A5100326729- Functional Brain Connectivity Studies
- RNA Research and Splicing
- Neuroscience and Neuropharmacology Research
- Lipid Membrane Structure and Behavior
- Neural dynamics and brain function
- Advanced Neuroimaging Techniques and Applications
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Receptor Mechanisms and Signaling
- Advanced MRI Techniques and Applications
- Photoreceptor and optogenetics research
- Wheat and Barley Genetics and Pathology
- Mesenchymal stem cell research
- Cellular transport and secretion
- ATP Synthase and ATPases Research
- Neurobiology and Insect Physiology Research
- Mental Health Research Topics
- Bipolar Disorder and Treatment
- Genetic Mapping and Diversity in Plants and Animals
- Schizophrenia research and treatment
- Sphingolipid Metabolism and Signaling
- Developmental Biology and Gene Regulation
- Child and Adolescent Psychosocial and Emotional Development
- Lipid metabolism and biosynthesis
- EEG and Brain-Computer Interfaces
Howard Hughes Medical Institute
2025
Stanford University
2025
Sichuan Agricultural University
2021-2024
Hangzhou Normal University
2022-2024
Children's Hospital of Fudan University
2020-2024
Sichuan University
2015-2024
West China Medical Center of Sichuan University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Affiliated Hospital of Hangzhou Normal University
2024
Nantong University
2016-2023
Synapses are organized by trans-synaptic adhesion molecules that coordinate assembly of pre- and postsynaptic specializations, which, in turn, composed scaffolding proteins forming liquid-liquid phase-separated condensates. Presynaptic teneurins mediate excitatory synapse organization binding to latrophilins; however, the mechanism action teneurins, driven extracellular domains evolutionarily derived from bacterial toxins, remains unclear. In this work, we show only intracellular sequence, a...
Oxidative stress contributes to the pathogenesis of diabetic nephropathy (DN). Nuclear factor erythroid 2-related 2 (NRF2) plays a key role in cellular defense against oxidative stress. NRF2 activators have shown promising preventive effects on DN. Sodium butyrate (NaB) is known activator NRF2. However, it unknown whether required for NaB protection Therefore, streptozotocin-induced C57BL/6 Nrf2 knockout and their wild-type mice were treated presence or absence 20 weeks. Diabetic mice, but...
Bone degradation is a serious complication of chronic inflammatory diseases such as septic arthritis, osteomyelitis and infected orthopedic implant failure. At present, effective therapeutic treatments for lipopolysaccharide (LPS)‑induced bone destruction are limited to antibiotics surgical repair in diseases. The present study aimed evaluate the mechanism LPS on osteoclast differentiation activation. RAW264.7 cells were non-induced, or induced by receptor activator nuclear factor-κB (RANK)...
The translocase of the outer mitochondrial membrane (TOM) complex is main entry gate for precursor proteins synthesized on cytosolic ribosomes. Here we report single-particle cryo-electron microscopy (cryo-EM) structure dimeric human TOM core (TOM-CC). Two Tom40 β-barrel proteins, connected by two Tom22 receptor subunits and one phospholipid, form protein-conducting channels. small Tom Tom5, Tom6, Tom7 surround channel have notable configurations. distinct electrostatic features complex,...
Ketamine abuse has been shown to have a deleterious impact on brain function. However, the precise mechanisms of ketamine dependence-induced pathological change remain poorly understood. Although there is evidence for white matter changes in drug abuse, presence abnormalities chronic users not studied. White volumes were measured using vivo diffusion tensor magnetic resonance imaging data 41 ketamine-dependent subjects and 44 drug-free healthy volunteers. associated with use found bilateral...
Previous studies have observed reduced suppression of the default mode network (DMN) during cognitive tasks in schizophrenia, suggesting inefficient DMN is critical for deficits schizophrenia. Cognitive function schizophrenia patients, however, varies from relatively intact to severely impaired. This study, which compared patterns between first-episode patients with (SZ-Imp) and without (SZ-Pre) impaired function, may provide further insight into role dysfunction Independent component...
Schizophrenia and bipolar disorder share some common clinical features are both characterized by aberrant resting-state functional connectivity (FC). However, little is known about the specific of dynamic FC patterns in these two disorders. In this study, we explored differences among schizophrenia patients (n = 66), type I 53) healthy controls comparing temporal variabilities involved brain regions large-scale networks. Compared with controls, patient groups showed significantly increased...
Four types of unconventional intermolecular CO⋯π interactions between carbonyl and pyridyl moieties are identified in the construction two supramolecular frameworks from mononuclear Cu(II) building blocks.
Abstract The diagnosis of schizophrenia is thought to embrace several distinct subgroups. manifold entities in a single clinical patient group increase the variance biological measures, deflate group-level estimates causal factors, and mask presence treatment effects. However, reliable neurobiological boundaries differentiate these subgroups remain elusive. Since cortical thinning well-established feature schizophrenia, we investigated if individuals (patients healthy controls) with similar...
The volume and the electric strength of an excitatory synapse is near linearly correlated with area its postsynaptic density (PSD). Extensive research in past has revealed that PSD assembly directly communicates actin cytoskeleton spine to coordinate activity-induced enlargement as well long-term stable structure maintenance. However, molecular mechanism underlying communication between poorly understood. In this study, we discover vitro reconstituted condensates can promote polymerization...
Abstract We previously reported that RNF148 was involved in the ubiquitination-mediated degradation of CHAC2. However, its molecular mechanism not determined. In this study, we investigated role and progression colorectal cancer (CRC), especially process Our results revealed upregulated most CRC tissues, expression significantly correlated with 3-year overall survival rate clinicopathological parameters patients. Furthermore, served as an independent prognostic biomarker promoted cell...
Abstract As the most prevalent internal modification in eukaryotic RNAs, N6-methyladenosine (m6A) has been discovered to play an essential role cellular proliferation, metabolic homeostasis, embryonic development, etc. With rapid accumulation of research interest m6A, its crucial roles regulations disease development and drug response are gaining more attention. Thus, a database offering such valuable data on m6A-centered regulation is greatly needed; however, no as yet available. Herein,...