A5101533432- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Bipolar Disorder and Treatment
- Schizophrenia research and treatment
- Neural dynamics and brain function
- Mental Health Research Topics
- Child and Adolescent Psychosocial and Emotional Development
- Advanced MRI Techniques and Applications
- EEG and Brain-Computer Interfaces
- Sexual function and dysfunction studies
- Cancer-related gene regulation
- Nuts composition and effects
- Oral Health Pathology and Treatment
- Plant-based Medicinal Research
- Pharmacological Effects and Toxicity Studies
- Recycling and utilization of industrial and municipal waste in materials production
- Genomics and Rare Diseases
- Intracranial Aneurysms: Treatment and Complications
- Neuroendocrine Tumor Research Advances
- Laser Applications in Dentistry and Medicine
- Advanced ceramic materials synthesis
- Microwave Dielectric Ceramics Synthesis
- Epilepsy research and treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Robotics and Automated Systems
China Academy of Engineering Physics
2025
Peking University People's Hospital
2023-2024
Peking University
2023-2024
Shanghai Sixth People's Hospital
2024
Shanghai Jiao Tong University
2024
Ruian People's Hospital
2024
Wenzhou Medical University
2015-2024
Zhejiang University
2018-2023
Hangzhou Medical College
2023
Nanfang Hospital
2023
We aimed to investigate the clinical and genetic features of paroxysmal kinesigenic dyskinesia (PKD) in a large population analyze genotype-phenotype correlation PKD.We analyzed manifestations conducted PRRT2 screening 110 patients with PKD. Clinical data were compared between 91 probands without mutations.Among enrolled participants (45 from 26 families, 65 sporadic cases), 8 mutations detected 20 PKD families (76.9%) 14 cases (21.5%), accounting for 37.4% (34/91) study population. Five...
Previous studies have observed reduced suppression of the default mode network (DMN) during cognitive tasks in schizophrenia, suggesting inefficient DMN is critical for deficits schizophrenia. Cognitive function schizophrenia patients, however, varies from relatively intact to severely impaired. This study, which compared patterns between first-episode patients with (SZ-Imp) and without (SZ-Pre) impaired function, may provide further insight into role dysfunction Independent component...
Abstract The diagnosis of schizophrenia is thought to embrace several distinct subgroups. manifold entities in a single clinical patient group increase the variance biological measures, deflate group-level estimates causal factors, and mask presence treatment effects. However, reliable neurobiological boundaries differentiate these subgroups remain elusive. Since cortical thinning well-established feature schizophrenia, we investigated if individuals (patients healthy controls) with similar...
Schizophrenia and bipolar disorder share some common clinical features are both characterized by aberrant resting-state functional connectivity (FC). However, little is known about the specific of dynamic FC patterns in these two disorders. In this study, we explored differences among schizophrenia patients (n = 66), type I 53) healthy controls comparing temporal variabilities involved brain regions large-scale networks. Compared with controls, patient groups showed significantly increased...
Background: This study compared adaptive resilience among patients with schizophrenia, bipolar disorder, and healthy controls, examined the relationship of to cognitive function. Methods: A sample 81 diagnosed 34 52 controls completed Connor-Davidson Resilience Scale (CD-RISC) tests verbal comprehension, executive functioning, working memory. Paired comparison diagnostic groups on CD-RISC was conducted. Linear regression used identify independent association clinical diagnoses neurocognition...
Psychological resilience is an important personality trait whose decrease associated with many common psychiatric disorders, but the neural mechanisms underlying it remain largely unclear. In this study, we aimed to explore correlates of psychological in healthy adults by investigating its relationship functional brain network flexibility, a fundamental dynamic feature defined switching frequency modular community structures.Resting-state magnetic resonance imaging (fMRI) scans were acquired...
Delusional thinking is one of the hallmark symptoms schizophrenia. However, underlying neural substrate for delusions in schizophrenia remains unknown. In an attempt to further our understanding basis delusions, we explored gray matter deficits and their clinical associations first-episode patients with without delusions.Twenty-four 18 as well 26 healthy controls (HC) underwent assessment whole-brain structural imaging which were acquired a 3.0 T scanner. Voxel-based morphometry was used...
Abstract The effects of cold isostatic pressing (CIP) pressure on the sintering densification, mechanical and insulation performances a 95.5 wt% alumina ceramic are investigated. density sintered increases with increase CIP pressure, tends to level off when is higher than suitable (120 MPa). This attributed effect pore size. fracture strengths green body both linearly densities, which can be explained by weakest‐link assumption that initiates from pores. For ceramics, direct current (DC)...
Purpose To explore the acute effect of betel quid (BQ) use on functional network connectivity by comparing global brain networks and their subsets before immediately after BQ chewing. Materials Methods Resting-state magnetic resonance imaging (fMRI) was performed in 27 healthy male participants just chewing a 3.0T scanner with gradient-echo echo planar sequence. Independent component analysis (ICA) used to determine components that represent brain's spatial aspects connectivity. A paired...
Background: Betel quid (BQ) is a common psychoactive substance worldwide with particularly high usage in many Asian countries. This study aimed to explore the effect of BQ use on functional connectivity by comparing global brain networks and their subset between chewers healthy controls (HCs). Methods: Resting-state magnetic resonance imaging (fMRI) was obtained from 24 betel dependent (BQD) male 27 individuals 3.0T scanner. We used independent component analysis (ICA) determine components...
Introduction: Previous studies have primarily focused on the neuropathological mechanisms of emotional circuit present in bipolar mania and depression. Recent applying resting-state functional magnetic resonance imaging (fMRI) raise possibility examining brain-wide networks abnormality between two oppositional emotion states, thus this study aimed to characterize different architecture represented depression by employing group-independent component analysis (gICA). Materials Methods:...
Background: Aberrant functional and structural connectivity across multiple brain networks have been reported in bipolar disorder (BD). However, most previous studies consider the alterations isolation regardless of their possible integrative relationship. The present study aimed to identify BD by capturing latent nexus multimodal neuroimaging data. Methods: Structural resting-state images were acquired from 83 patients with 94 healthy controls (HCs). Combined univariate methods conducted...
Betel quid (BQ) is one of the most popular addictive substances in world. However, neurophysiological mechanism underlying BQ addiction remains unclear. This study aimed to investigate whether and how chewing would affect brain function framework a dynamic network model. Resting-state functional magnetic resonance imaging scans were collected from 24 male BQ-dependent individuals 26 non-addictive healthy before promptly after BQ. Switching rate, measure temporal stability networks, was...
Background: The active alkaloid in Betel quid is arecoline. Consumption of betel associated with both acute effects and longer-term addictive effects. Despite growing evidence that use linked altered brain function connectivity, the neurobiology this psychoactive substance initial chewing, long-term dependence, not clear. Methods: In observational study, functional magnetic resonance imaging a resting-state was performed 24 male quid-dependent chewers 28 controls prior to promptly after...