A5048686357- Alzheimer's disease research and treatments
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Cholinesterase and Neurodegenerative Diseases
- Nuclear Receptors and Signaling
- S100 Proteins and Annexins
- 14-3-3 protein interactions
- Stress Responses and Cortisol
- Neurological Disease Mechanisms and Treatments
- Ubiquitin and proteasome pathways
- Neuroendocrine regulation and behavior
- Protein Degradation and Inhibitors
- Grit, Self-Efficacy, and Motivation
- Education and Learning Interventions
- Olfactory and Sensory Function Studies
- Neurotransmitter Receptor Influence on Behavior
- Photoreceptor and optogenetics research
- Advanced Chemical Sensor Technologies
- Receptor Mechanisms and Signaling
- Advanced Glycation End Products research
- Advanced biosensing and bioanalysis techniques
- Computational Drug Discovery Methods
- Machine Learning in Bioinformatics
- Psychological and Educational Research Studies
- Chemical Synthesis and Analysis
Huazhong University of Science and Technology
2020-2025
Wuhan University
2025
Renmin Hospital of Wuhan University
2025
Abstract The basolateral amygdala (BLA) and ventral hippocampal CA1 (vCA1) are cellularly functionally diverse along their anterior–posterior superficial-deep axes. Here, we find that anterior BLA (aBLA) posterior (pBLA) innervate deep-layer calbindin1-negative (Calb1−) superficial-layer calbindin1-positive neurons (Calb1+) in vCA1, respectively. Photostimulation of pBLA–vCA1 inputs has an anxiolytic effect mice, promoting approach behaviours during conflict exploratory tasks. By contrast,...
Abnormal hyperphosphorylation and accumulation of tau protein play a pivotal role in neurodegeneration Alzheimer's disease (AD) many other tauopathies. Selective elimination hyperphosphorylated is promising for the therapy these diseases. We have conceptualized strategy, named dephosphorylation-targeting chimeras (DEPTACs), specifically hijacking phosphatases to debilitate its hyperphosphorylation. Here, we conducted step-by-step optimization each constituent motif generate DEPTACs with...
Abstract Generalization is a fundamental cognitive ability of organisms to deal with the uncertainty in real-world situations. Excessive fear generalization and impaired reward are closely related many psychiatric disorders. However, neural circuit mechanism for its role anxiety-like behaviours remain elusive. Here, we found robust activation calbindin 1-neurons (Calb 1) posterior basolateral amygdala (pBLA), simultaneous an ambiguous cue after conditioning mice. We identify infralimbic...
Intraneuronal accumulation of hyperphosphorylated tau is a hallmark Alzheimer's disease (AD). Given the significant correlation between pathology and memory loss in AD patients, identifying vulnerable brain regions, particularly susceptible neuron types these will advance our understanding onset shed light on therapeutic strategies to manage its progression. Immunofluorescent staining was employed identify regions AD. A combination chemogenetics, electrophysiological recording, vivo Ca2+...
Abstract Background Episodic memory loss is a prominent clinical manifestation of Alzheimer’s disease (AD), which closely related to tau pathology and hippocampal impairment. Due the heterogeneity brain neurons, specific roles different neurons in terms their sensitivity accumulation contribution AD-like social remain unclear. Therefore, further investigation necessary. Methods We investigated effects by Tandem mass tag proteomic phosphoproteomic analysis, behavioural tests,...
Intraneuronal accumulation of hyperphosphorylated tau is a defining hallmark Alzheimer's disease (AD). However, mouse models imitating AD-exclusive neuronal pathologies are lacking.
Abstract Background Abnormal tau accumulation and cholinergic degeneration are hallmark pathologies in the brains of patients with Alzheimer’s disease (AD). However, sensitivity neurons to AD-like strategies ameliorate tau-disrupted spatial memory terms neural circuits still remain elusive. Methods To investigate effect mechanism circuit Alzheimer's disease-related hippocampal memory, overexpression human wild-type Tau (hTau) medial septum (MS)-hippocampus (HP) was achieved by specifically...
After aversive stress, people either choose to return their previously familiar social environment or tend adopt temporary withdrawal buffer negative emotions. However, which behavior intervention is more appropriate and when remain elusive. Here, we unexpectedly found that stressed mice experiencing isolation exhibited less anxiety than those contact. Within the first 24 h after returning previous environment, experienced acute restraint stress (ARS) displayed low interest but...
Intracellular deposition of hyperphosphorylated tau has been reported in the brain epilepsy patients, but its contribution to epileptic seizures and association with spatial cognitive functions remain unclear. Here, we found that repeated optogenetic stimulation excitatory neurons ventral hippocampal CA1 subset could induce a controllable seizure mice. Simultaneously, mice showed learning memory deficits prominently elevated total phospho-tau levels brain. Importantly, selective facilitating...
Introduction: Type 2 diabetes mellitus (T2DM) is an independent risk factor of Alzheimer's disease (AD), and populations with mild cognitive impairment (MCI) have high incidence to suffer from AD. Therefore, discerning who may be more vulnerable MCI, among the increasing T2DM populations, important for early intervention eventually decreasing prevalence rate This study was explore whether change plasma β-amyloid (Aβ) could a biomarker distinguish MCI (T2DM-MCI) non-MCI (T2DM-nMCI) in...
Olfactory dysfunction appears prior to cognitive decline, and thus it has been suggested be an early predictor of Alzheimer's disease. However, is currently not known whether how olfactory threshold test could serve as a quick screening tool for impairment.To define impairment in two independent cohorts.The participants are comprised cohorts China, 1,139 inpatients with type 2 diabetes mellitus (T2DM, Discovery cohort) 1,236 community-dwelling elderly (Validation cohort). functions were...
The purpose of the present study is to analyze development Flash and Edutainment in field Educational Technology.This critically reviewed analyzed articles about Edutainment, from 1999 2010 (end October), five journals it.103 identified synthesis comparisons were grouped into three latitudes representing commonalities: number distribution studies, content research, center research.Some problems found though analysis some suggestions have been proposed.
Background: Both glycogen synthase kinase-3β (GSK-3β) activation and ApoE ε4 genotype contribute to the cognitive decline in patients with type 2 diabetes mellitus (T2DM), which shows a high incidence of developing into Alzheimer’s disease (AD). However, relationship between GSK-3β impairment T2DM remains unclear.Methods: genotypes platelet were measured 1139 recruited from five medical centers. Cognitive functions assessed by Mini-Mental State Examination (MMSE). The association...