A5044992207- Viral-associated cancers and disorders
- RNA modifications and cancer
- Inflammatory Bowel Disease
- MicroRNA in disease regulation
- Cytomegalovirus and herpesvirus research
- Advances in Cucurbitaceae Research
- RNA Interference and Gene Delivery
- Intestinal and Peritoneal Adhesions
- Lymphoma Diagnosis and Treatment
- Hernia repair and management
- Wound Healing and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Microbial bioremediation and biosurfactants
- Phytochemical compounds biological activities
- Bioactive Compounds and Antitumor Agents
- Eosinophilic Esophagitis
- Animal Virus Infections Studies
- Mass Spectrometry Techniques and Applications
- IL-33, ST2, and ILC Pathways
- Genomics and Chromatin Dynamics
- Beetle Biology and Toxicology Studies
- Hydrogen's biological and therapeutic effects
- Virus-based gene therapy research
- Microbial Metabolic Engineering and Bioproduction
- Liver Disease and Transplantation
Ruijin Hospital
2024
Shanghai Jiao Tong University
2024
Shanghai Institute of Hematology
2024
North China Electric Power University
2023-2024
Shanghai First Maternity and Infant Hospital
2019-2023
Shanghai East Hospital
2016-2022
Ocean University of China
2011-2022
Anhui Medical University
2019-2022
Hefei University
2021
Qingdao National Laboratory for Marine Science and Technology
2018-2019
Abstract MicroRNAs (miRNAs) loss-of-function phenotypes are mainly induced by chemically modified antisense oligonucleotides. Here we develop an alternative inhibitor for miRNAs, termed ‘small RNA zipper’. It is designed to connect miRNA molecules end end, forming a DNA–RNA duplex through complementary interaction with high affinity, specificity and stability. Two miR-221 miR-17, tested in human breast cancer cell lines, demonstrating the 70∼90% knockdown of levels 30–50 nM small zippers....
This is the first and largest prospective, multicenter, active, population-based surveillance study of epidemiology Mycoplasma pneumoniae among outpatient children with mild respiratory tract infections (RTIs) during COVID-19 pandemic. Nationwide measures like strict face mask wearing restrictions on population movement implemented to prevent spread might also effectively M. .
Cancer is considered to have an adverse influence on health around the world. Chitosan, a linear polysaccharide that contains copolymers of β-1-4 linked d-glucosamine and N-acetyl-d-glucosamine units, has been widely used in field biomedicine, owing its nontoxicity, biocompatibility, biodegradability, hemocompatibility. This study was aimed at preparing chitosan oligosaccharides (COS) examining ability suppressing lung cancer vitro vivo. Human non-small-cell A549 cells model C57BL/6 mice...
Acute myeloid leukemia (AML) is recognized as an aggressive cancer that characterized by significant metabolic reprogramming. Here, we applied spatial metabolomics to achieve high-throughput, in situ identification of metabolites within the liver metastases AML mice. Alterations at metabolite and protein levels were further mapped out validated integrating untargeted proteomics. This study showed a downregulation arginine's contribution polyamine biosynthesis urea cycle, coupled with...
The plant homeodomain (PHD) finger-containing proteins have been implicated in many human diseases including cancer. In this study, we found that PHF14, a newly identified PHD finger protein, is highly expressed lung high expression level of PHF14 was associated with adenocarcinoma and poor survival cancer patients. Knocking down suppressed cell growth carcinogenesis, while over-expressing promoted proliferation. During division, directly bound to co-localized KIF4A (a nuclear motor protein...
Background: Genetic classification of breast cancer based on the coding mRNA suggests evolution distinct subtypes.Whether non-coding genome is altered concordantly with and mechanism by which cell cycle directly controls poorly understood.Methods: Herein, miRNA signature maintained endogenous cyclin D1 in human cells was defined.In order to determine clinical significance D1-mediated signature, we defined a expression superset from 459 samples.We compared subtypes.Results: Hierarchical...
ABSTRACT The genus Rhodococcus is known for its ability to degrade various xenobiotic compounds. sp. strain P14 isolated from crude oil-contaminated sediments can mineral oil and polycyclic aromatic hydrocarbons (PAHs). draft genome sequence of was obtained using Solexa technology, which provided an invaluable genetic background further investigation the
// Lu Dai 1, 2, 4, * , Lihua Bai Zhen Lin 6 Jing Qiao 5 Liang Yang 7 Erik K. Flemington Jovanny Zabaleta 8 Zhiqiang Qin 3 1 Department of Oncology, East Hospital, Tongji University School Medicine, Shanghai, 200120, China 2 Research Center for Translational Medicine and Key Laboratory Arrhythmias, Departments Microbiology/Immunology/Parasitology, Louisiana State Health Sciences Center, Cancer New Orleans, LA, 70112, USA 4 Pediatrics, Pathology, Tulane Singapore Centre Environmental Life...
Collectively, viruses are the principal cause of cancers arising in patients with immune dysfunction, including human immunodeficiency virus (HIV)-positive patients. Kaposi sarcoma (KS) etiologically linked to sarcoma-associated herpesvirus (KSHV) continues be most common AIDS-associated tumor. The involvement oral cavity represents one clinical manifestations this HIV infection incurs an increased risk among individuals periodontal diseases and carriage a variety pathogenic bacteria....
Abstract Hippocampal neural stem cell (NSC) proliferation is known to decline with age, which closely linked learning and memory impairments. In the current study, we found that expression level of miR‐181a‐5p was decreased in hippocampal NSCs aged mice exogenous overexpression promoted NSC without affecting differentiation into neurons astrocytes. The mechanistic study revealed phosphatase tensin homolog (PTEN), a negative regulator AKT signaling pathway, target knockdown PTEN could rescue...