A5101440712- Asphalt Pavement Performance Evaluation
- Smart Materials for Construction
- Infrastructure Maintenance and Monitoring
- Protein Degradation and Inhibitors
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Cervical Cancer and HPV Research
- Immune cells in cancer
- Alzheimer's disease research and treatments
- Hepatitis Viruses Studies and Epidemiology
- Endoplasmic Reticulum Stress and Disease
- Advanced Breast Cancer Therapies
- Hepatitis C virus research
- Advanced Photocatalysis Techniques
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Ovarian function and disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Stress Responses and Cortisol
- S100 Proteins and Annexins
- Multiple Myeloma Research and Treatments
- interferon and immune responses
- Gestational Diabetes Research and Management
- Plant Gene Expression Analysis
- DNA Repair Mechanisms
University of Science and Technology of China
2024-2025
Huazhong University of Science and Technology
2016-2024
Tongji Hospital
2016-2024
Hubei Engineering University
2023-2024
Changsha University of Science and Technology
2015-2024
Huazhong Agricultural University
2021
Sun Yat-sen University
2018
The First Affiliated Hospital, Sun Yat-sen University
2018
Cervical cancer (CC) that is caused by high-risk human papillomavirus (HPV) remains a significant public health problem worldwide. HPV integration sites can be silent or actively transcribed, leading to the production of viral-host fusion transcripts. Herein, we demonstrate only productive were nonrandomly distributed across both viral and host genomes, suggesting are under selection likely contribute CC pathophysiology. Furthermore, using large-scale, multi-omics (clinical, genomic,...
Abstract Hepatitis E virus (HEV) genotype 1 infection is common and can emerge as outbreaks in developing areas, thus posing a threat to public health. However, due the absence of feasible animal models, mechanism HE pathogenesis remains obscure. The HEV pathogenic has been suggested be mediated by immune system not direct viral duplication. We firstly discovered that open reading frame 3 (ORF3) protein downregulates TLR3-mediated NF-κB signaling Human A549 Lung Epithelial Cells (A549 cells)...
Abstract Generalization is a fundamental cognitive ability of organisms to deal with the uncertainty in real-world situations. Excessive fear generalization and impaired reward are closely related many psychiatric disorders. However, neural circuit mechanism for its role anxiety-like behaviours remain elusive. Here, we found robust activation calbindin 1-neurons (Calb 1) posterior basolateral amygdala (pBLA), simultaneous an ambiguous cue after conditioning mice. We identify infralimbic...
Targeting the G2/M checkpoint mediator WEE1 has been explored as a novel treatment strategy in ovarian cancer, but mechanisms underlying its efficacy and resistance remains to be understood. Here, it is demonstrated that inhibitor AZD1775 induces endoplasmic reticulum stress activates protein kinase RNA-like ER (PERK) inositol-required enzyme 1α (IRE1α) branches of unfolded response (UPR) TP53 mutant (mtTP53) cancer models. This facilitated through NF-κB mediated senescence-associated...
Abstract Introduction Previous studies have demonstrated that abnormal body mass index (BMI) is associated with adverse pregnancy outcomes in frozen–thawed embryo transfer cycles. However, the relationship between BMI and perinatal patients polycystic ovary syndrome (PCOS) remains unclear. Furthermore, whether a diagnosis of PCOS could result women different BMIs unknown. Material methods A historical cohort study included 1667 12 256 without after freeze‐all policy January 2016 December...
Background: Ovarian cancer (OC) is the deadliest malignant tumor in female reproductive system. Sphingolipid metabolism (SM) crucial for cellular function and has been linked to OC progression. Dysregulation of sphingolipid pathways contributes growth, chemoresistance, metastasis OC. Currently, investigations into relationship between sphingolipid-related genes (SRGs) prognosis their initial stages. Our study aimed develop a novel molecular subtyping based on SRGs construct signature predict...
Abstract WEE1 plays an important role in the regulation of cell cycle G2/M checkpoints and DNA damage response (DDR). Inhibition can increase instability genome have anti–tumor effects some solid tumors. However, it has certain limitations for multiple cancer cells from different lineages. Therefore, we consider use synthetic lethal interactions to enhance therapeutic effect. Our experiments proved that inhibitor (WEE1i) activate ataxia telangiectasia RAD3‐related (ATR) pathway blockage ATR...
Background Ovarian cancer (OC) is one of the most lethal gynecologic cancers. Growing evidence has proven that CDK4/6 plays a key role in tumor immunity and prognosis many However, expression function OC remain unclear. Therefore, we aimed to explore influence OC, especially on immunity. Methods We analyzed using The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) Genotype Tissue (GTEx) data. Subsequently, used cytoHubba plug-in Cytoscape software starBase identify noncoding RNAs...
