A5009071255- Chronic Kidney Disease and Diabetes
- Cancer-related molecular mechanisms research
- Chemotherapy-induced organ toxicity mitigation
- Pharmacological Effects of Natural Compounds
- Cancer, Hypoxia, and Metabolism
- Renal cell carcinoma treatment
- RNA modifications and cancer
- Natural Compounds in Disease Treatment
- MicroRNA in disease regulation
- Chemokine receptors and signaling
- Cancer Mechanisms and Therapy
- Immune Cell Function and Interaction
- Angiogenesis and VEGF in Cancer
- Galectins and Cancer Biology
- Head and Neck Surgical Oncology
- Orthodontics and Dentofacial Orthopedics
- Helicobacter pylori-related gastroenterology studies
- HIV Research and Treatment
- Pharmacological Effects and Toxicity Studies
- Craniofacial Disorders and Treatments
- Traditional Chinese Medicine Studies
- Sinusitis and nasal conditions
- Acute Kidney Injury Research
- Metabolism and Genetic Disorders
- Macrophage Migration Inhibitory Factor
First Hospital of China Medical University
2019-2025
China Medical University
2019-2025
Nanjing University of Chinese Medicine
2017-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
Shenyang Center for Disease Control and Prevention
2025
First People's Hospital of Chongqing
2018-2024
Stomatology Hospital
2022-2024
Zhejiang University
2022-2024
Nanjing Medical University
2018-2024
Second Affiliated Hospital of Nanjing Medical University
2018-2024
BackgroundCelastrol is an active ingredient of Chinese medicine Tripterygium wilfordii which clinically used to treat the immune diseases. Currently, celastrol documented as a potent agent for treating cancer and inflammatory disorders. This study was investigate effect on cisplatin nephrotoxicity underlying mechanism.MethodsMale C57BL/6 mice were treated with (20 mg/kg) or without treatment (1 2 mg/kg/day). In vitro, human proximal tubule epithelial cell line (HK−2) mouse renal cells...
Acetaminophen (APAP) overdose causes acute liver injury and leads to fatal damage. However, the therapies are quite limited. Shikonin is a natural product with antioxidant anti-inflammatory activities. In present study, hepatoprotective effects underlying mechanisms of shikonin in APAP-induced hepatotoxicity vivo vitro were investigated. pretreatment models established vitro, as evidenced by serum hepatic enzymes, histological changes, oxidative stress indicators proinflammatory cytokines....
Renal hypoxia occurs in acute kidney injury (AKI) of various etiologies. Activation hypoxia-inducible transcription factor (HIF) has been identified as an important mechanism cellular adaptation to low oxygen. Preconditional HIF activation protects against AKI, suggesting a new approach AKI treatment. is degraded under normoxic conditions mediated by oxygen-dependent hydroxylation specific prolyl residues the regulative α-subunits hydroxylases (PHD). FG-4592 novel, orally active,...
Article11 January 2023Open Access Source DataTransparent process LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease Mi Bai Department of Nephrology, State Key Laboratory Reproductive Medicine, Children's Hospital Nanjing Medical University, Nanjing, China Jiangsu Pediatrics, Contribution: Data curation, Funding acquisition, Validation, Investigation, Visualization, Methodology, Writing - original draft Search for more papers by this author Mengqiu Wu...
Abstract In multiple types of tumors, fibrotic collagen is regarded as the 'highway' for cancer cell migration, which mainly modified by lysyl hydroxylase 2 (PLOD2). The previous findings have demonstrated that expression PLOD2 was regulated factors, including HIF-1 α , TGF- β and microRNA-26a/b. Although confirmed to be related poor prognosis in lung adenocarcinoma, regulatory mechanism function human adenocarcinoma poorly understood. On other hand, upregulation or hyperactivation epidermal...
PXR is crucial for protecting against AKI by targeting the AKR1B7/mitochondrial metabolism axis.
