A5100441319- MicroRNA in disease regulation
- Atherosclerosis and Cardiovascular Diseases
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Inflammasome and immune disorders
- Cytokine Signaling Pathways and Interactions
- Asthma and respiratory diseases
- Traditional Chinese Medicine Analysis
- Adipose Tissue and Metabolism
- Bacteriophages and microbial interactions
- Nuclear Receptors and Signaling
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Bone and Dental Protein Studies
- Machine Learning in Healthcare
- RNA modifications and cancer
- Genomics and Chromatin Dynamics
- Catalytic Cross-Coupling Reactions
- Galectins and Cancer Biology
- Microbial Natural Products and Biosynthesis
- Cardiac Ischemia and Reperfusion
- Immune Response and Inflammation
- Cancer Research and Treatments
- FOXO transcription factor regulation
- NF-κB Signaling Pathways
George Washington University
2021-2025
Guangxi University
2024-2025
Huazhong University of Science and Technology
2019-2025
Washington DC VA Medical Center
2024-2025
Veterans Health Administration
2024
West Anhui University
2024
Nanjing Medical University
2022-2024
Wuxi People's Hospital
2022-2024
Union Hospital
2021-2024
Shanghai First Maternity and Infant Hospital
2024
It remains unknown whether newly identified anti-inflammatory/immunosuppressive cytokine interleukin-35 (IL-35) is different from other anti-inflammatory cytokines such as IL-10 and transforming growth factor (TGF)-β in terms of inhibition inflammation initiation suppression full-blown inflammation. Using experimental database mining statistical analysis methods we developed, examined the tissue expression profiles regulatory mechanisms IL-35 comparison to cytokines. Our results suggest that...
The role of receptors for endogenous metabolic danger signals-associated molecular patterns has been characterized recently as bridging innate immune sensory systems to initiation inflammation in bone marrow-derived cells, such macrophages. However, it remains unknown whether endothelial cells (ECs), the cell type with largest numbers and first vessel exposed circulating blood, can sense hyperlipidemia. This report determined caspase-1 plays a ECs sensing hyperlipidemia promoting EC...
Abstract Hyperglycemia-induced reactive oxygen species (ROS) generation contributes to development of diabetic cardiomyopathy (DCM). This study was designed determine the effect an antioxidant butin (BUT) on ischemia/reperfusion-induced myocardial injury in mice. Myocardial ischemia/reperfusion (MI/R) induced C57/BL6J diabetes Infarct size and cardiac function were detected. For vitro study, H9c2 cells used. To clarify mechanisms, proteases inhibitors or siRNA Proteins levels investigated by...
Obesity paradox (OP) describes a widely observed clinical finding of improved cardiovascular fitness and survival in some overweight or obese patients. The molecular mechanisms underlying OP remain enigmatic partly due to lack animal models mirroring Using apolipoprotein E knock-out (apoE−/−) mice on high fat (HF) diet as an atherosclerotic obesity model, we demonstrated 1) microRNA-155 (miRNA-155, miR-155) is significantly up-regulated the aortas apoE−/− mice, miR-155 deficiency inhibits...
Background: Inflammatory factors play a crucial role throughout the development and progression of atherosclerosis, which has been considered as chronic vascular inflammatory disease. Luteolin, natural flavonoid exists in many medicinal materials, anti-inflammatory, anti-fibrotic other pharmacological effects. Recently, protective effects luteolin on cardiovascular disease have reported. However, there is paucity studies anti-atherosclerosis. Therefore, anti-atherosclerosis potential remains...
Coronavirus disease 2019 (COVID-19) has infected over 124 million people worldwide. In addition to the development of therapeutics and vaccines, evaluation sequelae in recovered patients is also important. Recent studies have indicated that COVID-19 ability infect intestinal tissues trigger alterations gut microbiota. However, whether these changes microbiota persist into recovery stage remains largely unknown. Here, we recruited seven healthy Chinese men male with an average 3-months after...