Background Mismatch repair deficiency (dMMR) is a well-recognized biomarker for response to immune checkpoint blockade (ICB). Strategies convert MMR-proficient (pMMR) dMMR phenotype with the goal of sensitizing tumors ICB are highly sought. The combination bromodomain containing 4 (BRD4) inhibition and provides promising antitumor effect. However, mechanisms underlying remain unknown. Here, we identify that BRD4 induces persistent in cancers. Methods We confirmed correlation between mismatch...
Rhodamine B (RhB) in dyes is widely used various industries, but it poses a great threat to the natural environment and human health. In this work, series of thermosensitive polymer materials, PNxDy, with controllable morphology particle size were prepared by free radical polymerization using N-isopropylacrylamide N,N-dimethylacrylamide as monomers. Then, PNxDy template, bimetallic Mn- Co-doped MCM-41 molecular sieves good properties microwave-assisted hydrothermal method. The effects...
Fog seal technology has the advantages of convenient construction and rapid opening traffic, it a broad application prospect in maintenance airport asphalt pavement. However, current evaluation indices fog materials are not relevant enough to reflect their performance strengths weaknesses comprehensively systematically. Moreover, there is lack research on non-emulsification class materials. This aims compare contrast various types for pavement provide suggestions optimizing achieve better...
Previous studies have discussed the pregnancy outcomes of diminished ovarian reserve (DOR) patients. However, data on embryonic development potential, neonatal outcomes, and maternal complications DOR patients still remained unknown. This is first study to investigate risk perinatal among women < 38 years.Retrospective cohort was conducted. Patients (< years age) undergoing their oocyte retrieval cycle were included. divided into group non-DOR group. Pregnancy fresh cumulative live birth...
In this work, a series of thermosensitive ionic liquid functionalized polymers, PN
Introduction: Type 2 diabetes mellitus (T2DM) is an independent risk factor of Alzheimer's disease (AD), and populations with mild cognitive impairment (MCI) have high incidence to suffer from AD. Therefore, discerning who may be more vulnerable MCI, among the increasing T2DM populations, important for early intervention eventually decreasing prevalence rate This study was explore whether change plasma β-amyloid (Aβ) could a biomarker distinguish MCI (T2DM-MCI) non-MCI (T2DM-nMCI) in...
To assess the effects of hepatitis E virus (HEV) on production type I interferons (IFNs) and determine underlying mechanisms.We measured interferon (IFN)-alpha -beta (-α/β) in genotype 3 HEV-infected C3A cells at different time points (0, 8, 12, 24, 48, 72 120 h) by enzyme-linked immunosorbent assay (ELISA). The expression levels IFN-stimulated gene (ISG)15 were tested western blotting. plasmid-expressing open reading frame (ORF3) or control plasmids (green fluorescent protein-expressing)...
Fog seal technology is widely used in airport asphalt pavement. The research on the performance and application of fog material basically at level modified emulsified asphalt. test method existing specification has defects. Three kinds materials with different substrates were selected this paper. Based characteristics treatment relevant specifications Wet Track Abrasion Test (WTAT), Cantabro test, Water seepage Pendulum instrument tester pavement friction coefficient improved. types seals....
Deicing agents are widely used to remove ice and snow on airport pavement, ensuring air traffic operation safety. However, excessive spraying may affect the performance of pavement. The effects different chloride deicing asphalt mixture have been assessed by previous studies. three (NaCl, KHF-1A, NW056) were selected. Conducting various tests examine their influence mixture. include DSR test, BBR indirect tensile bending test small beam, freeze-thaw splitting test. results indicate that...
<title>Abstract</title> <bold>Purpose: </bold>Ovarian cancer (OC) is an invasive gynecological with overall 5-year survival rate less than 45%. Endoplasmic reticulum (ER) stress influence oncogenic events and immune-regulatory programmers to dictate malignant progression, antitumor immunity response treatment. However, endoplasmic reticulumstress (ERS) in ovarian not fully understood needs further study. <bold>Methods: </bold>The RNA-sequencing clinical data were obtained from The Cancer...
The periodic changes in climatic factors cause the pavement temperature field to change significantly, resulting fatigue damage caused by stress, and influence depth has a critical value. To reveal range variation pattern of rubber-modified under frequent rainfall high temperatures, based on indoor tests finite element model, evolution law different influencing fields was determined single factor sensitivity analysis method. degree each analyzed using Pearson correlation. results showed that...