A5101804073- Alzheimer's disease research and treatments
- Geochemistry and Geologic Mapping
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Digital Marketing and Social Media
- Memory and Neural Mechanisms
- Tryptophan and brain disorders
- Cholinesterase and Neurodegenerative Diseases
- Rheumatoid Arthritis Research and Therapies
- Epigenetics and DNA Methylation
- Systemic Lupus Erythematosus Research
- Digital Games and Media
- Geoscience and Mining Technology
- Ubiquitin and proteasome pathways
- Skin Protection and Aging
- Coronary Interventions and Diagnostics
- Sexuality, Behavior, and Technology
- Histone Deacetylase Inhibitors Research
- Biochemical Analysis and Sensing Techniques
- Stress Responses and Cortisol
- Customer Service Quality and Loyalty
- Dementia and Cognitive Impairment Research
- Cardiac Imaging and Diagnostics
- S100 Proteins and Annexins
- Monoclonal and Polyclonal Antibodies Research
Huazhong University of Science and Technology
2016-2025
Mudanjiang Medical University
2023-2024
Shunyi Hospital of Beijing Traditional Chinese Medicine Hospital
2014-2024
First People's Hospital of Chongqing
2020-2024
Capital Medical University
2024
Wuhan University
2012-2024
Fujian Medical University
2011-2023
Union Hospital
2012-2023
Fujian Institute of Microbiology
2021-2023
Xichang University
2020-2023
Intracellular accumulation of tau is a hallmark pathology in Alzheimer disease (AD) and the related tauopathies, thus targeting could be promising for drug development. Proteolysis Targeting Chimera (PROTAC) novel discovery strategy selective protein degradation from within cells.
Abstract The basolateral amygdala (BLA) and ventral hippocampal CA1 (vCA1) are cellularly functionally diverse along their anterior–posterior superficial-deep axes. Here, we find that anterior BLA (aBLA) posterior (pBLA) innervate deep-layer calbindin1-negative (Calb1−) superficial-layer calbindin1-positive neurons (Calb1+) in vCA1, respectively. Photostimulation of pBLA–vCA1 inputs has an anxiolytic effect mice, promoting approach behaviours during conflict exploratory tasks. By contrast,...
Abstract Different emotional states lead to distinct behavioural consequences even when faced with the same challenging events. Emotions affect learning and memory capacities, but underlying neurobiological mechanisms remain elusive. Here we establish models of learned helplessness (LHL) hopefulness (LHF) by exposing animals inescapable foot shocks or anticipated avoidance trainings. The LHF show spatial potentiation excitatory monosynaptic upscaling between posterior basolateral amygdale...
Abstract Diets high in sugar are recognized as a serious health problem, and there is drive to reduce their consumption. Steviol glycosides natural zero-calorie sweeteners, but the most desirable ones biosynthesized with low yields. UGT76G1 catalyzes β (1–3) addition of glucose steviol glycosides, which gives them preferred taste. able transfer multiple substrates yet remains highly specific glycosidic linkage it creates. Here, we report complex structures enzyme combined biochemical data,...
Glycogen synthase kinase-3β (GSK-3β) is one of the most effective kinases in promoting tau hyperphosphorylation and accumulation Alzheimer's disease (AD). However, it not clear how GSK-3β activity regulated during AD progression.We firstly used mass spectrometry to identify acetylation site GSK-3β, then established cell animal models acetylation. Next, we conducted molecular, biological behavioral tests. Finally, designed a peptide test whether blocking tau-mediated could be beneficial AD.We...
Alzheimer's disease (AD) is multifactorial with unclear etiopathology. Due to the complexity of AD, many attempted single therapy treatments, like Aβ immunization, have generally failed. Therefore, there a need for drugs multiple benefits. Naturally occurring phytochemicals neuroprotective, anti-amyloidogenic, antioxidative, and anti-inflammatory properties could be possible way out. In this study, effect Moringa oleifera (MO), naturally plant high anti-inflammatory, neuroprotective effects,...
Zinc ions highly concentrate in hippocampus and play a key role modulating spatial learning memory. At time when dietary fortification supplementation of zinc have increased the consuming level especially youth, toxicity overdose on brain function was underestimated. In present study, weaning ICR mice were given water supplemented with 15 ppm Zn (low dose), 60 (high dose) or normal lab for 3 months, behavior homeostasis tested. Mice fed high dose showed hippocampus-dependent memory...
Steviol glycosides are the intensely sweet components of extracts from Stevia rebaudiana. These molecules comprise an invariant steviol aglycone decorated with variable glycans and could widely serve as a low-calorie sweetener. However, most desirable Reb D M, devoid unpleasant aftertaste, naturally produced only in trace amounts due to low levels specific β (1-2) glucosylation Stevia. Here, we report biochemical structural characterization OsUGT91C1, glycosyltransferase Oryza sativa, which...
