A5101706724- Cancer-related gene regulation
- RNA modifications and cancer
- Anaerobic Digestion and Biogas Production
- Wnt/β-catenin signaling in development and cancer
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Membrane Separation Technologies
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Genomics and Diagnostics
- Renin-Angiotensin System Studies
- Cancer Cells and Metastasis
- Esophageal and GI Pathology
- Corneal Surgery and Treatments
- Cancer therapeutics and mechanisms
- Cancer-related Molecular Pathways
- Esophageal Cancer Research and Treatment
- Ocular Surface and Contact Lens
- Endometrial and Cervical Cancer Treatments
- Chromatography in Natural Products
- Traditional and Medicinal Uses of Annonaceae
- Histiocytic Disorders and Treatments
- Chemical synthesis and alkaloids
- Hippo pathway signaling and YAP/TAZ
- Microtubule and mitosis dynamics
- Alzheimer's disease research and treatments
Chongqing University
2023-2025
Tianjin Medical University
2023-2025
Tianjin Medical University Eye Hospital
2024-2025
Fujian Medical University
2023-2025
Chongqing Cancer Hospital
2023-2025
Cancer Institute (WIA)
2025
Second Hospital of Tianjin Medical University
2023-2024
Guangzhou University of Chinese Medicine
2022
Fujian University of Traditional Chinese Medicine
2019-2022
China Pharmaceutical University
2011-2019
Background: HAUS6 participates in microtubule-dependent microtubule amplification, but its role malignancies including colorectal cancer (CRC) has not been explored. We therefore assessed the potential oncogenic activities of CRC. Results: mRNA and protein expression is higher CRC tissues, high correlated with shorter overall survival patients. knockdown cell lines suppressed growth vitro vivo by inhibiting viability, arresting cycle progression at G0/G1, while over-expression increased...
Abstract The RNA-binding protein PNO1 is critical for ribosome biogenesis, but its potential role in cancer remains unknown. In this study, online data mining, cDNA, and tissue microarrays indicated that expression was higher colorectal than noncancerous tissue, overexpression associated with worse patient survival. Gain-of-function loss-of-function studies demonstrated knockdown suppressed growth of cells vitro vivo, while promoted cell proliferation vitro. expressing wild-type p53,...
Objective This study aimed to explore the association between dietary antioxidant index (DAI) combined with serum albumin-to-globulin ratio (AGR) and postoperative Health-related quality of life (HRQOL) in patients esophageal squamous cell carcinoma (ESCC). Methods All were newly diagnosed ESCC underwent radical esophagectomy. Dietary data routine blood tests collected preoperatively compute DAI AGR. HRQOL was assessed over 7 years post-surgery via telephone follow-up analyzed longitudinally...
<title>Abstract</title> Objective To investigate the prognostic value of magnetic resonance imaging (MRI) and clinical features in locally advanced cervical cancer (LACC) after concurrent chemoradiotherapy (CCRT). Method This study recruited 189 patients with LACC who received definitive CCRT between May 2018 December 2020 underwent MRI, including diffusion-weighted imaging, before 1 month initial therapy. The tumor size mean apparent diffusion coefficient (ADC<sub>mean</sub>) values were...
Podophyllotoxin has long been used as an active substance for cytotoxic activity. Fourteen novel biotinylated podophyllotoxin derivatives were designed, synthesized, and evaluated activity this study. The synthesized compounds in the following human cancer cell lines, SW480, MCF-7, A-549, SMMC-7721, HL-60 by MTT assay. Most of them exhibited potent effects compound 15 showed highest among five lines tested, having its IC50 values range 0.13 to 0.84 μM. Apoptosis analysis revealed that caused...
Abstract Objective This study aimed to investigate the effect of preoperative albumin-to-globulin ratio (AGR) on overall survival (OS) and health-related quality life in patients with esophageal cell squamous carcinoma (ESCC). Methods Serum albumin globulin were measured within one week before surgery. Multiple follow-ups conducted among ESCC order assess their quality. The method used was a telephone interview. Quality using EORTC Life Questionnaire-Core Questionnaire (EORTC QLQ-C30,...
