A5037625112- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Mechanical Circulatory Support Devices
- Blood transfusion and management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Venous Thromboembolism Diagnosis and Management
- Cardiac Arrest and Resuscitation
- Trauma and Emergency Care Studies
- Renal function and acid-base balance
- Blood Coagulation and Thrombosis Mechanisms
- Long-Term Effects of COVID-19
- Electrolyte and hormonal disorders
- Cardiac and Coronary Surgery Techniques
- Maternal and fetal healthcare
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Pain Management
- Platelet Disorders and Treatments
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cardiovascular Issues in Pregnancy
- Heart Failure Treatment and Management
George Washington University
2020-2024
Creative Commons
2022
Porter Adventist Hospital
2022
Crowell & Moring (United States)
2022
University of Maryland, Baltimore
2017-2021
La Jolla Pharmaceutical (United States)
2020
Barro Colorado Island
2018
Icahn School of Medicine at Mount Sinai
2011-2016
Brooklyn Hospital Center
2015-2016
Institute of Technology Assessment
2015
BACKGROUND: Coronavirus disease-2019 (COVID-19) is associated with hypercoagulability and increased thrombotic risk in critically ill patients. To our knowledge, no studies have evaluated whether aspirin use reduced of mechanical ventilation, intensive care unit (ICU) admission, in-hospital mortality. METHODS: A retrospective, observational cohort study adult patients admitted COVID-19 to multiple hospitals the United States between March 2020 July was performed. The primary outcome need for...
Prior observational studies suggest that aspirin use may be associated with reduced mortality in high-risk hospitalized patients COVID-19, but aspirin's efficacy moderate COVID-19 is not well studied.To assess whether early lower odds of in-hospital COVID-19.Observational cohort study 112 269 enrolled from January 1, 2020, through September 10, 2021, at 64 health systems the United States participating National Institute Health's COVID Cohort Collaborative (N3C).Aspirin within first day...
Abstract Background High dose vasopressors portend poor outcome in vasodilatory shock. We aimed to evaluate the impact of baseline vasopressor on outcomes patients treated with angiotensin II (AT II). Methods Exploratory post-hoc analysis Angiotensin for Treatment High-Output Shock (ATHOS-3) trial data. The ATHOS-3 randomized 321 shock, who remained hypotensive (mean arterial pressure 55–70 mmHg) despite receiving standard care support at a norepinephrine-equivalent (NED) > 0.2 µg/kg/min,...
Corticosteroids are part of the treatment guidelines for COVID-19 and have been shown to improve mortality. However, impact corticosteroids on development secondary infection in is unknown. We sought define rate critically ill patients with determine effect corticosteroid use mortality COVID-19.One hundred thirty-five admitted Intensive Care Unit (ICU) at University Maryland Medical Center were included this single-center retrospective analysis. Demographics, symptoms, culture data, directed...
Over 6 million esophagogastroduodenoscopy (EGD) procedures are performed in the United States each year. Patients having anesthesia for advanced EGD procedures, such as interventional at high risk hypoxemia.Our primary study aim was to evaluate whether high-flow nasal cannula (HFNC) oxygen reduces incidence of hypoxemia during EGD. Secondarily, we studied HFNC hypercarbia or hypotension. After obtaining written informed consent, adults EGD, expected last longer than 15 minutes, were randomly...
Critically ill patients with coronavirus disease 2019 (COVID-19) have been observed to be hypercoagulable, but the mechanisms for this remain poorly described. Factor VIII is a procoagulant factor that increases during inflammation and cleaved by activated protein C. To our knowledge, there only 1 prior study of functional C activity in critically COVID-19. Here, we present case series 10 COVID-19 who had severe elevations low normal activity, which may contributed hypercoagulability.
Objectives: Whole blood lactate concentration is widely used in shock states to assess perfusion. We aimed determine if the change plasma renin over time would be superior for predicting in-hospital mortality hypotensive patients on vasopressors. Design: Prospective, observational cohort study. Setting: Tertiary academic ICU. Patients: Adult vasopressors greater than 6 hours maintain a mean arterial pressure or equal 65 mm Hg during January 2020. Interventions: Plasma concentrations were...
