suggesting a trophic relationship between The structure absolute configuration compounds established by combination spectroscopic data, X-ray...

Two novel diterpenoids, sinuaustones A (1) and B (2), featuring an unprecedented tricyclo[9.3.1.0 3,15 ]tetradecane carbon framework were isolated from the South China Sea soft coral Sinularia australiensis .

Abstract Two new, 1 and 2 , along with one known isoindolone, 3 were isolated from the AcOEt extract of Lasiosphaera fenzlii Reich . The structures these compounds determined as 4,6‐dihydroxy‐1 H ‐isoindole‐1,3(2 )‐dione ( ), 4,6‐dihydroxy‐2,3‐dihydro‐1 ‐isoindol‐1‐one clitocybin A ) on basis chemical spectroscopic evidences. bioactivity assays revealed that all them devoid significant cytotoxicities against tumor cells, whereas exhibited potent antiangiogenic activity by inhibiting...

A detailed chemical investigation of the Sanya Bay nudibranch Hexabranchus sanguineus yielded thirteen new sesquiterpenoids, namely sanyagunins A-H, sanyalides A-C, and sanyalactams B, along with eleven known related ones. Sanyalactams B feature an unprecedented hexahydrospiro[indene-2,3'-pyrrolidine] core. The structures compounds were established by a combination extensive spectroscopic data analysis, quantum mechanical-nuclear magnetic resonance methods, modified Mosher's method, X-ray...

The chemical investigation of the rarely studied soft coral Sinularia tumulosa resulted in discovery five oxygenated cembrane diterpenes 1-5, including two new compounds situmulins A (1) and B (2). structures 1 2 were established through extensive analyses 1D 2D NMR spectral data together with comparisons known compounds. Furthermore, absolute configuration was determined by time-dependent density functional theory (TDDFT) ECD approach, while relative assigned via quantum mechanical-NMR...

The balance between bone-resorbing osteoclasts and bone-forming osteoblasts is essential for the process of bone remodeling. Excessive osteoclast differentiation plays a pivotal role in pathogenesis diseases such as rheumatoid arthritis osteoporosis. In present study, we examined whether 7,8-epoxy-11-sinulariolide acetate (Esa), marine natural product soft coral Sinularia siaesensis, attenuates inflammation osteoclastogenesis vitro. results indicated that Esa significantly inhibited...

Applying the emerging molecular networking strategy, an uncommon cembranoid orthoester, sarcotortin A (1), featuring a 3/14/8/5-fused scaffold, unusual eunicellane-type diterpenoid, sarcotorolide (2), and two new biscembranoids, ximaolides M N (7 8), along with nine known terpenoids 3-6 9-13 were isolated from Hainan soft coral Sarcophyton tortuosum. The structure absolute configuration of all compounds established by combination spectroscopic data, X-ray diffraction analysis, and/or quantum...

Two new cembranoids, namely sarcoboettgerols D and E, together with four known related ones, have been isolated from the soft coral Sarcophyton boettgeri collected Weizhou Island in South China Sea. Their structures including absolute configurations were elucidated by extensive spectroscopic analysis, quantum mechanical nuclear magnetic resonance methods, time-dependent density functional theory-electronic circular dichroism calculations, as well comparison reported data literature. A...

Fifteen new diterpenoids, namely xishaklyanes A-O (1-15), along with three known related ones (16-18), were isolated from the soft coral Klyxum molle collected Xisha Islands, South China Sea. The stereochemistry of compounds was elucidated by a combination detailed spectroscopic analyses, chemical derivatization, quantum calculations, and comparison reported data. absolute configuration compound 18 established modified Mosher's method for first time. In bioassay, some these exhibited...

Marine invertebrates serve as rich sources of secondary metabolites with intriguing chemical diversities and a wide spectrum biological activities. Particularly, marine shell-less sacoglossan mollusks have attracted much attentions due to the fact that apply complex defense agents against their predators. With purpose discovering bioactive develop marine-derived medicines from South China Sea, we conducted study on photosynthetic mollusk Placobranchus ocellatus. As result, seven new γ-pyrone...

Chemical investigation of the Chinese soft coral Lobophytum sp. has resulted in isolation six new compounds, namely lobosteroids A–F (1–6), along with four known compounds. Their structures were determined by extensive spectroscopic analysis and comparison spectral data reported literature. Among them, absolute configuration 1 was X-ray diffraction analysis. These steroids characterized either presence an α,β-αꞌ,βꞌ-unsaturated...

To explore the steroidal constituents of soft coral Lobophytum sp. at coast Xuwen County, Guangdong Province, China, a chemical investigation above-mentioned was carried out. After repeated column chromatography over silica gel, Sephadex LH-20, and reversed-phase HPLC, six new steroids, namely lobosteroids A-F (1-6), along with four known compounds 7-10, were obtained. Their structures determined by extensive spectroscopic analysis comparison spectral data reported in literature. Among them,...

The detailed chemical investigations of the South China Sea soft corals Sinularia tumulosa and depressa, yielded two new compounds, namely tumulosterol A (1) 11'-hydroxy-α-tocopherylquinone (3), along with four related known ones (2, 5–7). Their structures were determined by extensive spectroscopic analysis comparison spectral data previously reported in literature. In bioassays, compound 1 displayed significant cytotoxic effects against H1975 MDA-MB-231 cells IC50 values 6.0 6.3 µM,...

Fifteen new diterpenoids, namely xishaklyanes A-O (1-15), along with three known related ones (16-18), were isolated from the soft coral Klyxum molle collected Xisha Islands, South China Sea. The stereochemistry of compounds elucidated by a combination detailed spectroscopic analyses, chemical syntheses, quantum calculations and comparison reported data. absolute configuration compound 18 was established modified Mosher's method for first time. In bioassay, some these exhibited...

Two new scalarane sesterterpenes, hyrtiosins F and G (1 2), along with two known related compounds, hyrtiosin D sesterstatin 6 (3 4), were isolated from the Hainan marine sponge Hyrtios erecta. The structures of compounds 1 2 determined by detailed analysis 1D 2D NMR spectra comparison spectroscopic data those reported in literatures.