A5039273714- Aquaculture disease management and microbiota
- Invertebrate Immune Response Mechanisms
- Genetic diversity and population structure
- Aquaculture Nutrition and Growth
- Fish Ecology and Management Studies
- Identification and Quantification in Food
- Genomics and Phylogenetic Studies
- Immune Response and Inflammation
- Animal Genetics and Reproduction
- Genetic and phenotypic traits in livestock
- Fish Biology and Ecology Studies
- Molecular Biology Techniques and Applications
- Vibrio bacteria research studies
- Antimicrobial Peptides and Activities
- Reproductive biology and impacts on aquatic species
- Fish biology, ecology, and behavior
- interferon and immune responses
- Chromosomal and Genetic Variations
- RNA and protein synthesis mechanisms
- Physiological and biochemical adaptations
- Marine Bivalve and Aquaculture Studies
- Iron Metabolism and Disorders
- Gut microbiota and health
- Trace Elements in Health
- Chemokine receptors and signaling
Auburn University
2015-2024
Kentucky State University
2019
Emory University
2008-2012
Iowa State University
2010
Recent evidence has linked intestinal permeability to mucosal inflammation, but molecular studies are lacking. Candidate regulatory molecules localized within the tight junction (TJ) include Junctional Adhesion Molecule (JAM-A), which been implicated in regulation of barrier function and leukocyte migration. Thus, we analyzed mucosa JAM-A–deficient (JAM-A−/−) mice for enhanced inflammation. Colonic from JAM-A−/− had normal epithelial architecture increased polymorphonuclear infiltration...
Abstract Catfish represent 12% of teleost or 6.3% all vertebrate species, and are enormous economic value. Here we report a high-quality reference genome sequence channel catfish ( Ictalurus punctatus ), the major aquaculture species in US. The was validated by genetic mapping 54,000 SNPs, annotated with 26,661 predicted protein-coding genes. Through comparative analysis genomes transcriptomes scaled scaleless fish scale regeneration experiments, address genomic basis for most striking...
Temperature is one of the most prominent abiotic factors affecting ectotherms. Most fish species, as ectotherms, have extraordinary ability to deal with a wide range temperature changes. While molecular mechanism underlying adaptation has long been interest, it still largely unexplored fish. Understanding fundamental mechanisms conferring tolerance fluctuations topic increasing interest may continue rise result global climate change. Catfish natural habitat and possess great plasticity in...
Single nucleotide polymorphisms (SNPs) have become the marker of choice for genome-wide association studies. In order to provide best genome coverage analysis performance and production traits, a large number relatively evenly distributed SNPs are needed. Gene-associated may fulfill these requirements numbers wide distribution. addition, gene-associated could themselves be causative traits. The objective this project was identify using high-throughput next generation sequencing....
Upon the completion of whole genome sequencing, thorough annotation that associates sequences with biological meanings is essential. Genome depends on availability transcript information as well orthology information. In teleost fish, seriously hindered by duplication. Because gene duplications, one cannot establish orthologies simply homology comparisons. Rather intense phylogenetic analysis or structural required for identification genes. To conduct and analysis, full-length transcripts...
Abstract During mucosal inflammation, a complex array of proinflammatory and protective mechanisms regulates inflammation severity injury. Secretion anti-inflammatory mediators is mechanism that critical in controlling inflammatory responses promoting epithelial restitution barrier recovery. AnxA1 potent protein has been implicated to play immune regulatory role models inflammation. Although shown be secreted intestinal tissues during its potential modulating the injury/inflammatory response...
Abstract Background SNPs are abundant, codominantly inherited, and sequence-tagged markers. They highly adaptable to large-scale automated genotyping, therefore, most suitable for association studies applicable comparative genome analysis. However, discovery of requires sequencing efforts through whole or deep reduced representation libraries. Such resources not yet available many species including catfish. A large resource ESTs is become in catfish allowing identification number SNPs, but...
Abstract Background Gene duplication has had a major impact on genome evolution. Localized (or tandem) resulting from unequal crossing over and whole are believed to be the two dominant mechanisms contributing vertebrate While much scrutiny been directed toward discerning patterns indicative of whole-genome events in teleost species, less attention paid continuous nature gene duplications their size, content, functional diversity, overall architecture genomes. Results Here, using Markov...
Through the Community Sequencing Program, a catfish EST sequencing project was carried out through collaboration between research community and Department of Energy's Joint Genome Institute. Prior to this project, only limited resource from available for purpose SNP identification.A total 438,321 quality ESTs were generated 8 channel (Ictalurus punctatus) 4 blue furcatus) libraries, bringing number nearly 500,000. Assembly all resulted in 45,306 contigs 66,272 singletons. Over 35% unique...