A5100343815- Endoplasmic Reticulum Stress and Disease
- Colorectal Cancer Treatments and Studies
- Cancer Treatment and Pharmacology
- Prostate Cancer Treatment and Research
- Estrogen and related hormone effects
- Cancer, Hypoxia, and Metabolism
- Tissue Engineering and Regenerative Medicine
- Cancer Research and Treatments
- Autophagy in Disease and Therapy
- Mitochondrial Function and Pathology
- Advanced Breast Cancer Therapies
- Heat shock proteins research
- COVID-19 diagnosis using AI
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- Neonatal Respiratory Health Research
- Hepatitis C virus research
- Peptidase Inhibition and Analysis
- Monoclonal and Polyclonal Antibodies Research
- Genetic factors in colorectal cancer
- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Pharmacological Effects of Natural Compounds
Oslo University Hospital
2010-2025
Guiyang Medical University
2022-2025
University of Oslo
2014-2024
Boston University
2023-2024
Affiliated Hospital of Southwest Medical University
2022-2024
Nanjing University of Chinese Medicine
2022-2024
First Affiliated Hospital of Zhengzhou University
2022-2024
University of Pittsburgh
2022-2024
University of Pittsburgh Medical Center
2024
First Affiliated Hospital of Xi'an Jiaotong University
2022-2023
Abstract Activation of endoplasmic reticulum (ER) stress/the unfolded protein response (UPR) has been linked to cancer, but the molecular mechanisms are poorly understood and there is a paucity reagents translate this for cancer therapy. Here, we report that an IRE1α RNase-specific inhibitor, MKC8866, strongly inhibits prostate (PCa) tumor growth as monotherapy in multiple preclinical models mice shows synergistic antitumor effects with current PCa drugs. Interestingly, global transcriptomic...
Abstract Background Although lung cancer is among the few malignancies for which we know primary etiological agent (i.e., cigarette smoke), a precise understanding of temporal sequence events that drive tumor progression remains elusive. In addition to finding smoke (CS) impacts functioning key pathways with significant roles in redox homeostasis, xenobiotic detoxification, cell cycle control, and endoplasmic reticulum (ER) functioning, our data highlighted defensive role unfolded protein...
Research Article11 April 2015Open Access Source Data Divergent androgen regulation of unfolded protein response pathways drives prostate cancer Xia Sheng Department Biosciences, University Oslo, Norway Search for more papers by this author Yke Jildouw Arnoldussen Margrethe Storm Martina Tesikova Hatice Zeynep Nenseth Sen Zhao Ladan Fazli The Vancouver Prostate Centre, Vancouver, BC, Canada Paul Rennie Bjørn Risberg Institute Cancer Genetics and Informatics, Oslo Hospital, Division Pathology,...
Wuji Wan (WJW) is a traditional Chinese medicine formula that can be found in the "Prescriptions of Taiping Benevolent Dispensary" has been employed treating gastric discomfort, burning epigastric pain, and reflux for hundreds years shown promise ulcers (GUs). However, active components mechanism action against GUs remain unclear. The aim this study was to explore WJW elucidate underlying involved GUs. Initially, cell viability measured by counting kit 8 (CCK-8) assay evaluate efficacy...
Intratumoral TLR9 agonists and anti-PD-1 produce clinical responses broad immune activation. We conducted a single-arm study of neoadjuvant agonist vidutolimod combined with nivolumab in high-risk resectable melanoma. In 31 evaluable patients, 55% major pathologic response (MPR) was observed, meeting primary endpoint. MPR associated necrosis, melanophagocytosis increased CD8
Abstract Janus Kinases (JAKs) play a crucial role as therapeutic targets for various cancers. However, the current JAK inhibitors (JAKi) available have limited benefits due to their lack of selectivity. This review focuses on structural analysis elucidate molecular determinants JAKs specificity and discovery design selective JAKi. It includes descriptions comparison different structures binding sites, comparative JAKi modes, detailed interaction fingerprints (IFPs), an extensive...
Unfolded protein response (UPR) is a central stress pathway that hijacked by tumor cells for their survival. Here, we find IRE1α signaling, one of the canonical UPR arms, increased in prostate cancer (PCa) patient tumors. Genetic or small molecule inhibition syngeneic mouse PCa models and an orthotopic model decreases growth. ablation potentiates interferon responses activates immune system related pathways microenvironment (TME). Single-cell RNA-sequencing analysis reveals targeting reduces...
The androgen receptor (AR) and the phosphoinositide 3-kinase (PI3K)/protein kinase B/mammalian target of rapamycin (mTOR) signaling are two major proliferative pathways in a number tissues main therapeutic targets various disorders, including prostate cancer (PCa). Previous work has shown that there is reciprocal feedback regulation PI3K AR PCa, suggesting cotargeting both may enhance efficacy. Here we show proteins encoded by androgen-regulated genes, kallikrein related peptidase 4 (KLK4)...
Abstract Background The ERBB2 oncogene hypothesis is challenged in hepatocellular carcinoma (HCC) with the conflicting evidences of human epidermal growth factor receptor 2 (HER2) overexpression. HER2 could be a new target as treatment option for HCC well tumor recurrence after surgery. biology needs further explorations. Methods Clinical and mRNA data patients were obtained from TCGA cohort, GSE89377 GSE115018. Western Blotting immunohistochemistry employed to test expression HER2,...
Objective: Tofacitinib (TOF) is a Janus kinase (JAK) inhibitor used in the treatment of rheumatoid arthritis (RA), but mechanism its action remains unclear. In this study, we investigated influence TOF on gamma delta regulatory T-cell (γδTreg)/γδT17 cell balance RA and role nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) inflammasome process. Methods: We detected levels inflammatory factors serum patients before after administration using an enzyme-linked immunosorbent assay...
Targeting the G2/M checkpoint mediator WEE1 has been explored as a novel treatment strategy in ovarian cancer, but mechanisms underlying its efficacy and resistance remains to be understood. Here, it is demonstrated that inhibitor AZD1775 induces endoplasmic reticulum stress activates protein kinase RNA-like ER (PERK) inositol-required enzyme 1α (IRE1α) branches of unfolded response (UPR) TP53 mutant (mtTP53) cancer models. This facilitated through NF-κB mediated senescence-associated...
Nutritionally relevant levels of genistein, the predominant isoflavone in soyabean associated with lower risk prostate cancer (PCa), may modulate expression tissue biomarkers prediction and progression. A phase 2 placebo-controlled, randomised, double-blind clinical trial was conducted forty-seven Norwegian patients before prostatectomy. Intervention 30 mg genistein or placebo capsules daily for 3-6 weeks. Luminal cells from malignant benign glands were isolated laser capture microdissection...