Although numerous studies have indicated that chronic stress causes cognitive dysfunction with the impairment of synaptic structures and functions, relationship between deficits induced by repeated restraint level NMDA receptors in subregion hippocampus has been relatively unknown until now. In this study, 3-week-old male Sprague-Dawley rats were exposed to for seven consecutive days, their functions evaluated through behavioral tests, then they sacrificed electrophysiological,...
Codonopsis pilosula Polysaccharides (CPPs), a traditional Chinese medicine used for thousands of years, is potential neuroprotective polysaccharide via relatively poorly understood mechanism. We previously reported that CPPs attenuated tau pathology in hTau transfected mice and therefore the current work investigated effect on Aβ toxicity cognitive defects APP/PS1 model. It was found one-month intragastric administration significantly ameliorated mice. In addition, treatment mitigated loss...
Abstract Generalization is a fundamental cognitive ability of organisms to deal with the uncertainty in real-world situations. Excessive fear generalization and impaired reward are closely related many psychiatric disorders. However, neural circuit mechanism for its role anxiety-like behaviours remain elusive. Here, we found robust activation calbindin 1-neurons (Calb 1) posterior basolateral amygdala (pBLA), simultaneous an ambiguous cue after conditioning mice. We identify infralimbic...
CD4CD25 regulatory T cells (Tregs) play a key role in the prevention of various inflammatory and autoimmune disorders by suppressing immune responses. The beneficial effect statins on myocardial ischemia-reperfusion injury (IRI) depends part their immunomodulatory anti-inflammatory mechanisms. We aimed to determine whether Tregs contribute statin-induced cardioprotection against IRI.Thirty-two rats were divided into four groups: sham, (IR), rosuvastatin (RSV)/IR, mevalonic acid (MVA)+RSV/IR....
BackgroundBoth type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) are common age-associated disorders T2DM patients show an increased risk to suffer from AD, however, there is currently no marker identify who in populations will develop AD. Since glycogen synthase kinase-3β (GSK-3β) activity, ApoE genotypes olfactory function involved both AD pathogenesis, we investigate whether alterations of these factors can cognitive impairment patients.MethodsThe ability was evaluated using...
Codonopsis pilosula polysaccharide (CPPs), a natural products with potentially lower toxicity and better bioavailability has been used in traditional Chinese medicine for 1000s of years neuroprotective mitigates tau pathology Alzheimer's disease (AD) mouse model. However, whether CPPs can relieve AD cognitive defects remains poorly understood. Here we reported that remarkably increased the cell viability PP2A activity, decreased phosphorylation HEK 293/tau cells. Next, employed an...
The impairment of histone acetylation is causally linked to the cognitive decline in Alzheimer's disease (AD). In addition acetyltransferases (HATs) and deacetylases (HDACs), inhibitor (INHAT) can also regulate acetylation. As a key component INHAT, level ANP32A selectively upregulated brain AD patients. Here we investigated whether downregulating rescue AD-like synapse memory deficits.RFP-labeled lentiviral ANP32A-shRNA was infused stereotaxically into hippocampal CA3 region human tau...
Casein kinase 2 (CK2) is highly activated in Alzheimer disease (AD) and associated with neurofibrillary tangles formation. Phosphorylated SET, a potent PP2A inhibitor, mediates tau hyperphosphorylation AD. However, whether CK2 phosphorylates SET regulates pathological phosphorylation AD remains unclear. Here we show that phosphorylating at Ser9 induced We found either Aβ treatment or overexpression stimulated activation leading to neurons animal models, while inhibition of by TBB abolished...
Significance BACE1 is a rate-limiting enzyme for amyloid beta polypeptide production, which plays crucial role in Alzheimer’s disease (AD) pathogenesis. However, how this essential protease posttranslationally regulated remains incompletely understood. In the current study, we show that K501 residue on BACE1, ubiquitin modification site, also competitively SUMOylated. We discovered SUMOylation of augments its stability and enzymatic activity, resulting senile plaque formation cognitive...
Abstract Background Episodic memory loss is a prominent clinical manifestation of Alzheimer’s disease (AD), which closely related to tau pathology and hippocampal impairment. Due the heterogeneity brain neurons, specific roles different neurons in terms their sensitivity accumulation contribution AD-like social remain unclear. Therefore, further investigation necessary. Methods We investigated effects by Tandem mass tag proteomic phosphoproteomic analysis, behavioural tests,...
High thrombus burden (HTB) is an independent predictor of no flow or low reflow during a primary percutaneous coronary intervention. This study aimed to compare immediate versus delayed stenting in ST-elevation myocardial infarction (STEMI) patients with HTB.In this retrospective, nonrandomized study, total 103 consecutive STEMI HTB (thrombus score, TBS≥3) were assigned (IS group, n=50) (DS n=53), decision that was made at the discretion operators. The IS group received stent placement...