A5101197079- Functional Brain Connectivity Studies
- Posttraumatic Stress Disorder Research
- Mass Spectrometry Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Advanced Proteomics Techniques and Applications
- Traumatic Brain Injury Research
- Advanced MRI Techniques and Applications
- Transcranial Magnetic Stimulation Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Sleep and Wakefulness Research
- Stress Responses and Cortisol
- Neural dynamics and brain function
- Sleep and related disorders
- Viral Infectious Diseases and Gene Expression in Insects
- Monoclonal and Polyclonal Antibodies Research
- Grief, Bereavement, and Mental Health
- Neuroendocrine regulation and behavior
- Child Development and Digital Technology
- Treatment of Major Depression
- Acute Ischemic Stroke Management
- Metabolism, Diabetes, and Cancer
- Digital Mental Health Interventions
- Protein purification and stability
- RNA and protein synthesis mechanisms
- Olfactory and Sensory Function Studies
Clinical Trial Investigators
2024
Central South University
2011-2023
Hangzhou Seventh Peoples Hospital
2017-2023
Second Xiangya Hospital of Central South University
2011-2023
Zhejiang University
2007-2022
Sichuan University
2020
West China Hospital of Sichuan University
2020
Momenta Pharmaceuticals (United States)
2007-2016
Shanghai Jiao Tong University
2015
Shenyang 242 Hospital
2012
Is there a common structural and functional cortical architecture that can be quantitatively encoded precisely reproduced across individuals populations? This question is still largely unanswered due to the vast complexity, variability, nonlinearity of cerebral cortex. Here, we hypothesize effectively represented by group-wise consistent fiber connections take novel data-driven approach explore architecture. We report dense map 358 landmarks, named Dense Individualized Common...
Purposes Recent neuroimaging studies have shown that people with Internet gaming disorder (IGD) structural and functional abnormalities in specific brain areas connections. However, little is known about the alterations of interhemispheric resting-state connectivity (rsFC) participants IGD. In present study, we used a newly developed voxel-mirrored homotopic (VMHC) method to investigate rsFC whole Methods We compared between 17 IGD 24 healthy controls, group-matched on age, gender, education...
Host cell protein (HCP) impurities are generated by the host organism during production of therapeutic recombinant proteins, and difficult to remove completely. Though commonly present in small quantities, if levels not controlled, HCPs can potentially reduce drug efficacy cause adverse patient reactions. A high resolution approach for thorough HCP characterization monoclonal antibodies is presented herein. In this method, antibody samples first depleted via affinity enrichment (e.g.,...
Abstract Objectives Functional neuroimaging studies have shown that amputees altered cortical reorganization and functional connectivity (FC). This study aimed to investigate whether patients with phantom limb pain (PLP) PLP‐free lower exhibit changes in corresponding primary motor area/somatosensory cortex (M1/S1) supplementary area (SMA) network FC. The association between magnetic resonance imaging (fMRI) clinical parameters is also explored. Methods A total of 10 PLP were matched healthy...
Losing an only child is a devastating life event that parent can experience and may lead to post-traumatic stress disorder (PTSD). Social support could buffer against the negative influence of this trauma, but neural mechanism underlying alleviation effect remains poorly understood. In study, voxel-based morphometry was conducted on brain MRI 220 Han Chinese adults who had lost their child. We performed multiple regression analysis investigate associations between social scores - along with...
To compare the difference between acupuncture and estazolam on arousal state in patients of primary insomnia, to explore its nerve electrophysiology mechanism.Sixty-four insomnia were randomized into an group (32 cases) a medication cases). After 3 excluded, 31 cases 30 included. Patients treated with at Sishencong (EX-HN 1), Anmian (Extra), Shenmen (HT 7), Sanyinjiao (SP 6), Zhaohai (KI Shenmai (BL 62) as main acupoints, combined supporting once day, five times per week, continuously for 4...
The stress-related gene FKBP5 has been related to dysregulated glucocorticoid receptor (GR) signaling, showing increased GR sensitivity in trauma-exposed subjects with post-traumatic stress disorder (PTSD) but not those without PTSD. However, the neural mechanism underlying effects of remains poorly understood. Two hundred and thirty-seven Han Chinese adults who had lost their only child were included. Four single nucleotide polymorphisms (rs3800373, rs9296158, rs1360780, rs9470080)...
A novel microfluidic chip based Edman degradation system is developed, in which can be carried out with peptide at a subfemtomole level; combined MALDI-TOF-MS detection, the identification specificity of gel-separated protein low abundance has been drastically improved.
The neural substrates of posttraumatic stress disorder (PTSD) are still not fully elucidated. Hence, this study is to explore topological alterations the default mode network (DMN) in victims with PTSD after a magnitude 8.0 earthquake using resting-state functional magnetic resonance imaging (rs-fMRI). This was approved by local ethical review board, and all participants signed written informed consent. Sixty-two from 2008 Sichuan 62 matched exposed controls underwent rs-fMRI. diagnosed...
Protein higher order structure (HOS) describes the three-dimensional folding arrangement of a given protein and plays critical roles in structure/function relationships. As such, it is key product quality attribute that monitored during biopharmaceutical development. Covalent labeling surface residues, combined with mass spectrometry analysis, has increasingly played an important role characterizing localized HOS. Since label can potentially induce conformation changes, protocols generally...
The aim of this study was to identify regions with altered degrees centrality (DC) and changes in their functional connectivity (FC) first-episode drug-naïve major depressive disorder (FEDN-MDD) patients using resting-state magnetic resonance imaging (fMRI). included 74 FEDN-MDD who met the criteria 41 healthy controls (HCs). All had undergone fMRI scanning resting condition. To evaluate differences between HCs, we first compared DC 2 groups. most significant were then taken as seeds, FC...
Introduction The aim of this study was to investigate the neurofunctional alterations in both acute and chronic post‐traumatic stress disorder ( PTSD ) resulting from same experience. Methods Brain responses emotional trauma‐related neutral pictures with a symptom provocation task were measured using functional magnetic resonance imaging (f MRI ). Twenty‐four patients mining accident 14 controls exposed without two months post‐trauma recruited. In follow‐up 20 also recruited after 24...
This paper expands the application of newly developed highly sensitive microfluidic chip-based Edman degradation system. Comparison between MS/MS spectra a native peptide and its N-terminus truncated counterpart after carrying out one cycle in chip can not only provide N-terminal residue information, but also facilitate identification different series fragment ions. Manual sequencing is more feasible rapid using this method as demonstrated with three examples including neuropeptide....
Objective To investigate the efficacy of internet-based digital delivery cognitive behavioral therapy for patients with insomnia (dCBT-I). Methods 148 who met DSM-Ⅴ criteria disorder were randomized into dCBT-I group (n=74) received CBT on line, and control face to face. Pittsburgh Sleep Quality Index (PSQI), Patient Health Questionnaire-9 (PHQ-9) Generalized Anxiety Disorder-7 (GAD-7) evaluated in both groups at baseline, weeks 2, 4, 6 8. Differences between two compared by repeated...