A5044063970- Aquaculture disease management and microbiota
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- MicroRNA in disease regulation
- Genomics and Phylogenetic Studies
- Genetic and phenotypic traits in livestock
- RNA modifications and cancer
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Aquaculture Nutrition and Growth
- Molecular Biology Techniques and Applications
- Sperm and Testicular Function
- Reproductive biology and impacts on aquatic species
- Ichthyology and Marine Biology
- Circular RNAs in diseases
- Physiological and biochemical adaptations
- Animal Genetics and Reproduction
- Cancer-related gene regulation
- Complement system in diseases
- Chromosomal and Genetic Variations
- Extracellular vesicles in disease
- Protein Hydrolysis and Bioactive Peptides
- RNA and protein synthesis mechanisms
- Identification and Quantification in Food
- Heat shock proteins research
Qingdao University
2023-2025
Michigan State University
2019-2024
Auburn University
2016-2022
Henan University of Science and Technology
2022
East China Normal University
2018
Southern Medical University
2013
McGill University
2011
Abstract Catfish represent 12% of teleost or 6.3% all vertebrate species, and are enormous economic value. Here we report a high-quality reference genome sequence channel catfish ( Ictalurus punctatus ), the major aquaculture species in US. The was validated by genetic mapping 54,000 SNPs, annotated with 26,661 predicted protein-coding genes. Through comparative analysis genomes transcriptomes scaled scaleless fish scale regeneration experiments, address genomic basis for most striking...
Sex determination mechanisms in teleost fish broadly differ from mammals and birds, with sex chromosomes that are far less differentiated recombination often occurring along the length of X Y chromosomes, posing major challenges for identification specific genes. Here, we take an innovative approach comparative genome analysis genomic sequences chromosome newly sequenced channel catfish. Using a YY catfish as sequencing template, generated, assembled, annotated sequence The assembly had...
Spermatogonial stem cells (SSCs) are the foundation of spermatogenesis and represent a crucial resource for male fertility restoration. It has not been well documented, however, whether recovery SSC population size after cytotoxic damage associates with kinetics We addressed this issue using mouse as model.Following single injections busulfan at 15, 30 or 45 mg/kg into mice, we examined their ability to sire offspring different times by natural mating determined numbers spermatogonial...
Abstract Genetic mapping to identify genes and alleles associated with or causing economically important quantitative trait variation in livestock animals such as pigs is a major goal animal genetic improvement. Despite recent advances high-throughput genotyping technologies, the resolution of remains poor due part low density genotyped variant sites. In this study, we overcame limitation by developing reference haplotype panel for based on 2259 whole genome-sequenced representing 44 pig...
Summary Heat tolerance is a complex and economically important trait for catfish genetic breeding programs. With global climate change, it becoming an increasingly trait. To better understand the molecular basis of heat stress, genome‐wide association study ( GWAS ) was carried out using 250 K SNP array with interspecific backcross progenies, which derived from crossing female channel male F1 hybrid (female × blue catfish). Three significant associated s were detected by performing EMMAX...
A bioenergetic balance between glycolysis and mitochondrial respiration is particularly important for stem cell fate specification. It however remains to be determined whether undifferentiated spermatogonia switch their preference bioenergy production during differentiation. In this study, we found that ATP generation in was gradually increased upon retinoic acid (RA)-induced To accommodate elevated energy demand, RA signaling concomitantly switched from respiration, accompanied by levels of...
The X and Y chromosomes of channel catfish have the same gene contents. Here, we report allelic hypermethylation chromosome within sex determination region (SDR). Accordingly, X-borne hydin-1 was silenced, whereas Y-borne expressed, making monoallelic expression responsible for determination, much like genomic imprinting. Treatment with a methylation inhibitor, 5-aza-dC, erased epigenetic marks SDR caused reversal genetic females into phenotypic males. After treatment, six other genes...
Channel catfish has an XY sex determination system. However, the X and Y chromosomes harbor identical gene content of 950 genes each. In this study, we conducted comparative analyses methylome transcriptome genetic males females before gonadal differentiation to provide insights into mechanisms determination. Differentially methylated CpG sites (DMCs) were predominantly identified on chromosome, most notably within region (SDR), although overall methylation profiles across entire genome...