A5040022220- Biochemical Analysis and Sensing Techniques
- Olfactory and Sensory Function Studies
- Advanced Chemical Sensor Technologies
- Asthma and respiratory diseases
- Virus-based gene therapy research
- Coaching Methods and Impact
- Herpesvirus Infections and Treatments
- Immune Cell Function and Interaction
- Animal Virus Infections Studies
- Sinusitis and nasal conditions
- RNA Interference and Gene Delivery
- Orthodontics and Dentofacial Orthopedics
- Cystic Fibrosis Research Advances
- Dental Radiography and Imaging
- Antimicrobial Peptides and Activities
- Immunodeficiency and Autoimmune Disorders
- Respiratory and Cough-Related Research
- Microbial Metabolic Engineering and Bioproduction
- Receptor Mechanisms and Signaling
- Neonatal Respiratory Health Research
- Pediatric health and respiratory diseases
- Language and cultural evolution
- Monoclonal and Polyclonal Antibodies Research
- Bone Tumor Diagnosis and Treatments
- Intensive Care Unit Cognitive Disorders
University of Pennsylvania
2016-2025
University of Edinburgh
1993-2023
Pharmac
2023
University of California, San Francisco
2017-2022
Hospital of the University of Pennsylvania
2020-2022
University of Exeter
2010-2022
The Ohio State University
2000-2022
University of California, Irvine
2022
California University of Pennsylvania
2020
Bath and North East Somerset Council
2018
Reports of clinical trials often contain a wealth data comparing treatments. This can lead to problems in interpretation, particularly when significance testing is used extensively. We examined 45 reports comparative published the British Medical Journal, Lancet, or New England Journal Medicine illustrate these statistical problems. The issues we considered included analysis multiple end points, repeated measurements over time, subgroup analyses, treatments, and overall number tests trial...
Innate and adaptive defense mechanisms protect the respiratory system from attack by microbes. Here, we present evidence that bitter taste receptor T2R38 regulates mucosal innate of human upper airway. Utilizing immunofluorescent live cell imaging techniques in polarized primary sinonasal cells, demonstrate is expressed epithelium activated response to acyl-homoserine lactone quorum-sensing molecules secreted Pseudomonas aeruginosa other gram-negative bacteria. Receptor activation...
Bitter taste receptors (T2Rs) in the human airway detect harmful compounds, including secreted bacterial products. Here, using primary sinonasal air-liquid interface cultures and tissue explants, we determined that activation of a subset T2Rs expressed nasal solitary chemosensory cells activates calcium wave propagates through gap junctions to surrounding respiratory epithelial cells. The T2R-dependent stimulated robust secretion antimicrobial peptides into mucus was capable killing variety...
The aim of this study was to investigate the relationships between plasma concentrations losartan, an orally active angiotensin II inhibitor, its metabolite EXP3174, and blockade. Six healthy subjects received single oral doses 40, 80, or 120 mg losartan placebo at 1-week intervals in a crossover study. Angiotensin blockade assessed by blood pressure response exogenous before after administration. EXP3174 reached higher eliminated more slowly than parent compound; levels paralleled profile...
Biofuels are the most immediate, practical solution for mitigating dependence on fossil hydrocarbons, but current biofuels (alcohols and biodiesels) require significant downstream processing not fully compatible with modern, mass-market internal combustion engines. Rather, ideal structurally chemically identical to fuels they seek replace (i.e., aliphatic n - iso -alkanes -alkenes of various chain lengths). Here we report production such petroleum-replica hydrocarbons in Escherichia coli ....
Abstract Clinical trials have proven oncolytic virotherapy to be safe but not effective. We shown that viruses (OV) injected into intracranial gliomas established in rodents are rapidly cleared, and this is associated with up-regulation of markers (CD68 CD163) cells monocytic lineage (monocytes/microglia/macrophages). However, it unclear whether these directly impede intratumoral persistence OV through phagocytosis they infiltrate the tumor from blood or brain parenchyma. To investigate...
Fresh frozen plasma (FFP) is widely used, but few studies have described patterns of use in critical care. We carried out a multicentre study coagulopathy intensive care units (ICUs) and here describe overall FFP utilisation adult care, the indications for transfusions, factors indicating doses used effects on coagulation.We conducted prospective, multicentre, observational all patients sequentially admitted to 29 UK general ICUs over 8 weeks. Daily data throughout ICU admission were...
Background The bitter taste receptor T2R38 was recently described to play a role in upper airway innate mucosal defense. When activated by bacterial quorum‐sensing molecules, stimulates the ciliated epithelial cells produce nitric oxide (NO), resulting bactericidal activity and an increase mucociliary clearance (MCC). Polymorphisms within gene ( TAS2R38 ) confer variability activation of yielding dramatic differences defensive responses (NO production accelerated MCC) microbial stimulation...
Abstract The popularity of executive coaching has increased dramatically in both the practitioner world and academia during past decade. However, evaluating effectiveness lagged behind. Executive is a multidisciplinary practice, professionals from many different scholarly backgrounds provide services. paucity empirical research may be attributed to lack consensus among these divergent regarding whether how evaluate coaching. In this article, we conducted meta-analysis as well reviewed...
Extracellular Ca 2+ (Ca o ) plays important roles in physiology. Changes of concentration ([Ca ] have been observed to modulate neuronal excitability various physiological and pathophysiological settings, but the mechanisms by which neurons detect [Ca are not fully understood. Calcium homeostasis modulator 1 (CALHM1) expression was shown induce cation currents cells elevate cytoplasmic i response removal its subsequent addback. However, it is unknown whether CALHM1 a pore-forming ion channel...
ICU survivors frequently report reduced health-related quality of life, but the relative importance preillness versus acute illness factors in survivor populations is not well understood. We aimed to explore life trajectories over 12 months following discharge, patterns improvement, or deterioration this period, and demographics (age, gender, social deprivation), preexisting health (Functional Comorbidity Index), severity (Acute Physiology Chronic Health Evaluation II score, ventilation...
Staphylococcus -derived d -amino acids reduce innate immune responses in the nasal epithelium by stimulating sweet taste receptor.
Osteosarcoma of the jaws is rare and clinically distinct from osteosarcoma long bones body with different treatment outcomes. The literature on these tumors limited to case reports small series mostly single institutions. We used data population-based national Surveillance, Epidemiology End Results (SEER) cancer registry determine epidemiology prognostic factors associated jaws.To investigate epidemiologic characteristics for survival in patients diagnosed jaws.A retrospective, cohort study...