A5034833317- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cancer-related molecular mechanisms research
- Cervical Cancer and HPV Research
- PARP inhibition in cancer therapy
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- Cancer Cells and Metastasis
- RNA Research and Splicing
- HVDC Systems and Fault Protection
- Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Neutropenia and Cancer Infections
- Renal cell carcinoma treatment
- Epigenetics and DNA Methylation
- Viral-associated cancers and disorders
- Colorectal and Anal Carcinomas
- Cancer-related gene regulation
- AI in cancer detection
- Molecular Biology Techniques and Applications
- Management of metastatic bone disease
Chongqing Cancer Hospital
2016-2025
Chongqing University
2018-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2025
Shanghai Stomatological Hospital
2025
Tongji University
2025
Cancer Institute (WIA)
2025
Chongqing Medical University
2016-2020
Beckman Research Institute
2019
University of Cincinnati
2017-2019
City of Hope
2019
Abstract N 6-Methyladenosine (m6A) is the most abundant RNA modification in mammal mRNAs and increasing evidence suggests key roles of m6A human tumorigenesis. However, whether m6A, especially its ‘reader’ YTHDF1, targets a gene involving protein translation thus affects overall production cancer cells largely unexplored. Here, using multi-omics analysis for ovarian cancer, we identified novel mechanism EIF3C, subunit initiation factor EIF3, as direct target YTHDF1. YTHDF1 augments EIF3C an...
Importance The efficacy of niraparib maintenance therapy with an individualized starting dose (ISD) warrants further investigation in a broad population newly diagnosed advanced ovarian cancer (aOC), including patients without postoperative residual disease. Objective To evaluate the and safety ISD aOC (R0 resection permitted). Design, Setting, Participants This multicenter, randomized, double-blind, placebo-controlled, phase 3 study was conducted China enrolled 384 who received primary or...
Abstract Ovarian cancer is the leading cause of gynecological cancer-related death. Drug resistance bottleneck in ovarian treatment. The increasing use novel drugs clinical practice poses challenges for treatment drug-resistant cancer. Continuing to classify drug according type without understanding underlying mechanisms unsuitable current practice. We reviewed literature regarding various and found that main are as follows: abnormalities transmembrane transport, alterations DNA damage...
Abstract Background Since FTO was recognized as the first m 6 A demethylase, understanding of its biological function has been widely expanded. However, role in cervical cancer tumorigenesis remains unclear. Methods In this study, we analyzed expression two independent human datasets and evaluated correlation between level progression. Using small hairpin RNA technology, explored cell line Hela SiHa cells, respectively. We then determined targets by performing transcriptional profile with...
Abstract Strand-selection is the final step of microRNA biogenesis in which functional mature miRNAs are generated from one or both arms precursor. The preference strand-selection diverse during development and tissue formation, however, its pathological effect still unknown. Here we find that two miRNA same precursor, miR-574-5p miR-574-3p, inversely expressed play exactly opposite roles gastric cancer progression. Higher-5p with lower-3p expression pattern significantly correlated higher...
Cervical cancer (CC) that is caused by high-risk human papillomavirus (HPV) remains a significant public health problem worldwide. HPV integration sites can be silent or actively transcribed, leading to the production of viral-host fusion transcripts. Herein, we demonstrate only productive were nonrandomly distributed across both viral and host genomes, suggesting are under selection likely contribute CC pathophysiology. Furthermore, using large-scale, multi-omics (clinical, genomic,...
Homoharringtonine, a plant alkaloid, has been reported to suppress protein synthesis and approved by the US Food Drug Administration for treatment of chronic myeloid leukemia. Here we show that in acute leukemia (AML), homoharringtonine potently inhibits cell growth/viability induces cycle arrest apoptosis, significantly disease progression vivo, substantially prolongs survival mice bearing murine or human AML. Strikingly, dramatically decreases global DNA 5-hydroxymethylcytosine abundance...
Background MicroRNAs act as posttranscriptional regulators of gene expression in many biological processes. Their deregulations occur commonly gastric cancer (GC). Although DNA methylation constitutes an important mechanism for microRNA deregulation cancer, this field largely remains unexplored. Methodology/Principal Findings Total RNA was extracted from the tissues 100 patients with GC and four cell lines. The levels miR-10a were determined by real-time PCR specific TaqMan probes. Moreover,...
Abstract Background Cancer stem cells (CSCs) are the root of human cancer development and major cause treatment failure. Aberrant elevation SOX4, a member SOX (SRY-related HMG-box) family transcription factors, has been identified in many types promotes development. However, role SOX4 CSCs, especially at proteome-wide level, remained elusive. The aim this study is to investigate effect on stemness CSCs reveal underlying mechanisms by identification SOX4-induced proteome changes through...
Long-term use of low-toxic natural products holds the promise for eradicating cancer stem cells. In this study, we report that luteolin, a flavonoid, attenuates stemness ovarian cells (OCSCs) by directly binding to KDM4C and epigenetic suppression PPP2CA/YAP axis. Ovarian like (OCSLCs) isolated suspension culture CD133 + ALDH+ cell sorting was employed as OCSCs model. The maximal non-toxic dose luteolin suppressed properties, including sphere-forming capacity, expression markers,...
The molecular classification of endometrial cancer (EC), as proposed by Cancer Genome Atlas (TCGA), has transformed tumor classification, but there is a lack extensive research on the profiles and subtyping patients in China. 200 EC were classified into following four types: (i) POLEmut; (ii) MSI-H; (iii) TP53mut; (iv) NSMP. This study aimed to investigate characteristics at single center large-scale next generation sequencing(NGS), including clinicopathological features gene mutations with...
Para-aortic lymph node (PALN) metastasis of patients with locally advanced cervical cancer (LACC) is associated multiple risk factors. This study aimed to identify factors and develop a predictive model for PALN based on the pathological diagnosis via surgical staging determine patient-population suitable extended-field irradiation (EFRT) clarify prognosis LACC. Five parameters were identified as predictors by logistic regression analysis. The was displayed nomogram then modified into simple...
<title>Abstract</title> Objective To investigate the prognostic value of magnetic resonance imaging (MRI) and clinical features in locally advanced cervical cancer (LACC) after concurrent chemoradiotherapy (CCRT). Method This study recruited 189 patients with LACC who received definitive CCRT between May 2018 December 2020 underwent MRI, including diffusion-weighted imaging, before 1 month initial therapy. The tumor size mean apparent diffusion coefficient (ADC<sub>mean</sub>) values were...
Increasing evidences have documented that microRNAs (miRNAs) act as oncogenes or tumor suppressors in gastric cancer (GC). In this study, we aimed to investigate the expression of miR-133b a large number GC samples and elucidate its role carcinogenesis detailed mechanism. We used Taqman probe stem-loop real-time PCR accurately measure levels 100 pairs tissues adjacent non-neoplastic tissues. mimics were overexpressed cell lines, inhibitors also introduced GES cells on regulating...