A5048994550- Hepatocellular Carcinoma Treatment and Prognosis
- MicroRNA in disease regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Mechanisms and Therapy
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Nanoplatforms for cancer theranostics
- Orthopedic Surgery and Rehabilitation
- Foot and Ankle Surgery
- Vasculitis and related conditions
- IgG4-Related and Inflammatory Diseases
- Lipid metabolism and disorders
- Hepatitis B Virus Studies
- Marine Sponges and Natural Products
- Liver Disease Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Tendon Structure and Treatment
- Caveolin-1 and cellular processes
- Epigenetics and DNA Methylation
- Phytochemical compounds biological activities
- Protein Hydrolysis and Bioactive Peptides
- Extracellular vesicles in disease
- Inflammatory Biomarkers in Disease Prognosis
- Sarcoidosis and Beryllium Toxicity Research
Guangzhou University of Chinese Medicine
2022-2025
Chongqing Medical University
2023-2024
Second Affiliated Hospital of Chongqing Medical University
2023-2024
Dalian Medical University
2023-2024
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2022-2023
Karamay Central Hospital
2023
Guizhou University
2022
To report the efficacy and safety of postoperative adjuvant hepatic arterial infusion chemotherapy (HAIC) with 5-fluorouracil oxaliplatin (FOLFOX) in hepatocellular carcinoma (HCC) patients microvascular invasion (MVI).In this randomized, open-label, multicenter trial, histologically confirmed HCC MVI were randomly assigned (1:1) to receive FOLFOX-HAIC (treatment group) or routine follow-up (control group). The primary end point was disease-free survival (DFS) by intention-to-treat (ITT)...
The high mortality rate from hepatocellular carcinoma (HCC) is due primarily to challenges in early diagnosis and the development of drug resistance advanced stages. Many first-line chemotherapeutic drugs induce ferroptosis, a form programmed cell death dependent on ferrous iron-mediated oxidative stress, suggesting that ensuing tumor progression may part stem reduced ferroptosis. Since circular RNAs (circRNAs) have been shown influence development, we examined whether specific circRNAs...
A 30-year-old man presented to otolaryngology department complaining of nasal congestion and runny nose for six months, with repeated fever, shortness breath.The weight loss in the past 20 days was about 5 kg. At first, he diagnosed respiratory infection treated antibiotics, but it didn't work. Nasopharynx CT scan showed soft tissue thickening without bone destruction, obvious inhomogeneous enhancement. Chest revealed multiple patchy clouding nodules ground-glass opacity poorly-defined...
4023 Background: The efficacy of operation, as the only radical option for resectable BCLC stage A/B hepatocellular carcinoma (HCC) patients beyond Milan criteria, is still unsatisfactory. This study aimed to investigate and safety preoperative neoadjuvant hepatic arterial infusion chemotherapy (HAIC) with FOLFOX regimen these patients. Methods: In this multi-center, prospective, phase 3, randomized, open-labeled, controlled clinical trial, HCC criteria were randomly assigned (1:1) before...
Hepatectomy is the recommended option for radical treatment of BCLC stage A/B hepatocellular carcinoma (HCC) that has progressed beyond Milan criteria. This study evaluated efficacy and safety preoperative neoadjuvant transcatheter arterial chemoembolization (TACE) these patients.In this prospective, randomized, open-label clinical study, HCC patients criteria were randomly assigned (1:1) to receive either TACE prior hepatectomy (NT group) or alone (OP group). The primary outcome was overall...
Studies have shown that Jianpi Huayu Decoction (JPHYD) can inhibit the growth of hepatocellular carcinoma cells, but mechanism its effect was not clear at present. We assessed JPHYD using liver cancer cells as in vitro cell model and xenograft tumor vivo model. CCK8, EdU, wound-healing, transwell assays were performed to assess growth, migration, invasion (HCC) lines HepG2 MHCC97H. Western blot assay observe protein level E-cadherin, Smad7, N-cadherin, Snail, Smad3, Vimentin, Zeb1. qRT-PCR...
Hepatocellular carcinoma (HCC) is one of the leading causes cancer-related death worldwide. Circular RNAs (circRNAs) play critical roles in progression HCC. However, role newly identified circFGGY (hsa_circ_0006633) development and HCC has not been explored. In this study, we found that was significantly downregulated tumor compared with adjacent normal liver tissues patients low expression had poor overall survival after hepatectomy. Moreover, it could inhibit proliferation, invasion...
Aspongopus chinensis Dallas is used as a traditional Chinese medicine well an edible insect. Although its anti-tumor effects have been observed, the active component(s) in hemolymph of A. remains unknown. In this study, combination usage ultrafiltration, gel filtration chromatography, FPLC and RP-HPLC to separate purify peptides was performed based on proliferation human gastric cancer SGC-7901 cell line treated with candidates. One peptide (MW = 2853.3 Da) isolated from chinensis. A total...
Background. Colorectal cancer liver metastasis (CRLM) is a high degree of malignancy with rapid disease progression and has poor prognosis. Both serum apolipoprotein A-I (ApoA-I) neutrophil-to-lymphocyte ratio (NLR) play key roles in anti-inflammation antitumor. This study aimed at evaluating the implication ApoA-I level combination NLR prognosis CRLM. Methods. We retrospectively analyzed 237 patients Cox regression analyses were used to identify independent prognostic significance these...
Hepatocellular carcinoma (HCC) patients experience high rates of recurrence following hepatectomy. Many herbal preparations used in traditional Chinese medicine have been shown to improve the postoperative condition cancer patients. This retrospective study examined efficacy and safety Jianpi Huayu decoction (JPHYD) as adjuvant therapy for HCC received management according Society Clinical Oncology recommendations, either alone (Control group) or addition daily JPHYD (1 week hospital 3...
4013 Background: To report the efficacy and safety of postoperative adjuvant hepatic arterial infusion chemotherapy (HAIC) with FOLFOX (5- fluorouracil, leucovorin, oxaliplatin) in hepatocellular carcinoma (HCC) patients microvascular invasion (MVI). Methods: In this randomized, open label, multicenter, phase 3 trial, histologically confirmed HCC MVI were randomized (1:1) to receive either 1 2 cycles HAIC-FOLFOX (treatment group) or routine follow-up without any treatment (control group)....
Abstract Background This study explores the latest epidemiological characteristics of posterior malleolus fracture and compares differences in different periods, regions, adult age groups. Methods Clinical information inpatients with Shanghai Tongji Hospital Karamay Central from January 2014 to February 2022 was reviewed collected. The imaging data patients were acquired using Picture Archiving Communication Systems. A statistical analysis performed as gender, current age, year admission,...
<title>Abstract</title> The high mortality rate from hepatocellular carcinoma (HCC) is due primarily to challenges in early diagnosis and the development of drug resistance advanced stages. Many first-line chemotherapeutic drugs induce ferroptosis, a form programmed cell death dependent on ferrous iron-mediated oxidative stress, suggesting that ensuing tumor progression may part stem reduced ferroptosis. Since circular RNAs (circRNAs) have been shown influence development, we examined...
Jianpi Huayu decoction (JHD) is a traditional Chinese medicinal preparation used to treat variety of malignant tumors including HCC, although the underlying mechanism remains unknown. Exosomes in tumor microenvironment mediate intercellular signaling among cancer cells, but precise contributions hepatocellular carcinoma (HCC) progression are still elusive.In this work, main objective was examine mechanisms anti-tumor effects JHD and potential exosomal signaling.LC-MS/MS for Quality control...