A5065585143- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Biochemical Analysis and Sensing Techniques
- Cholinesterase and Neurodegenerative Diseases
- Wnt/β-catenin signaling in development and cancer
- Vascular Anomalies and Treatments
- Endoplasmic Reticulum Stress and Disease
- Olfactory and Sensory Function Studies
- Sirtuins and Resveratrol in Medicine
- Autophagy in Disease and Therapy
- Tryptophan and brain disorders
- Cellular transport and secretion
- Nuclear Receptors and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Vascular Malformations and Hemangiomas
- Cancer-related gene regulation
- S100 Proteins and Annexins
- Computational Drug Discovery Methods
- Metabolism, Diabetes, and Cancer
- Prion Diseases and Protein Misfolding
- Protease and Inhibitor Mechanisms
- Ubiquitin and proteasome pathways
- 14-3-3 protein interactions
- Biochemical effects in animals
- Genetics and Neurodevelopmental Disorders
Feinstein Institute for Medical Research
2016-2025
Northwell Health
2013-2025
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2019-2024
Hofstra University
2017-2023
Albert Einstein College of Medicine
2005-2012
Icahn School of Medicine at Mount Sinai
1999-2011
IJ Research (United States)
2005-2008
Institut de Pharmacologie Moléculaire et Cellulaire
1997-2006
Centre National de la Recherche Scientifique
1996-2006
Kagoshima University
2001
Several epidemiological studies indicate that moderate consumption of wine is associated with a lower incidence Alzheimer's disease. Wine enriched in antioxidant compounds potential neuroprotective activities. However, the exact molecular mechanisms involved beneficial effects intake on neurodegenerative process disease brain remain to be clearly defined. Here we show resveratrol (<i>trans</i>-3,4′,5-trihydroxystilbene), naturally occurring polyphenol mainly found grapes and red wine,...
Alzheimer disease is an age-related neurodegenerative disorder characterized by amyloid-β (Aβ) peptide deposition into cerebral amyloid plaques. The natural polyphenol resveratrol promotes anti-aging pathways via the activation of several metabolic sensors, including AMP-activated protein kinase (AMPK). Resveratrol also lowers Aβ levels in cell lines; however, underlying mechanism responsible for this effect largely unknown. Moreover, bioavailability brain remains uncertain. Here we show...
J. Neurochem. (2012) 120 , 461–472. Abstract Activation of microglia, the resident macrophages brain, around amyloid plaques is a key hallmark Alzheimer’s disease (AD). Recent evidence in mouse models indicates that microglia are required for neurodegenerative process AD. Amyloid‐β (Aβ) peptides, core components plaques, can trigger microglial activation by interacting with several Toll‐like receptors (TLRs), including TLR4. In this study, we show resveratrol, natural polyphenol associated...
Calcium is a key signaling ion involved in many different intracellular and extracellular processes ranging from synaptic activity to cell-cell communication adhesion. The exact definition at the molecular level of versatility this has made overwhelming progress past several years been extensively reviewed. In brain, calcium fundamental control memory formation, process that leads activation specific calcium-dependent signal transduction pathways implicates protein effectors, such as CaMKs,...
The AMP-activated protein kinase (AMPK) is a Ser/Thr that activated in response to low-energy states coordinate multiple signaling pathways maintain cellular energy homeostasis. Dysregulation of AMPK has been observed Alzheimer's disease (AD), which associated with abnormal neuronal metabolism. In the current study we tested hypothesis aberrant underlies AD-associated synaptic plasticity impairments by using pharmacological and genetic approaches. We found amyloid β (Aβ)-induced inhibition...
Extracellular Ca 2+ (Ca o ) plays important roles in physiology. Changes of concentration ([Ca ] have been observed to modulate neuronal excitability various physiological and pathophysiological settings, but the mechanisms by which neurons detect [Ca are not fully understood. Calcium homeostasis modulator 1 (CALHM1) expression was shown induce cation currents cells elevate cytoplasmic i response removal its subsequent addback. However, it is unknown whether CALHM1 a pore-forming ion channel...
Abstract Neurofibrillary tangles (NFTs) are the pathological hallmark of neurodegenerative diseases commonly known as tauopathies. NFTs result from intracellular aggregation abnormally and hyperphosphorylated tau proteins. Tau functions, which include regulation microtubules dynamics, dependent on its phosphorylation status. As a consequence, any changes in can have major impacts synaptic plasticity memory. Recently, it has been demonstrated that AMP-activated protein kinase (AMPK) was...
Here we show that presenilin-1 (PS1), a protein involved in Alzheimer's disease, binds directly to epithelial cadherin (E-cadherin). This binding is mediated by the large cytoplasmic loop of PS1 and requires membrane-proximal sequence 604–615 mature E-cadherin. also required for E-cadherin p120, known regulator cadherin-mediated cell adhesion. Using wild-type knockout cells, found increasing levels suppresses p120/E-cadherin binding, p120 PS1/E-cadherin binding. Thus bind mutually compete...
Conventional chemical synapses in the nervous system involve a presynaptic accumulation of neurotransmitter-containing vesicles, which fuse with plasma membrane to release neurotransmitters that activate postsynaptic receptors. In taste buds, type II receptor cells do not have conventional synaptic features but nonetheless show regulated their afferent neurotransmitter, ATP, through large-pore, voltage-gated channel, CALHM1. Immunohistochemistry revealed CALHM1 was localized points contact...
Hereditary hemorrhagic telangiectasia (HHT), a genetic bleeding disorder leading to systemic arteriovenous malformations (AVMs), is caused by loss-of-function mutations in the ALK1/ENG/Smad1/5/8 pathway. Evidence suggests that HHT pathogenesis strongly relies on overactivated PI3K/Akt/mTOR and VEGFR2 pathways endothelial cells (ECs). In BMP9/10-immunoblocked (BMP9/10ib) neonatal mouse model of HHT, we report here mTOR inhibitor, sirolimus, receptor tyrosine kinase nintedanib, could...
AMP-activated protein kinase (AMPK) is a sensor and regulator of cellular energy metabolism potentially Implicated In broad range conditions, including obesity Alzheimer's disease. Its role in the control key metabolic enzymes makes this central player glucose lipid homeostasis. Recently, by screening library synthetic small molecules selected for their structural similarity with natural polyphenol resveratrol, we identified RSVA314 RSVA405 as potent indirect activators AMPK (half-maximal...
The endocannabinoid CB₂ receptor system has been implicated in the neuropathology of Alzheimer's disease (AD). In order to investigate impact on AD pathology, a colony mice with deleted gene, CNR2, was established transgenic human mutant APP background for pathological comparison receptor-sufficient mice. J20 (PDGFB-APPSwInd) were bred over two generations CNR2⁻/⁻ (Cnr2(tm1Dgen)/J) produce CNR2⁺/⁺ and Seventeen (12 females, 5 males) 16 (11 killed at 12 months, their brains interrogated...