A5103086862- Renal and related cancers
- Renal cell carcinoma treatment
- Lung Cancer Treatments and Mutations
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- Lung Cancer Research Studies
- Chemokine receptors and signaling
- Nutrition and Health in Aging
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Endoplasmic Reticulum Stress and Disease
- Sepsis Diagnosis and Treatment
- Fungal Biology and Applications
- Immune Response and Inflammation
- Muscle Physiology and Disorders
- Colorectal Cancer Treatments and Studies
- RNA Interference and Gene Delivery
- Prostate Cancer Treatment and Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Renal Diseases and Glomerulopathies
- Cytokine Signaling Pathways and Interactions
First Affiliated Hospital of Zhengzhou University
2024-2025
Nanchang University
2025
Huazhong University of Science and Technology
2014-2024
Central Hospital of Wuhan
2020-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Peking Union Medical College Hospital
2021-2024
Xiyuan Hospital
2024
Zhongnan Hospital of Wuhan University
2020
Wuhan University
2020
Union Hospital
2016-2018
We previously performed microRNA (miRNA) microarray to identify effective indicators of clear cell renal carcinoma (ccRCC) tissue samples and preoperative/postoperative plasma in which we identified miR-144-3p as an oncomiRNA. However, the molecular mechanism remains unclear. This study aims explore roles invasion, migration Sunitinib-resistance ccRCC elucidate underlying mechanisms.Gain loss function approaches were used investigate proliferation, cycle distribution, clonogenicity,...
Neuroendocrine prostate cancer (NEPC) is a lethal subtype of cancer. It characterized by the loss androgen receptor (AR) signaling in neuroendocrine transdifferentiation, and finally, resistance to AR-targeted therapy. With application new generation potent AR inhibitors, incidence NEPC gradually increasing. The molecular mechanism differentiation (NED) after deprivation therapy (ADT) remains largely unclear. In this study, using NEPC-related genome sequencing database analyses, we screened...
Incomplete understanding remains in the molecular mechanisms underlying progression and metastasis of renal cancer. The transcription factor SOX4 is upregulated various human malignancies, including cancer, indicating it may be involved tumorigenesis. In this study, we explored hypothesis by loss-of-function gain-of-function assays cancer cell lines epithelial line. We found that specific knockdown significantly suppressed migration invasion cells; overexpression line markedly promoted...
Scavenger receptor class B type I (SR-BI) has been reported to be involved in carcinogenesis of several human cancers. However, it is currently unknown whether SR-BI plays a role clear cell renal carcinoma (ccRCC). Here, we aimed evaluate tumor promotive mechanism for ccRCC. The expression was evaluated by real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR), Western blot and immunohistochemistry (IHC) ccRCC tissues lines. Lipid droplets normal kidney were...
Muscle wasting is the hallmark of cancer cachexia and associated with poor quality life increased mortality. Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, has important biological effects in treatment muscular dystrophy. To verify whether VPA could ameliorate muscle induced by cachexia, we explored role two cachectic mouse models [induced colon-26 (C26) adenocarcinoma or Lewis lung carcinoma (LLC)] atrophied C2C12 myotubes C26 cell conditioned medium (CCM) LLC (LCM)]. Our data...
Growing evidence suggests that hepatitis C virus (HCV) contributes to hepatocellular carcinoma (HCC) by directly modulating oncogenic signaling pathways. Protein phosphatase magnesium-dependent 1A (PPM1A) has recently emerged as an important tumor suppressor it can block a range of tumor-centric pathways through protein dephosphorylation. However, the role and regulatory mechanisms PPM1A in HCV-infected cells have not been reported. Total, cytoplasmic, nuclear after HCV infection or...
Fli-1 has emerged as a critical regulator of inflammatory mediators, including MCP-1, CCL5, and IL-6. The cytokine, granulocyte colony stimulating factor (G-CSF) regulates neutrophil precursor maturation survival, activates mature neutrophils. Previously, significant decrease in infiltration into the kidneys Fli-1+/- lupus-prone mice was observed. In this study, G-CSF protein expression detected stimulated murine human endothelial cells when inhibited. promoter contains numerous putative...
Biomarkers to guide the clinical treatment of patients with renal cell carcinoma (RCC) are not yet routinely available. MicroRNAs (miRNAs) have been demonstrated serve as biomarkers for a number types cancer. Based on previous study by this group, we hypothesize that several highly differentially expressed miRNAs may tissue and plasma in RCC. The expression levels miR-210, miR-224 miR-141 were analyzed samples from same cohort 78 RCC, paired pre- post-operative 66 clear RCC (ccRCC) 67...
