A5062894282- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Schizophrenia research and treatment
- Neural dynamics and brain function
- Mental Health Research Topics
- Bipolar Disorder and Treatment
- Neural and Behavioral Psychology Studies
- Genetic Associations and Epidemiology
- Medication Adherence and Compliance
- Child and Adolescent Psychosocial and Emotional Development
- Attention Deficit Hyperactivity Disorder
- Educational Reforms and Innovations
- EEG and Brain-Computer Interfaces
- Electroconvulsive Therapy Studies
- Cardiovascular Syncope and Autonomic Disorders
- Resilience and Mental Health
- Epilepsy research and treatment
- Neuroscience and Music Perception
- Medical Research and Treatments
- Neuroscience and Neuropharmacology Research
- Cell Image Analysis Techniques
- Receptor Mechanisms and Signaling
- Phosphodiesterase function and regulation
- Traditional Chinese Medicine Studies
Central South University
2018-2025
Second Xiangya Hospital of Central South University
2018-2025
Western University
2019-2023
Robarts Clinical Trials
2023
Hunan Institute of Mental Health
2020-2021
Dalhousie University
2021
Lawson Health Research Institute
2021
Background Working memory deficit, a key feature of schizophrenia, is heritable trait shared with unaffected siblings. It can be attributed to dysregulation in transitions from one brain state another. Aims Using network control theory, we evaluate if defective underlie working deficits schizophrenia. Method We examined average and modal controllability the brain's functional connectome 161 patients 37 siblings 96 healthy controls during two-back task. use one-way analysis variance detect...
The heterogeneity of cognitive impairments in schizophrenia has been widely observed. However, reliable boundaries to differentiate the subgroups remain elusive. key challenge for subtyping is applying an integrated and standardized assessment understanding subgroup-specific neurobiological mechanisms. present study endeavors explore identify their morphological features. A total 920 patients 169 healthy controls were recruited. MATRICS Consensus Cognitive Battery was applied assess...
Abstract The diagnosis of schizophrenia is thought to embrace several distinct subgroups. manifold entities in a single clinical patient group increase the variance biological measures, deflate group-level estimates causal factors, and mask presence treatment effects. However, reliable neurobiological boundaries differentiate these subgroups remain elusive. Since cortical thinning well-established feature schizophrenia, we investigated if individuals (patients healthy controls) with similar...
Schizophrenia and bipolar disorder share some common clinical features are both characterized by aberrant resting-state functional connectivity (FC). However, little is known about the specific of dynamic FC patterns in these two disorders. In this study, we explored differences among schizophrenia patients (n = 66), type I 53) healthy controls comparing temporal variabilities involved brain regions large-scale networks. Compared with controls, patient groups showed significantly increased...
Background: This study compared adaptive resilience among patients with schizophrenia, bipolar disorder, and healthy controls, examined the relationship of to cognitive function. Methods: A sample 81 diagnosed 34 52 controls completed Connor-Davidson Resilience Scale (CD-RISC) tests verbal comprehension, executive functioning, working memory. Paired comparison diagnostic groups on CD-RISC was conducted. Linear regression used identify independent association clinical diagnoses neurocognition...
Disorganized thinking is a core feature of acute psychotic episodes that linked to social and vocational functioning. Several lines evidence implicate disrupted cognitive control, excitatory overdrive oxidative stress relating the anterior cingulate cortex as mechanisms conceptual disorganization (CD). We examined 3 candidate mechanistic markers related CD in firstepisode psychosis: glutamate excess, cortical antioxidant (glutathione) status integrity cingulum bundle connects regions...
Abstract Background Recent genetic evidence implicates glutamatergic-receptor variations in schizophrenia. Glutamatergic excess during early life people with schizophrenia may cause excitotoxicity and produce structural deficits the brain. Cortical thickness gyrification are reduced schizophrenia, but only a subgroup of patients exhibits such deficits. We delineate among unaffected siblings study role key glutamate-receptor polymorphisms on these variations. Methods Gaussian Mixture Model...
Language-related symptoms, such as disorganized, impoverished speech and communicative behaviors, are one of the core features schizophrenia. These most strongly correlate with cognitive deficits polygenic risk among various symptom dimensions Nevertheless, unaffected siblings genetic high-risk fail to show consistent in language network (LN), indicating that either (1) has no notable effect on LN and/or (2) compensatory changes opposing direction patients. To answer this question, we...
