A5015325600- Functional Brain Connectivity Studies
- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Acupuncture Treatment Research Studies
- Alzheimer's disease research and treatments
- Neural dynamics and brain function
- Traditional Chinese Medicine Studies
- Radiation Detection and Scintillator Technologies
- Neuroscience and Neuropharmacology Research
- Pain Management and Placebo Effect
- Neural Networks and Applications
- Stress Responses and Cortisol
- Nuclear Physics and Applications
- Dementia and Cognitive Impairment Research
- Systemic Lupus Erythematosus Research
- Healthcare and Venom Research
- Complementary and Alternative Medicine Studies
- Schizophrenia research and treatment
- Neurological Disease Mechanisms and Treatments
- Tryptophan and brain disorders
- Radiomics and Machine Learning in Medical Imaging
- Atomic and Subatomic Physics Research
- Treatment of Major Depression
- Diet and metabolism studies
Chinese Academy of Sciences
2016-2025
Institute of High Energy Physics
2016-2025
University of Chinese Academy of Sciences
2008-2024
Center for Excellence in Brain Science and Intelligence Technology
2017-2022
Wuhan Institute of Physics and Mathematics
2022
State Key Laboratory of Magnetism
2022
University of Science and Technology of China
2022
Energy Research Institute
2022
Key Laboratory of Nuclear Radiation and Nuclear Energy Technology
2014-2021
Ministry of Education of the People's Republic of China
2021
Abstract This study constructs a rat brain T 2 ‐weighted magnetic resonance imaging template including olfactory bulb and compatible digital atlas. The atlas contains 624 carefully delineated structures based on the newest (2005) edition of by Paxinos Watson. An automated procedure, as an SPM toolbox, was introduced for spatially normalizing individual brains, conducting statistical analysis visually localizing results in Atlas coordinate space. template/atlas procedure were evaluated using...
We aim to clarify the mechanisms of acupuncture in treating mild cognitive impairment (MCI) and Alzheimer disease (AD) by using functional magnetic resonance imaging (fMRI). Thirty-six right-handed subjects (8 MCI patients, 14 AD healthy elders) participated this study. Clinical neuropsychological examinations were performed on all subjects. MRI data acquisition was a SIEMENS verio 3-Tesla scanner. The fMRI study used single block experimental design. first acquired baseline resting state...
Previous studies have observed reduced suppression of the default mode network (DMN) during cognitive tasks in schizophrenia, suggesting inefficient DMN is critical for deficits schizophrenia. Cognitive function schizophrenia patients, however, varies from relatively intact to severely impaired. This study, which compared patterns between first-episode patients with (SZ-Imp) and without (SZ-Pre) impaired function, may provide further insight into role dysfunction Independent component...
Brain capillaries are crucial for cognitive functions by supplying oxygen and other nutrients to removing metabolic wastes from the brain. Recent studies have demonstrated that constriction of brain is triggered beta-amyloid (Aβ) oligomers via endothelin-1 (ET1)-mediated action on ET1 receptor A (ETRA), potentially exacerbating Aβ plaque deposition, primary pathophysiology Alzheimer's disease (AD). However, direct evidence still lacking whether changes in causally involved AD. Using APP/PS1...
Objectives: Fractional anisotropy (FA) via diffusion tensor imaging (DTI) can quantify the white matter integrity. Exposure to addictive drugs, such as alcohol, cocaine, methamphetamine, marijuana, and nicotine has been shown alter FA. White abnormalities have shown, but it remains unclear whether FA is altered in heroin dependence. Methods: Utilizing DTI, we investigated difference between heroin-dependent control subjects by a voxel-based strategy. The values of identified regions were...
Background Obsessive-compulsive disorder (OCD) is a mental illness characterized by the loss of control. Because cingulate cortex believed to be important in executive functions, such as inhibition, we used functional magnetic resonance imaging (fMRI) techniques examine whether and how activity connectivity (FC) were altered drug-naïve OCD patients. Methods Twenty-three medication-naïve patients 23 well-matched healthy controls received fMRI scans resting state. Functional connectivities...
<h3>Background:</h3> Abnormalities in the corpus callosum have long been implicated schizophrenia. Previous diffusion tensor imaging (DTI) studies patients with different durations of schizophrenia yielded inconsistent results. By comparing schizophrenia, we investigated if white matter abnormalities emerge at an early stage illness or result from pathological progression. <h3>Methods:</h3> We recruited first-episode chronic and age-, sex-and handedness-matched healthy controls. used 2 DTI...
It is generally accepted that cognitive processes, such as learning and memory, are affected in depression. The present study used a rat model of depression, chronic unpredictable mild stress (CUMS), to determine whether hippocampal volume neurochemical changes were involved memory alterations. A further aim was these effects could be ameliorated by escitalopram treatment, assessed with the non-invasive techniques structural magnetic resonance imaging (MRI) spectroscopy (MRS). Our results...
Abstract Background White matter abnormalities can cause network dysfunction that underlies major depressive disorder (MDD). Diffusion tensor imaging (DTI) is used to examine the neural connectivity and integrity of white matter. Previous studies have implicated frontolimbic networks in pathophysiology MDD. Approximately 30% MDD patients demonstrate treatment-resistant depression (TRD). However, neurobiology TRD remains unclear. Methods We a voxel-based analysis method analyze DTI data young...
Background Due to a lack of evidence, there is no consistent age onset define early (EO) versus later (LO) major depressive disorder (MDD). Fractional anisotropy (FA), derived from diffusion tensor imaging (DTI), has been widely used study neuropsychiatric disorders by providing information about the brain circuitry, abnormalities which might facilitate delineation EO LO MDD. Method In this study, 61 pairs untreated, non-elderly, first-episode MDD patients and healthy controls (HCs) aged...
Purpose PET (positron emission tomography) imaging researches of functional metabolism using fluorodeoxyglucose (18F-FDG) animal brain are important in neuroscience studies. FDG-PET studies often performed on groups rats, so it is desirable to establish an objective voxel-based statistical methodology for group data analysis. Material and Methods This study establishes a parametric mapping (SPM) toolbox (plug-ins) named spmratIHEP voxel-wise analysis images rat brain, which template...
Acute ischemic stroke (AIS) is a significant brain disease with high mortality and disability rate. Additional therapies for AIS are urgently needed, neuroplasticity mechanisms by agents expected to be neuroprotective AIS. As major active component of Salvia miltiorrhiza, salvianolic acid A (SAA) has shown potential preventing cardiovascular diseases. However, there no evidence the long-term effect SAA on injury or its mechanism. Therefore, using rats mice, we systematically investigated...
Auditory verbal hallucinations (AVHs) represent one of the most intriguing phenomena in schizophrenia, however, brain abnormalities underlying AVHs remain unclear. The present study examined association between cortical thickness and first-episode schizophrenia. High-resolution MR images were obtained 49 schizophrenia (FES) patients 50 well-matched healthy controls (HCs). Among FES patients, 18 suffered persistent ("auditory hallucination" AH group), 31 never experienced ("no NH group)....
The present study investigated alteration of brain resting-state activity induced by antidepressant treatment and attempted to investigate whether efficacy can be predicted at an early stage pharmacological treatment.Forty-eight first-episode medication-free patients diagnosed with major depression received escitalopram. Resting-state functional magnetic resonance imaging was administered prior treatment, 5 h after the first dose, during course (week 4) endpoint 8). evaluated in 8-week...