A general approach for the α-arylation of heteroarenes with nitroarenes via denitrative coupling is reported first time. Various heteroarenes, including derivatives furan, benzofuran, pyrrole, indole, thiophene, and benzothiophene, can be arylated at α-position in moderate to good yields. Mechanistic studies demonstrate that reaction proceeds a CMD pathway, C–H bond activation as rate-determining step. Furthermore, scalability applicability synthesis drug molecule exemplify utility this protocol.
Background Papillary thyroid micro-carcinoma (PTMC) is defined as a tumor with larger diameter ≤1 cm which has an indolent course and satisfying prognosis. However, the incidence of lymph node metastasis PTMC cannot be ignored. The aim this study was to assess in patients, well evaluate risk factors for both central metastases (CLNM) lateral (LLNM). Methods Patients who underwent thyroidectomy from January 2017 October 2020, pathologically diagnosed were enrolled our their medical records...
Abstract Background Glioblastoma multiforme (GBM) is the most aggressive form of brain cancer, and chemoresistance poses a significant challenge to survival prognosis GBM. Although numerous regulatory mechanisms that contribute have been identified, many questions remain unanswered. This study aims identify mechanism temozolomide (TMZ) resistance in Methods Bioinformatics antibody-based protein detection were used examine expression E2F7 gliomas its correlation with prognosis. Additionally,...
The internet has created new markets and enabled alternative business models for criminal activity, such as human trafficking. Consequently, research is needed to understand the complexity, occurrence, impact of internet-enabled crime on victims society. Many scholars have called interdisciplinary approaches study develop interventions address a broad range cybercrimes, but this call challenging implement. Therefore, we provide confessional account our experience associated with developing...
Abstract Objective We sought to evaluate the left atrial (LA) strain parameters of maintenance hemodialysis (MHD) patients before and after dialysis by two dimensional speckle tracking imaging (2D‐STI), explore effect volume load change on LA function. Methods Seventy‐six with end stage renal disease (ESRD) (HD) were enrolled in study protocol. The median duration was 24.0 (7.5, 59.5) months. In addition, 30 healthy subjects selected as control group. Comprehensive echocardiography performed...
Abstract The opioid crisis has disproportionately affected U.S. veterans, leading the Veterans Health Administration to implement prescribing guidelines. who receive care from both VA and non-VA providers—known as dual-system users—have an increased risk of Opioid Use Disorder (OUD). interaction between use demographic clinical factors, however, not been previously explored. We conducted a retrospective study 856,299 patient instances Washington DC Baltimore Medical Centers (2012–2019),...
Objective: Invasive lobular carcinoma (ILC) of breast is a common pathological subtype cancer, ranks second in terms incidence rate following invasive ductal carcinoma. The aim this study to construct nomogram for predicting overall survival (OS) patients with ILC and identify risk factors that affect their prognosis. Methods: diagnosed between 2010 2015 were extracted from Surveillance, Epidemiology, End Results (SEER) database. They randomly split into training set 18365 samples model...
A straightforward and efficient method has been developed for the transformation of aromatic CAr−H bond into CAr−NH₂ via nickel‐mediated C−H activation, eliminating need additional protection deprotection steps. This strategy employs 8‐aminoquinoline as a directing group urea nitrogen source, non‐toxic, inexpensive, stable bulk chemical. The reaction exhibits high selectivity, exclusively yielding mono‐aminated primary amines. Furthermore, protocol is tolerant wide range substrates with...
Abstract Mitofusin 1 (MFN1) plays a crucial role in mitochondrial fusion and oocyte development. However, its function preimplantation embryonic development potential involvement epigenetic regulation remain poorly understood. In this study, it is shown that MFN1 interacts with PADI6, key component of the cytoplasmic lattice oocytes early embryos. deficiency mice results reduced PADI6 levels decreased expression translational machinery components, which suppress protein synthesis activity...