A5014842469- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Traumatic Brain Injury Research
- Aging and Gerontology Research
- Advanced Neuroimaging Techniques and Applications
- Antioxidant Activity and Oxidative Stress
- Neural and Behavioral Psychology Studies
- Health disparities and outcomes
- Frailty in Older Adults
- Visual perception and processing mechanisms
- Injury Epidemiology and Prevention
- Advanced MRI Techniques and Applications
- Schizophrenia research and treatment
- Intergenerational Family Dynamics and Caregiving
- Neural dynamics and brain function
- Health and Well-being Studies
- Cardiac Arrest and Resuscitation
- Cognitive Abilities and Testing
- Sensory Analysis and Statistical Methods
- EEG and Brain-Computer Interfaces
- Traumatic Brain Injury and Neurovascular Disturbances
- Memory and Neural Mechanisms
- Health, Environment, Cognitive Aging
- Cognitive Functions and Memory
- Blood Pressure and Hypertension Studies
University of Georgia
2014-2023
Franklin College
2018
Center for Translational Research in Neuroimaging and Data Science
2013
Institute of Psychology
2012
University of Arkansas for Medical Sciences
2004
University of South Alabama
2004
Washington University in St. Louis
1994
University of Mississippi
1992
University of Virginia Medical Center
1979
Virginia Department of Health
1979
Objectives: Caring for a sick or disabled relative has been linked to compromised caregiver health, and risk factors negative outcomes have studied extensively, but little attention given care recipient health as potentially harmful behavior by informal caregivers. This article explores such factors. Design: Structured interviews from baseline assessment of the Family Relationships in Late Life Study. Setting: Three U.S. communities. Participants: Referred, volunteer sample 265...
Oxidative stress is involved in age-related cognitive decline. The dietary antioxidants, carotenoids, tocopherols, and vitamin A may play a role the prevention or delay In this study, sera were obtained from 78 octogenarians 220 centenarians Georgia Centenarian Study. Brain tissues 47 centenarian decedents. Samples analyzed for α-tocopherol, retinol using HPLC. Analyte concentrations compared with tests designed to evaluate global cognition, dementia, depression domains (memory, processing...
Is there a common structural and functional cortical architecture that can be quantitatively encoded precisely reproduced across individuals populations? This question is still largely unanswered due to the vast complexity, variability, nonlinearity of cerebral cortex. Here, we hypothesize effectively represented by group-wise consistent fiber connections take novel data-driven approach explore architecture. We report dense map 358 landmarks, named Dense Individualized Common...
Convoluted cortical folding and neuronal wiring are 2 prominent attributes of the mammalian brain. However, macroscale intrinsic relationship between these general cross-species attributes, as well underlying principles that sculpt architecture cerebral cortex, remains unclear. Here, we show axonal fibers connected to gyri significantly denser than those sulci. In human, chimpanzee, macaque brains, a dominant fraction were found be gyri. This finding has been replicated in range brains via...
This research examined longitudinal associations between caregiving stressors, caregiver depression, and quality of care. Informal caregivers elderly care recipients were interviewed at baseline (N = 310) again one year later 213). Hierarchical regression analyses indicated that increases in stressors (i.e., physical health symptoms, activity restriction, recipient controlling manipulative behavior) related to increased depression. In turn, depression decreased respectful behavior predicted...
Background: High levels of xanthophyll carotenoids lutein (L) and zeaxanthin (Z) in the central nervous system have been previously correlated with improved cognitive function community-dwelling older adults. In this study, we tested effects supplementing L Z on men women a range baseline abilities. Objective: The purpose study was to determine whether or not supplementation L+Z could improve community-dwelling, Design: Double-masked, randomized, placebo-controlled trial. A total 62 adults...
Abstract Objectives: The present study constitutes the first randomized controlled trial to investigate relation of lutein (L) and zeaxanthin (Z) brain function using functional magnetic resonance imaging (fMRI). It was hypothesized that L Z supplementation in older adults would enhance neural efficiency (i.e., reduce activation) cognitive performance on a verbal learning task relative placebo. Methods: A total 44 community-dwelling (mean age=72 years) were randomly assigned receive either...
Mild cognitive impairment (MCI) has received increasing attention not only because of its potential as a precursor for Alzheimer's disease but also predictor conversion to other neurodegenerative diseases. Although MCI been defined clinically, accurate and efficient diagnosis is still challenging. neuroimaging techniques hold promise, compared commonly used biomarkers including amyloid plaques, tau protein levels brain tissue atrophy, are less well validated. In this article, we propose...
This study tested the ecological validity of four Delis-Kaplan Executive Function System (D-KEFS) tests by examining how well performance on D-KEFS measures predicted observed daily functioning in community-dwelling older adults. Older adults ages 65 to 92 years completed requiring planning and cognitive fluency. The combined accounted for approximately 26% variance functional ability, when controlling education depression, thus supporting (Pearson r = .66). However, a multiple regression...
While it is understood that longevity and health are influenced by complex interactions among biological, psychological, sociological factors, there a general lack of understanding on how psychosocial factors impact longevity, health, quality life the oldest old. One reasons for this paradox amount funded research aging in US significantly larger biomedical compared to domains. The goals paper highlight recent data demonstrate four pertinent domains old supplement recommendations 2001 NIA...
The goals of this article are to (a) establish the concurrent and clinical validity Global Deterioration scale in assessing cognitive functions stages dementia among centenarians, (b) identify prevalence all-cause representative samples (c) demonstrate how variations sample demographic characteristics could significantly affect estimates prevalence. A quarter 244 centenarians a population-based had no objective evidence memory deficits. Another showed signs transient confusion, about half...
Abstract Objectives: It is well known that the carotenoids lutein (L) and zeaxanthin (Z) improve eye health an accumulating evidence base suggests cognitive benefits as well. The present study investigated underlying neural mechanisms using functional magnetic resonance imaging (fMRI). was hypothesized lower L Z concentrations would be associated with neurobiological inefficiency (i.e., increased activation) during performance. Methods: Forty-three community-dwelling older adults (mean...
ABSTRACT We present normative data from a large population-based sample of centenarians for several brief, global neurocognitive tasks amenable frail elders. Comparative octogenarians are included. A total 244 and 80 Phase III the Georgia Centenarian Study were administered Mini-Mental Status Examination, Severe Impairment Battery, Behavioral Dyscontrol Scale. Centenarians (age 98–107) stratified into three age cohorts (98–99, 100–101, 102–107), two 5- year (80–84, 85–89). Highly significant...
Older adults (OAs) with mild cognitive impairment (MCI) are traditionally thought to have preservation of activities daily living (ADLs). However, recent evidence suggests OAs MCI may difficulty completing ADLs and specifically instrumental (IADLs). The frequently evaluated through self- or collateral report questionnaires, while performance-based measures infrequently utilized, despite the decreased bias increased accuracy sensitivity associated these instruments. This investigation...