A5100349548- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Glycosylation and Glycoproteins Research
- Renal and related cancers
- Lung Cancer Research Studies
- Circular RNAs in diseases
- Molecular Biology Techniques and Applications
- Intracranial Aneurysms: Treatment and Complications
- Renal cell carcinoma treatment
- Cancer Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Traumatic Brain Injury and Neurovascular Disturbances
- Carbohydrate Chemistry and Synthesis
- Angiogenesis and VEGF in Cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer Mechanisms and Therapy
- Microtubule and mitosis dynamics
- PI3K/AKT/mTOR signaling in cancer
- Metastasis and carcinoma case studies
- Wnt/β-catenin signaling in development and cancer
Peking University
2008-2025
Peking University Third Hospital
2024-2025
Shandong University
2020-2025
Chang'an University
2024
Fuyang Second People's Hospital
2024
Anhui Medical University
2019-2024
Xijing Hospital
2024
Pfizer (United States)
2024
Shanghai Children's Medical Center
2024
Hebei Medical University
2018-2024
The majority of breast cancer patients die metastasis rather than primary tumors, whereas the molecular mechanisms orchestrating remains poorly understood. Long noncoding RNAs (lncRNA) have been shown to regulate occurrence and progression. However, lncRNAs that drive in their underlying are still largely unknown.lncRNAs highly expressed metastatic lymph nodes were identified by microarray. Survival analysis made Kaplan-Meier method. Cell proliferation, migration, invasion assay was...
Abstract Curcumin (diferuloylmethane), a polyphenol natural product of the plant Curcuma longa , is undergoing early clinical trials as novel anticancer agent. However, mechanism curcumin remains to be elucidated. Here we show that inhibited growth rhabdomyosarcoma cells (Rh1 and Rh30) (IC 50 = 2–5 μM) arrested in G 1 phase cell cycle. also induced apoptosis basal or type I insulin‐like factor‐induced motility cells. At physiological concentrations (˜2.5 μM), rapidly phosphorylation...
Abstract Background MicroRNA-200c (miR-200c) is one of the short noncoding RNAs that play crucial roles in tumorigenesis and tumor progression. It also acts as considerable modulator process epithelial-to-mesenchymal transition (EMT), a cell development regulating affects metastasis. However, role miR-200c bladder cancer cells its mechanism has not been well studied. The purpose this study was to determine potential EMT how it contributed invasion, migration proliferation. Methods Real-time...
Hepatocellular carcinoma (HCC) is the fifth most common cancer in world and third leading cause of cancer-related death. Critical roles for long non-coding RNAs (lncRNAs) have recently been demonstrated a variety cancers, including hepatocellular carcinoma. However, effect mechanism lncRNAs HCC tumorigenesis chemoresistance not extensively characterized.In current study, we identified HCC-expressed lncRNA termed as HANR (HCC associated RNA). We by microarray analysis validated its...
OBJECT Tenascin-C (TNC), a matricellular protein, is induced in the brain following subarachnoid hemorrhage (SAH). The authors investigated if TNC causes edema and blood-brain barrier (BBB) disruption experimental SAH. METHODS C57BL/6 wild-type (WT) or knockout (TNKO) mice were subjected to SAH by endovascular puncture. Ninety-seven randomly allocated WT sham-operated (n = 16), TNKO 34), 31) groups. Mice examined means of neuroscore water content 24-48 hours post-SAH; Evans blue dye...
Background and Purpose— A matricellular protein tenascin-C is implicated in early brain injury after experimental subarachnoid hemorrhage (SAH). This study first evaluated the role of another periostin relationships with post-SAH injury. Methods— Wild-type (n=226) knockout (n=9) C57BL/6 male adult mice underwent sham or filament perforation SAH modeling. Vehicle, anti-periostin antibody, recombinant was randomly administrated by an intracerebroventricular injection at 30 minutes...
Abstract The lack of efficient biomarkers for the early detection gastric cancer (GC) contributes to its high mortality rate, so it is crucial discover novel diagnostic targets GC. Recent studies have implicated potential site‐specific glycans in diagnosis, yet challenging perform highly reproducible and sensitive glycoproteomics analysis on large cohorts samples. Here, a robust N‐glycoproteomics (HRN) platform comprising an automated enrichment method, stable microflow LC‐MS/MS system,...
Abstract Introduction Human induced pluripotent stem cells (hiPSCs) are considered as one of the most promising seed cell sources in regenerative medicine. Now hiPSC-based clinical trials underway. To ensure safety, used or therapies should be generated under GMP conditions, and with Xeno-free culture media to avoid possible side effects like immune rejection that by Xeno reagents. However, up now there no reports for hiPSC lines developed completely conditions using Methods Clinical-grade...
Abstract As a unique and unappreciated protein posttranslational modification, arginine N ‐glycosylation was recently discovered to play an important role in the process that bacteria counteract host defenses. To provide chemical tools for further proteomic biochemical studies on ‐glycosylation, we report first general strategy rapid cost‐effective synthesis of glycopeptides carrying single or multiple ‐GlcNAcyl groups. These were successfully utilized generate antibodies can specifically...
Abstract Background Pulmonary arterial smooth muscle cell (PASMC) proliferation plays a crucial role in hypoxia-induced pulmonary hypertension (HPH). Previous studies have found that resistin-like molecule β (RELM-β) is upregulated de novo response to hypoxia cultured human PASMCs (hPASMCs). RELM-β has been reported promote hPASMC and involved vascular remodeling patients with PAH. However, the expression pattern, effects, mechanisms of action HPH remain unclear. Methods We assessed...
The development of chemical and enzymatic methods for the synthesis homogeneous glycoproteins is a fascinating challenge at interface between chemistry biology. Discussed here are currently available preparation glycoproteins. These include (1) glycopeptide ligation; (2) glycoprotein remodeling; (3) in vivo suppressor tRNA technology.
Abstract Background EST sequencing is one of the most efficient means for gene discovery and molecular marker development, can be additionally utilized in both comparative genome analysis evaluation duplications. While much progress has been made catfish genomics, large-scale resources have lacking. The objectives this project were to construct primary cDNA libraries, conduct initial generate resources, obtain baseline information about highly expressed genes various organs provide a guide...
// Fan Zeng 1 , Rui-Jun Ju Lei Liu Hong-Jun Xie Li-Min Mu Yao Zhao Yan Ying-Jie Hu Jia-Shuan Wu Wan-Liang Lu Beijing Key Laboratory of Molecular Pharmaceutics and New Drug System, State Natural Biomimetic Drugs, School Pharmaceutical Sciences, Peking University, 100191, China Correspondence to: Lu, e-mail: luwl@bjmu.edu.cn Keywords: functional liposome, vincristine, dasatinib, vasculogenic mimicry channel, triple-negative breast cancer Received: July 12, 2015 Accepted: September 16,...
Incomplete understanding remains in the molecular mechanisms underlying progression and metastasis of renal cancer. The transcription factor SOX4 is upregulated various human malignancies, including cancer, indicating it may be involved tumorigenesis. In this study, we explored hypothesis by loss-of-function gain-of-function assays cancer cell lines epithelial line. We found that specific knockdown significantly suppressed migration invasion cells; overexpression line markedly promoted...