The advancement of neuroimaging and genetic research has revealed the presence morphological abnormalities numerous risk genes, along with their associations. We aimed to estimate magnetic resonance imaging-derived cortical thickness across multiple brain regions.
The default mode network (DMN) is related to brain functions and its abnormalities were associated with mental disorders' pathophysiology. To further understand the common distinct DMN alterations across disorders, we capitalized on probability tracing method graph theory analyze role of three major disorders. A total 399 participants (156 schizophrenia [SCZ], 90 bipolar disorder [BP], 58 depression [MDD], 95 healthy controls [HC]) completed magnetic resonance imaging (MRI)-scanning,...
The aberration in cortical gyrification seen schizophrenia likely originates the earliest phase of life, as begins utero and reaches its peak infancy. However, emerging observations have indicated a later reduction gyrification, especially early adulthood, may also occur schizophrenia. At present, it is unclear whether baseline has any prognostic importance We address this question longitudinal design patients minimally medicated at inception. About 108 (duration medication = <14 days...
Background: Localized abnormalities in the synchrony of spontaneous neuronal activity, measured with regional homogeneity (ReHo), has been consistently reported patients schizophrenia (SCZ) and their unaffected siblings. To date, little is known about genetic influences affecting activity SCZ. DISC1, a strong susceptible gene for SCZ, implicated excitability synaptic function possibly associated activity. This study aimed to examine effects DISC1 variations on Methods: Resting-state fMRI...
Abstract Schizophrenia and bipolar disorder share some common clinical features are both characterized by aberrant resting-state functional connectivity (FC). However, little is known about the specific of dynamic FC patterns in these two disorders. In this study, we explored differences among schizophrenia patients ( n = 66), type I 53) healthy controls comparing temporal variabilities involved brain regions large-scale networks. Compared with controls, patient groups showed significantly...
Background: The pattern in cortical gyrification is aberrant schizophrenia, which often considered to originate the earliest life as begins utero and reaches its peak early infancy. However, emerging observations have indicated a later-life reduction gyrification, especially adulthood, may also occur schizophrenia. At present, it unclear whether this has any prognostic importance We address question longitudinal design patients minimally medicated at inception.Methods: 108 untreated 106...
Major psychiatric disorders (MPDs) are delineated by distinct clinical features. However, overlapping symptoms and transdiagnostic effectiveness of medications have challenged the traditional diagnostic categorisation. We investigate if there shared illness-specific disruptions in regional functional efficiency (RFE) brain across these disorders.
<title>Abstract</title> Working memory (WM) deficit is a prominent and common cognitive impairment in major psychiatric disorders (MPDs). Altered control of brain states transitions may underlie the neural basis WM deficit. Brain controllability derived from Network Control Theory provides mathematical framework to study how external signals affect network dynamics influence transition desired states. We investigate if shared illness-specific alterations deficits MPDs. examined fMRI data...
The structural integrity of the anterior cingulum has been repeatedly observed to be abnormal in psychosis. Cingulum tract carries fibers that connect medial prefrontal structures with precuneus, thus serving as major pathway within default mode network (DMN), critical for self-related processing. Persistent disorganization (or formal thought disorder) is largely considered a language-related dysfunction, though neural basis acute yet unknown. We studied bilateral identify if fractional...
The clinical diagnosis of schizophrenia is suspected to include several distinct subgroups patients, but reliable neurobiological boundaries differentiate the remain elusive. These unknown increase variance biological measures within clinically identified patient group, deflating group-level estimates causal factors and treatment effects. Prior studies seeking homogeneous based on brain-based have not found consistent solutions. A major limitation in prior assumption that healthy controls...
Abstract Background The Medication Adherence Rating Scale (MARS) is a rapid, non-intrusive way of measuring adherence to medication in order improve management patients with schizophrenia. current study evaluated the reliability Chinese (Mandarin) version MARS and explored clinical demographic correlates large sample recurrent schizophrenia China. Methods 1198 were recruited from 37 different hospitals 17 provinces/municipalities China (MARS), Clinical Global Impression-Severity illness...