The protective role of alkaloids from Nelumbinis Plumula (AFNP) on the aorta during hypertension is not yet fully understood. We hypothesize that AFNP exerts effects against Ang II-induced by mediating RhoA/ROCK pathway and phenotypic switching hypertension. In present study, we evaluated effect angiotensin II (Ang II)-induced actin cytoskeleton reorganization remodeling, as well involvement RhoA/Rho-associated coiled kinase (ROCK) in protecting used rat aortic tissues to investigate...
Pituitary homeobox 2 (PITX2) is a homeodomain transcription factor that has substantial role in cell proliferation and differentiation various tissues. In this report, we have conducted systematic study, using proteomic genomic approaches, to characterize PITX2-interacting proteins PITX2-regulating genes. We identified four novel PITX2-associated protein partners Y box binding factor-1, heterogeneous ribonucleoprotein K, nucleolin nuclear U mass spectrometry analysis. also found...
Abstract Purpose Establishment of sister chromatid cohesion N-acetyltransferase 2 (ESCO2) is involved in the mitotic S-phase adhesins acetylation and responsible for bridging two chromatids. However, present ESCO2 cancer research limited to a few cancers. No systematic pan-cancer analysis has been conducted investigate its role diagnosis, prognosis, effector function. Methods We thoroughly examined carcinogenesis by combining public databases such as The Cancer Genome Atlas (TCGA),...
The Qingda granule (QDG) formulation was simplified from the Qingxuan Jiangya Decoction, which has been used in China to treat hypertension for decades. However, molecular mechanisms of QDG antihypertension remain largely unknown. Therefore, we evaluated therapeutic efficacy against elevated blood pressure and explored its underlying mechanism. treatment decreased increased vascular elasticity thoracic aortic rings KCl stimulation spontaneously hypertensive rats. relaxation isolated...
This study evaluated the potential pharmacokinetic interaction of pamapimod, a p38 mitogen-activated protein kinase inhibitor, and methotrexate (MTX) when administered concomitantly in patients with rheumatoid arthritis (RA); also pharmacodynamic effects pamapimod. Twenty-two RA on stable regimen MTX (10-25 mg/wk; days 1 8) were randomized to receive 300 mg pamapimod (n = 17) or placebo 5) once daily (qd) for 10 (days 5-14). Blood urine samples collected pre- postdose (MTX alone), 7...
PTEN (phosphatase and tensin homologue deleted on chromosome ten) plays critical roles in multiple cellular processes, including cell proliferation, survival, migration transformation. A role of mammalian spermatogenesis, however, has not been explored. To address this question, we generated a mouse model with conditional knockout postnatal male germ cells. We found that spermatogenesis was normal PTEN-deleted mutant males produced sperm sired offspring as competently wild-type littermates....
Anaerobic co-digestion has been considered to be a promising energy-producing process for kitchen waste and excess sludge treatment. However, the investigation of hydrolysis performance is still required further improvement this process. In study, results indicated that model can enhance system stability during phase. The pH group remained stable at 6.94–7.18, which had better buffer capacity compared group. maximum value dehydrogenase activity was 949 TF μg/(L h) in group, 105% 30% higher...
Background. Colorectal cancer liver metastasis (CRLM) is a high degree of malignancy with rapid disease progression and has poor prognosis. Both serum apolipoprotein A-I (ApoA-I) neutrophil-to-lymphocyte ratio (NLR) play key roles in anti-inflammation antitumor. This study aimed at evaluating the implication ApoA-I level combination NLR prognosis CRLM. Methods. We retrospectively analyzed 237 patients Cox regression analyses were used to identify independent prognostic significance these...
Meibomian gland dysfunction is a chronic ocular surface disease with complex pathogenesis, whose main clinical manifestations are meibomian obstruction or/and lipid abnormalities. To explore the mechanism of MGD due to (MGO), we established rat model MGO by cauterizing orifice. The morphology lid margins and orifices were visualized slit lamp. tear production rats was measured phenol red cotton thread, film breakup time corneal fluorescein staining scores detected under cobalt blue light...