Abstract Background The identification of early plasma biomarkers for clinical outcomes and drug resistance has key importance risk stratification in anaplastic lymphoma kinase ( ALK )-positive advanced non-small cell lung cancer (NSCLC) patients. Moreover, it remains unclear whether the anti-angiogenic anlotinib can reverse ALK-tyrosine inhibitor (ALK-TKI) crizotinib, no research explored effect combined with crizotinib on -positive Methods In this study, 76 baseline longitudinal samples...
We explored whether initially determined procalcitonin (PCT) levels could facilitate assessment of the risks infection and death due to treatment failure in patients with non-Hodgkin lymphoma (NHL) newly developed febrile neutropenia (FN). In 212 examined episodes, initial PCT value was markedly higher microbiologically documented (MDI) or clinically compared fevers unknown origin (p < 0.001 for both). Patients values ≥ 0.50 ng/mL were at high risk MDI (sensitivity 83.5%, specificity 77.2%)....
We investigated the prognostic significance of Death-Associated Protein Kinase 1 (DAPK1) and its role in sunitinib resistance clear cell renal carcinoma (ccRCC). DAPK1 mRNA levels were significantly lower tumor tissues than normal kidney TCGA-KIRC dataset (n=428). Both overall survival disease-free shorter ccRCC patients with low expression those high expression. Receiver operating characteristic curve analysis showed that correlated poor prognosis patients. Multivariate confirmed was an...
CXCL12/CXCR4 has been studied as an important biomarker for many human malignancies, but studies are limited esophageal squamous cell carcinoma (ESCC). In this study, effective RNAi sequence targeting the CXCR4 gene was selected, a lentiviral shRNA vector constructed to specifically silence expression in EC9706 ESCC line, and effects of silencing on growth vitro tumour nude mice were then evaluated. The significantly downregulated after transfection with vector. apoptosis-related Bcl-2...
Background: Invasion and metastasis led to poor prognosis death of clear cell renal carcinoma (ccRCC) patients. The deoxynucleotidyl transferase terminal interacting protein 1 (DNTTIP1) was reported promote multiple tumor progression. However, there is no research about DNTTIP1 in ccRCC. Methods: Kaplan–Meier survival analysis, multivariate analysis demonstrated the prognostic indicator overall (OS) disease-free (DFS) ccRCC with expression Cancer Genome Atlas Kidney Clear Cell Carcinoma...
Transforming growth factor-beta1 (TGF-beta1) is believed to be a key player in wound healing, promoting cell proliferation, migration, and matrix synthesis variety of types. We have designed two peptides, i.e., cytomodulin-1 (CM-1) cytomodulin-2 (CM-2), simulate the binding domain TGF-beta1. In this study we examined bioactivity synthetic peptides CM-1 CM-2 on human foreskin fibroblasts (HFF). Synthetic culture media increased healing an injury model vitro. addition, enhanced gene expression...
Aberrant expression of scavenger receptor class B type 1 has been reported in several human cancers. Nevertheless, the roles clear cell renal carcinoma remain unclear. The aim this study was to evaluate diagnostic and prognostic value carcinoma. messenger RNA level tissues detected by quantitative reverse transcription polymerase chain reaction, while protein determined western blot immunohistochemistry. lipid content between normal kidney differentiated Oil Red O hematoxylin-eosin staining....
Clear cell renal carcinoma (ccRCC) has the highest incidence rate among all pathological types of kidney cancers. Although role transient receptor potential (TRP) ion channel TRPM2 been studied in many cancers, its function ccRCC is still unexplored. In this study, using KIRC module TCGA, we found that was upregulated tissues and related to poor prognosis. Gene set enrichment analysis (GSEA) showed epithelial-to-mesenchymal transition (EMT), TCA cycle, fatty acid metabolism, immune...
Postoperative respiratory complications often arise in lung cancer patients after resection, although these are difficult to predict. We sought identify reliable predictors of early-onset postoperative who had moderate-to-severe preoperative impairment.This was a prospective observational study that included 107 consecutive with forced expiratory volume 1 s <60% predicted were scheduled for thoracotomy and resection. Preoperative functional assessments pulmonary function testing by...