ABSTRACT The latent human immunodeficiency virus (HIV) reservoir presents the biggest obstacle to curing HIV chronic infection. Consequently, finding novel strategies control is critical. Natural killer (NK) cells are essential for antiviral immunity. However, influence of NK cell subsets and their associated inhibitory or activating receptors on cytotoxicity toward has not been fully studied. We investigated relationship between percentage reservoir. Our results indicated that CD56 − CD16 +...
The study was aimed to investigate the clinical effect and mechanism of Shugan-Jieyu-Jianpi (SGJYJP) formula for treatment irritable bowel syndrome (IBS) combined with non-alcoholic fatty liver disease (NAFLD). efficacy SGJYJP evaluated in 54 patients IBS-NAFLD. potential molecular investigated by network pharmacology. Animal models were constructed explore related mechanism. From studies, total effective rate group significantly higher than that pinaverium group. protein expression TGFB1...
Abstract We retrospectively analyzed the reasons for ineffective pain relief in patients with idiopathic trigeminal neuralgia ( TN ) who had undergone pulsed radiofrequency PRF treatment guided by computed tomography scan. found that intraoperative output voltage and electrical field intensity was significantly higher p < 0.05) group received effective than group. These findings suggest optimizing parameters increasing (electric intensity) may therefore, provide better .
Nephrotoxicity is a known clinical complication of cisplatin that limits the use this potent antitumor drug. Cyclic nucleotide phosphodiesterases (PDEs) play complex roles in physiology and pathology. PDE4, which member PDE family, has four subtypes (PDE4A-PDE4D), PDE4B plays an important role inflammation. Thus, present study, we investigated effect PDE4/PDE4B inhibition on renal function inflammation nephrotoxicity model. In mice, enhanced mRNA protein expression tubules. After treatment...
Diabetic nephropathy (DN) has become the main cause of end-stage renal disease worldwide, but efficacy current therapeutic strategies on DN remains unsatisfactory. Recent research reported involvement metabolic rearrangement in pathological process DN, and all disturbances metabolism, mitochondria serve as key regulatory hubs. In present study, high-resolution mass spectrometry-based nontarget metabolomics was used to uncover characteristics early diabetic kidney with or without inhibition...
// Xiao-Wen Yu 1 , Sensen Lin 2 Hong-Zhi Du Ren-Ping Zhao 3 Shu-Yun Feng Bo-Yang 4 Lu-Yong Zhang Rui-Ming Li 5 Chang-Min Qian Xue-Jun Luo Sheng-Tao Yuan Sun Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing, Key laboratory of Drug Screening, Department Biophysics, University Saarland, Homburg, Germany Laboratory TCM Evaluation Translational Research, Complex Prescription TCM, Tasly Institute, Tianjin Holding Group Co. Ltd., Tianjin,...
Renal fibrosis is a key pathological phenomenon of chronic kidney disease (CKD) contributing to the progressive loss renal function. UK383,367 procollagen C proteinase inhibitor that has been selected as candidate for dermal antiscarring agents, whereas its role in unclear. In present study, was applied CKD mouse model unilateral ureteral obstruction (UUO) and cell lines tubular epithelial cells (mouse proximal cells) fibroblast (NRK-49F challenged by transforming growth factor-β1. vivo,...
Background: Renal tubulointerstitial fibrosis is the key pathological feature in chronic kidney diseases (CKDs) with no satisfactory therapies clinic. Cilomilast a second-generation, selective phosphodiesterase-4 inhibitor, but its role renal CKD remains unclear. Material and Methods: was applied to mice unilateral ureteric obstruction (UUO) fibroblast cells (NRK-49F) stimulated by TGF-β1. inflammation after UUO or TGF-β1 stimulation were examined histology, Western blotting, real-time PCR...
Downregulation of aquaporins (AQPs) in obstructive kidney disease has been well demonstrated with elusive mechanisms. Our previous study indicated that mitochondrial dysfunction played a crucial role this process. However, it is still uncertain how affected the AQPs disease. This investigated mitochondria-derived oxidative stress mediating obstruction-induced downregulation AQPs. After unilateral ureteral obstruction for 7 days, renal superoxide dismutase 2 (SOD2; mitochondria-specific SOD)...