A5043418624- Biochemical Analysis and Sensing Techniques
- Regulation of Appetite and Obesity
- Olfactory and Sensory Function Studies
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Advanced Chemical Sensor Technologies
- Diet, Metabolism, and Disease
- Meat and Animal Product Quality
- Genetic Mapping and Diversity in Plants and Animals
- Neuroscience and Neuropharmacology Research
- Sodium Intake and Health
- Hormonal Regulation and Hypertension
- Biochemical effects in animals
- Cannabis and Cannabinoid Research
- Nutrition, Genetics, and Disease
- Stress Responses and Cortisol
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic function and diabetes
- RNA and protein synthesis mechanisms
- Genetic and phenotypic traits in livestock
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Vitamin D Research Studies
- Neuroscience of respiration and sleep
- Ion Transport and Channel Regulation
Monell Chemical Senses Center
2013-2024
Pontifícia Universidade Católica do Rio Grande do Sul
2023
Temple University
2017
Japan Fisheries Research and Education Agency
2009
Tokyo University of Pharmacy and Life Sciences
2009
Yale University
1999
Kansas State University
1996
University of Pennsylvania
1990-1993
University of California, Los Angeles
1982-1984
Wadsworth Center
1983
Different patterns of foot shock activate opioid and nonopioid mechanisms stress analgesia in the rat. Opioid, but not nonopioid, is reduced by adrenal demedullation denervation potentiated reserpine, a drug known to increase concentrations medullary enkephalin-like peptides. It suggested that enkephalins mediate analgesia.
The results of recent studies suggest that the mouse Sac (saccharin preference) locus is identical to Tas1r3 (taste receptor) gene. goal this study was identify sequence variants associated with saccharin preference in a large number inbred strains. Initially, we sequenced ∼6.7 kb gene and its flanking regions from six strains high low preference, including which alleles were described originally (C57BL/6J, b ; DBA/2J, d ). Of 89 detected among these strains, eight polymorphic sites...
We examined the contribution of experimental factors to hepatic control food intake. Rats with either portal or jugular catheters were infused four times glucose (4.5 mg/min) and equitonic saline (2 ml/2 h). During infusions their contained nonnutritive chocolate chicken flavor, depending on infusate received. Hepatic decreased intake relative no infusion conditions, but did not. When allowed choose between flavors associated each infusate, rats preferred flavor eaten during infusion, showed...
Abstract Human WNT10A mutations are associated with developmental tooth abnormalities and adolescent onset of a broad range ectodermal defects. Here we show that β-catenin pathway activity adult epithelial progenitor proliferation reduced in the absence WNT10A, identify Wnt-active self-renewing stem cells affected tissues including hair follicles, sebaceous glands, taste buds, nails sweat ducts. mouse mutant palmoplantar tongue epithelia also display specific differentiation defects mimicked...
Mice of the C57BL/6ByJ (B6) and 129/J (129) strains were offered different concentrations taste solutions in 48‐hr, two‐bottle choice tests. In comparison with 129 strain, B6 strain had higher preferences for ethanol, sucrose, citric acid. They lower NaCl similar capsaicin quinine hydrochloride. These data are consistent hypothesis that ethanol intake by mice depends, part, on hedonic attractiveness its sweet component.
To determine whether glucose and fat metabolism interact to control food intake, rats were administered 2-deoxyglucose (2-DG), which inhibits utilization, methyl palmoxirate (MP), fatty acid oxidation. Combined treatment with 2-DG MP increased intake in a synergistic fashion. This effect was observed even at doses of the two agents that alone did not increase it expressed by either an initiation eating or prolonged bout eating, depending on testing conditions. Metabolic measures circulating...
During a search for obesity candidate genes in small region of the mouse genome, we noticed that many when knocked out influence body weight. To determine whether this was general feature gene knockout or chance occurrence, surveyed Jackson Laboratory Mouse Genome Database strains and their phenotypes. Body weights were not available all so also obtained weight information by contacting random sample investigators responsible strain. We classified each strain as (1) lighter smaller, (2)...
Calcium and magnesium are essential for survival but it is unknown how animals detect consume enough of these minerals to meet their needs. To investigate this, we exploited the PWK/PhJ (PWK) strain mice, which, in contrast C57BL/6J (B6) other inbred strains, displays strong preferences calcium solutions. We found that PWK also has MgCl2 saccharin solutions not representative salty, sour, bitter, or umami taste compounds. A genome scan B6 x F2 mice linked a component difference preference...
We explored genetic influences on the perception of taste and smell stimuli. Adult twins rated chemosensory aspects water, sucrose, sodium chloride, citric acid, ethanol, quinine hydrochloride, phenylthiocarbamide (PTC), potassium calcium cinnamon, androstenone, Galaxolide™, cilantro, basil. For most traits, individual differences were stable over time some traits heritable (h2 from 0.41 to 0.71). Subjects genotyped for 44 single nucleotide polymorphisms within near genes related smell. The...
Obesity paradox (OP) describes a widely observed clinical finding of improved cardiovascular fitness and survival in some overweight or obese patients. The molecular mechanisms underlying OP remain enigmatic partly due to lack animal models mirroring Using apolipoprotein E knock-out (apoE−/−) mice on high fat (HF) diet as an atherosclerotic obesity model, we demonstrated 1) microRNA-155 (miRNA-155, miR-155) is significantly up-regulated the aortas apoE−/− mice, miR-155 deficiency inhibits...
Many animals can detect the taste of calcium but it is unclear how or whether humans have this ability. We show here that activates hTAS1R3-transfected HEK293 cells and response attenuated by lactisole, an inhibitor hT1R3. Moreover, trained volunteers report lactisole reduces intensity lactate. Thus, taste, T1R3 a receptor responsible for reduce perception acting on T1R3.
This article presents the proceedings of a symposium at 2002 RSA/ISBRA Meeting in San Francisco, California, co-organized by Julie A. Mennella and Alexander Bachmanov Monell Chemical Senses Center. The goal this was to review role that chemosensory factors (taste, smell, chemical irritation) play perception, preference, consumption alcohol. presented research focused on both humans laboratory animals used variety approaches including genetic, developmental, pharmacological, behavioral,...