A5101802430- Enzyme Production and Characterization
- Studies on Chitinases and Chitosanases
- Protein Hydrolysis and Bioactive Peptides
- Circular RNAs in diseases
- Biopolymer Synthesis and Applications
- MicroRNA in disease regulation
- Beetle Biology and Toxicology Studies
- Phytochemical compounds biological activities
- Nanocomposite Films for Food Packaging
- Protease and Inhibitor Mechanisms
- Biofuel production and bioconversion
- Cancer-related molecular mechanisms research
- Polymer Surface Interaction Studies
- Osteoarthritis Treatment and Mechanisms
- Polysaccharides and Plant Cell Walls
- Seaweed-derived Bioactive Compounds
- Galectins and Cancer Biology
- Silk-based biomaterials and applications
- Extracellular vesicles in disease
- Natural Compounds in Disease Treatment
- Bone Tissue Engineering Materials
- Nanoparticle-Based Drug Delivery
- Angiogenesis and VEGF in Cancer
- Proteoglycans and glycosaminoglycans research
- Vitamin D Research Studies
Wuyi University
2024
Ocean University of China
2012-2024
North Sichuan Medical University
2021-2023
Nanjing Medical University
2020-2023
Jiangsu Province Hospital
2020-2023
Nanchong Central Hospital
2023
Qingdao National Laboratory for Marine Science and Technology
2018
Affiliated Hospital of Qingdao University
2005
Qingdao University
2005
Increasing evidence indicates that lymphocyte cytosolic protein 1 (LCP1) overexpression contributes to tumor progression; however, its role in osteosarcoma (OS) remains unclear. We aimed investigate the potential effect of LCP1 OS and underlying mechanisms. first demonstrated is upregulated cell lines tissues. Then, we found aberrant expression could induce proliferation metastasis cells vitro vivo by destabilizing neuregulin receptor degradation protein-1 (Nrdp1) subsequently activating...
The aim of the present study was to evaluate anticancer effects chitooligosaccharides (COS) and N-acetyl-D-glucosamine (NAG), as well investigate possible mechanisms involved. MTT assay flow cytometry were used effect various concentrations COS NAG on proliferation differentiation peripheral blood mononuclear cells (PBMCs). In addition, sarcoma 180 transplanted into mice establish a tumor model. administered by gavage doses. inhibition rate, thymus spleen indexes, natural killer (NK) cell...
Chitosanase is able to specifically cleave β-1,4-glycosidic bond linkages in chitosan produce a chito-oligomer product, which has found variety of applications many areas, including functional food and cancer therapy. Although several structures for chitosanase have been determined, the substrate-binding mechanism this enzyme not fully elucidated because lack high-resolution structure chitosanase-substrate complex. In present study we show crystal novel OU01 from Microbacterium sp. complex...
It is still a major challenge to remove tumor cells and fill bone defects after resection. Combined with the 3D printing technology, composite bioceramics scaffolds were fabricated interconnected porous magnesium-doped wollastonite (CSi-Mg) as architecture nano-hydroxyapatite (n-HA) surface. The influence of manufacturing process on n-HA layer thickness degradation performance, biological performance anti-tumor investigated. surface could effectively retard rate CSi-Mg maintain high...
Short peptides have become the focus of recent research due to their variable bioactivities, good digestibility and wide existences in food-derived protein hydrolysates. However, high complexity samples, identifying short still remains a challenge. In this work, tool, named PeposX-Exhaust, was developed for peptide identification. Through validation with known peptides, PeposX-Exhaust identified all submitted spectra accuracy rate reached 75.36%, adjusted further 98.55% when top 5 candidates...
Postmenopausal osteoporosis has seriously affected the life quality of elderly women. A natural polymer, chitin, obtained from shells crab and shrimp, been widely used in biomedical field owing to its nontoxicity, biocompatibility, biodegradability. In this study, N-acetyl-d-glucosamine (NAG) was prepared liquefied chitin. The protective activities NAG postmenopausal were evaluated on Sprague Dawley rats osteoblast-based models. Results showed that oral administration boosted trabecular bone...
Osteosarcoma (OS) is a malignant tumor originating from mesenchymal stem cells, and has an extremely high fatality rate ability to metastasize. Although mounting evidence suggests that miR-769-5p strongly associated with the progression poor prognosis of various tumors, exact role in OS still unclear. Therefore, this study aimed explore relationship between OS, its underlying mechanism action.miR-769-5p expression was analyzed GSE28423 GEO database measured clinical specimens cell lines. The...
The protective effects of chitosan oligosaccharide (COS), d-glucosamine (GlcNH2) and N-acetyl-d-glucosamine (GlcNAc) on carbon tetrachloride (CCl4)-induced hepatotoxicity the possible mechanisms that involved were investigated in male ICR mice. CCl4 (20 mg/kg body weight, i.p.) administration induced marked increase serum AST ALT activities, primed liver lipid peroxidation, depleted sulfhydryl content, impaired total antioxidant capabilities genotoxicity 24 h after administration....
Four isonitrogenous (gross protein content 30%) and isoenergetic energy 15 kJ/g) diets were formulated to investigate the effects of inclusion plant proteins on hybrid tilapia (Oreochromis niloticus×Oreochromis aureus). The tested soybean meal (SBM), rapeseed (RSM), cottonseed (CSM), peanut (PNM). In each diet, 30% was supplied by fish meal, rest tested. Each diet randomly fed three groups for 8 wk in a recirculating freshwater system. results showed that best performance terms final weight,...
Carboxymethyl-chitosan, a water-soluble derivative of chitosan, has emerged as promising candidate for biomedical applications due to its excellent water solubility, biodegradation, biocompatibility, hydrating, antimicrobial, and nontoxicity. In this paper, the antitumor proliferation metastasis was studied in vitro vivo evaluate biocompatibility carboxymethyl-chitosan biomaterials drug delivery. The results showed that could significantly reduce clone formation tumor migration human cancer...