BACKGROUND: There is a paucity of data on the underlying procoagulant–anticoagulant balance during extracorporeal membrane oxygenation (ECMO). We hypothesized that adult ECMO patients would have an imbalance between procoagulant and anticoagulant factors, leading to abnormal thrombin generation (TG) pattern. METHODS: Twenty venoarterial (VA) had factor levels measured temporally day 1 or 2, 3, 5. In heparin-neutralized plasma, TG patterns, sensitivity activated protein C were assessed using...
The use of extracorporeal membrane oxygenation (ECMO) as a rescue therapy for cardiopulmonary failure is expanding in critical care medicine. In this case series, we describe the clinical outcomes 21 consecutive pregnant or postpartum patients that required venovenous (VV) venoarterial (VA) ECMO. Our objective was to characterize maternal and fetal survival peripartum ECMO better understand ECMO-related complications occur unique patient population.Between January 2009 June 2019, all treated...
High-dose catecholamines can impair hypoxic pulmonary vasoconstriction and increase shunt fraction. We aimed to determine if Angiotensin II (Ang-2) is associated with improved PaO2/FiO2 SpO2/FiO2 in patients shock.Adult at four tertiary care centers one community hospital the United States who received Ang-2 from July 2018-September 2020 were included this retrospective, observational cohort study. PaO2, SpO2, FiO2 measured 13 timepoints during 48-h before after initiation. Piecewise linear...
Secondary neoplasms of the urinary bladder are uncommon, with metastatic tumors being an even rarer event. The authors studied clinicopathology 11 cases to bladder, which were collected from their archives between 1995 and 2010. most common metastases in this series breast. Some unusual metastases, including several not previously reported, also presented, namely, ileal carcinoid tumor, gastrointestinal stromal ovarian squamous carcinoma, pancreatic gastrinoma, renal collecting duct...
Introduction: Angiotensin II (Ang-2) is a non-catecholamine vasopressor that targets the renin-angiotensin-aldosterone system by agonism of angiotensin type 1 receptor. Its utility as and catecholamine-sparing agent was demonstrated in pivotal ATHOS-3 trial, numerous post-hoc analyses have shown reduced mortality certain subsets population. Methods: Consecutive adult patients at 5 centers who received Ang-2 from 2017-2020 were included this multicenter, retrospective observational cohort...
Coronavirus disease 2019 (COVID-19) first appeared in Wuhan, China, early December 2019.1 Since then, the World Health Organization has classified it as a pandemic and, of April 16, 2020, 186 countries have reported over 2 million confirmed cases and 138,000 deaths.2 In cohort patients with severe disease, 89.0% were hospitalized 8.1% died.1 subgroup admitted to intensive care unit (ICU), required mechanical ventilation, or died from 11.9% continuous renal replacement therapy (RRT), 13.4%...
Background: Patients supported on mechanical circulatory support devices experience vasodilatory hypotension due to high surface area exposure nonbiological and non-endothelialized surfaces. Angiotensin II has been studied in general settings of shock, however concerns exist regarding the use this vasopressor patients with pre-existing cardiac failure. The objective study was assess systemic central hemodynamic effects angiotensin primary or respiratory failure requiring treatment devices....
This study aimed to collect evidence on the structural and substantive validity, test-retest reliability of Chinese version Oswestry Disability Index (CODI). Seventy-nine patients suffering from chronic low back pain were assessed with CODI. The results explorative factor analysis primarily suggested a single-factor structure nine out 10 items (factor loading = 0.66-0.79). sex life item was found load different factor. Cronbach's alpha all 0.81 (p<0.05). When removed analysis, value...
Angiotensin (AT) II is an endogenous hormone that acts on venous and arterial smooth muscle to cause vasoconstriction. Recent trials have sparked great interest in its ability be used as a vasopressor for catecholamine-refractory hypotension. Herein, we describe the successful use of AT patient with colonic perforation septic shock refractory conventional treatment. After initiation, there was immediate reduction catecholamine requirement, survived.