A5100360401- Extracellular vesicles in disease
- Mesenchymal stem cell research
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Dermatologic Treatments and Research
- Wound Healing and Treatments
- Epigenetics and DNA Methylation
- Glioma Diagnosis and Treatment
- Tissue Engineering and Regenerative Medicine
- Cancer, Lipids, and Metabolism
- Breast Cancer Treatment Studies
- Estrogen and related hormone effects
- RNA Interference and Gene Delivery
- Acne and Rosacea Treatments and Effects
- Skin Protection and Aging
- Cancer Research and Treatments
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Nanoplatforms for cancer theranostics
Huazhong University of Science and Technology
2013-2025
Tongji Hospital
2011-2025
Fudan University Shanghai Cancer Center
2019-2025
Sun Yat-sen University
2012-2025
Third Affiliated Hospital of Sun Yat-sen University
2020-2025
Northeastern University
2023-2025
Shanghai Medical College of Fudan University
2025
Beijing National Laboratory for Molecular Sciences
2025
Peking University
2004-2025
Chinese PLA General Hospital
2017-2025
The majority of breast cancer patients die metastasis rather than primary tumors, whereas the molecular mechanisms orchestrating remains poorly understood. Long noncoding RNAs (lncRNA) have been shown to regulate occurrence and progression. However, lncRNAs that drive in their underlying are still largely unknown.lncRNAs highly expressed metastatic lymph nodes were identified by microarray. Survival analysis made Kaplan-Meier method. Cell proliferation, migration, invasion assay was...
Due to the heterogeneity of breast cancer, its early accurate diagnosis remains a challenge. Exosomes carry abundant genetic materials and proteins are ideal biomarkers for cancer detection. Herein, ratiometric surface-enhanced Raman scattering (SERS) biosensor exosome detection was constructed using regularly arranged Au@Ag nanoparticles/graphene oxide (Au@Ag NPs/GO) substrate with 4-nitrothiophenol (4-NTP) molecules as an internal standard. Aptamers two overexpressed (epithelial cell...
Delayed wound healing brings additional physical, mental, and financial burdens. Microneedles (MNs) are a novel dressing form can incorporate drug delivery systems. Quercetin is known for its remarkable antioxidant capacity may have distinctive effect on healing. We designed constructed gelatin methacryloyl (GelMa) MNs carrying (Q-MNs). In vitro, the physical properties, cell safety, migration, angiogenesis, collagen formation, oxidative stress levels, were performed to characterize Q-MNs....
Hepatocellular carcinoma (HCC) is a fatal disease and patients with HCC frequently die from metastasis. The mechanisms of metastasis are not completely understood. In the present study, in vitro vivo data showed that cells promoted cancer cell proliferation lung metastases formation paracrinal/endocrinal way. We found HCC-derived exosomes mediated this phenomenon observed enhanced adhesion presence these malignant exosomes. further identified reactive oxygen species (ROS) regulated adhesive...
Triple-negative breast cancer (TNBC) is an aggressive subtype of cancer. Patients with TNBC have poor overall survival because limited molecular therapeutic targets. Recently, exosomes been recognized as key mediators in progression, but the components and function TNBC-derived remain unknown. The main goal this study was to reveal proteomic landscape serum derived from ten patients 17 healthy donors identify potential Using a tandem mass tag–based quantitative proteomics approach, we...
Abstract Ferroptosis, an iron‐dependent form of regulated cell death driven by excessive accumulation lipid peroxides, has become a promising strategy in cancer treatment. Cancer cells exploit antioxidant proteins, including Ferroptosis Suppressor Protein 1 (FSP1), to prevent ferroptosis. In this study, it is found that the E3 ubiquitin ligase TRIM21 bound FSP1 and mediated its ubiquitination on K322 K366 residues via K63 linkage, which essential for membrane translocation ferroptosis...
Abstract Heterogeneous cancer-associated fibroblasts (CAFs) play important roles in cancer progression. However, the specific biological functions and regulatory mechanisms involved endometrial have yet to be elucidated. We aimed explore potential of heterogeneous CAFs promoting The presence melanoma cell adhesion molecule (MCAM; CD146) positive was confirmed by tissue multi-immunofluorescence (mIF), fluorescence activated sorting (FACS). were determined wound healing assays, tuber formation...
Gliomas are the most aggressive primary intracranial malignancies with poor overall survival. ITGA5 is one member of integrin adhesion molecule family and implicated in cancer metastasis oncogenesis. However, few studies have explored association between tumor immune microenvironment expression level gliomas. Firstly, we analyzed 3,047 glioma patient samples collected from TCGA, CGGA, GEO databases, proving that high positively related to clinicopathological features survival patients. Then,...
Abstract Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide because metastasis. An increasing number studies have reported that cancer‐associated fibroblasts (CAFs) emerged as largest component stroma and play a critical role in tumor‐promoting processes. However, effects CAFs on cancer progression sensitivity hepatoma cells to sorafenib are not well characterized. Here, we identified proteome CAF‐derived exosomes, unveiled exosomal Gremlin‐1 derived from...
Background Orofacial clefts are the most common congenital malformation, but global burden and trends of orofacial have not been comprehensively analysed. The aim this study was to assess incidence, deaths disability-adjusted life years (DALYs) by countries, regions, sex sociodemographic index (SDI) from 1990 2019.Methods data on were obtained Global Burden Disease Study 2019. DALYs analysed SDI. Age-standardized rates estimated annual percentage change (EAPC) calculated evaluate temporal...
// Josette Northcott 1 , Gabor Bartha Jason Harris Conan Li Fabio C.P. Navarro Rachel Marty Pyke Manqing Hong Qi Zhang Shuyuan Ma Tina X. Chen Janet Lai Nitin Udar Juan-Sebastian Saldivar Erin Ayash Joshua Anderson Jiang Tiange Cui Tu Le Ruthie Chow Randy Jerel Velasco Chris Mallo Rose Santiago Robert C. Bruce Laurie J. Goodman Yi Dan Norton Richard O. * and John M. Lyle Personalis, Inc., Fremont, CA 94555, USA Co-last authors Correspondence to: Lyle, email: john.lyle@personalis.com...
In a series of studies to more precisely localize the cellular sites expression cyclin-dependent kinase (Cdk) family members in reproductive organs, we observed striking Cdk5 atretic follicles ovary, particularly granulosa cells that appeared be dying. We determined these were undergoing apoptotic cell death using thein situDNA fragmentation assay. To extend generality association with cells, examined its as it correlated detection apoptosis number developmental paradigms, including regions...