A5008382997- Monoclonal and Polyclonal Antibodies Research
- Lung Cancer Treatments and Mutations
- Immunotherapy and Immune Responses
- Lymphoma Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Lung Cancer Research Studies
- Advanced Biosensing Techniques and Applications
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Chronic Lymphocytic Leukemia Research
- Lung Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Viral-associated cancers and disorders
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Ferroptosis and cancer prognosis
- Gastric Cancer Management and Outcomes
- Cancer therapeutics and mechanisms
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Peptidase Inhibition and Analysis
- Cancer Treatment and Pharmacology
- Medical Imaging and Pathology Studies
- CNS Lymphoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Peking Union Medical College Hospital
2015-2025
Shenzhen Second People's Hospital
2021-2025
Zhejiang University
2025
Nanjing Medical University
2024
Hebei University of Engineering
2023-2024
Fujian Agriculture and Forestry University
2022-2024
Xiyuan Hospital
2023-2024
National Medical Products Administration
2024
Guangdong Institute for Drug Control
2024
Human uptake abundance of microplastics via various pathways, and they accumulate in human liver, kidney, gut even placenta (especially with a diameter 1 μm or less). Recent scientific studies have found that exposure to causes intestinal inflammation liver metabolic disorder, but it remains largely unknown whether the damage may cause further development severe diseases. In this study, we discovered one such potential diseases be induced by small-sized (with μm) performing multi-organ...
Epidermal growth factor receptor (EGFR) mutations are the strongest response predictors to EGFR tyrosine kinase inhibitors (TKI) therapy, but knowledge of mutation frequency on lung adenocarcinoma is still limited retrospective studies. The PIONEER study (NCT01185314) a prospective molecular epidemiology in Asian patients with newly diagnosed advanced adenocarcinoma, aiming prospectively analyze status IIIB/IV treatment-naïve adenocarcinomas Asia. We report mainland China subset results....
Abstract Antitumor T lymphocytes play a pivotal role in immunosurveillance of malignancy. The CTL antigen 4 (CTLA-4) is vital negative regulator T-cell activation and proliferation. This study examined whether genetic polymorphisms CTLA-4 are associated with cancer susceptibility. A two-stage investigation using haplotype-tagging single nucleotide polymorphism approach multiple independent case-control analyses was performed to assess the association between genotypes risk. Functional...
Altered expression of heat shock protein 90 alpha (Hsp90α) was associated with tumor development, progression, and metastasis. This study explored plasma levels Hsp90α in patients lung cancer other controls to assess its diagnostic value monitor treatment responses for cancer.A total 2,247 individuals were recruited assigned into two cohorts as static dynamic groups. ELISA analysis confirmation association stages responses, respectively, performed.The average significantly higher than...
IntroductionAlflutinib (AST2818) is a newly developed third-generation EGFR tyrosine kinase inhibitor selective for EGFR-sensitizing and T790M-resistant mutations. We assessed the safety, efficacy, pharmacokinetics of alflutinib in patients with advanced NSCLC confirmed T790M mutation, whose status progressed after first- or second-generation therapy.MethodsIn dose-escalation (NCT02973763) dose-expansion (NCT03127449) studies, received orally until disease progression, unacceptable toxicity,...
<h3>Importance</h3> As the third most frequently mutated gene in cancers, association between<i>MUC16</i>mutation and response to immune checkpoint inhibitors (ICIs) solid tumors remains unclear. <h3>Objective</h3> To examine whether<i>MUC16</i>mutation is associated with genomic factors ICI outcomes ICI-treated patients. <h3>Design, Setting, Participants</h3> This cohort study used multidimensional data of 10 195 patients from The Cancer Genome Atlas (TCGA) across 30 tumor types, 56 a...
Abstract In hepatocellular carcinoma (HCC), classical cancer stem cells (CSC) markers were shared by normal cells, targeting which may hinder hepatic regeneration and cause liver failure. Additionally, the spatial structure of CSC still remained elusive. To address these limitations, we undertook a comprehensive study combining single-cell data (56,022 from 20 samples) (38,191 spots eight to obtain signature uncover its structure. Utilizing CytoTRACE algorithm, discretely identified CSC,...
The FAS receptor–ligand system plays a key role in regulating apoptotic cell death, and corruption of this signaling pathway has been shown to participate tumor-immune escape carcinogenesis. We have recently demonstrated (Sun, T., X. Miao, Zhang, W. Tan, P. Xiong, D. Lin. 2004. J. Natl. Cancer Inst. 96:1030–1036; X., T. Sun, S. Qu, Y. Zhou, 2005. Med. Genet. 42:479–484) that functional polymorphisms ligand (FASL) are associated with susceptibility lung cancer esophageal cancer; however, the...
Mutations in KRAS oncogene are recognized biomarkers that predict lack of response to anti- epidermal growth factor receptor (EGFR) antibody therapies. However, some patients with wild-type tumors still do not respond, so other downstream mutations BRAF, PIK3CA and NRAS should be investigated. Herein we used direct sequencing analyze mutation status for 676 (codons 12, 13 61), BRAF (exon 11 exon 15), 9 20) (codons12, 61). Clinicopathological characteristics associations were analyzed...
Does pre-mixing stored serum samples with assay buffer improve the reproducibility of Beckman Gen II for anti-Müllerian hormone (AMH)?Pre-mixing is a prerequisite reproducible measurement AMH in using Coulter assay.Discrepancies results obtained from assays have raised doubts concerning clinical utility measuring AMH. Sample storage conditions may be responsible lack kit.This was prospective study which were at three different temperatures and assayed times 0, 4, 8, 12, 24, 48 h 1 or 2 weeks...
Abstract Context.—The immunophenotypic profile of basophils is not yet fully established, and the changes in chronic myelogenous leukemia are characterized. Objective.—To establish a comprehensive spectrum normal to assess range aberrations leukemia. Design.—Using 4-color flow cytometry, we compared peripheral blood or bone marrow samples from 20 patients with no evidence neoplasia 15 Results.—Basophils control cases were all positive for CD9, CD13, CD22, CD25 (dim), CD33, CD36, CD38...
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have become important treatment options for non-small cell lung cancer (NSCLC) patients with EGFR sensitive mutation. However, the detection of driver mutation is impeded by lack adequate tumor tissues, histopathological type, long period, and heterogeneity a tumor. Therefore, it necessary to develop more convenient method guide clinical use EGFR-TKI. Circular RNAs (circRNAs) are characterized as closed structure...
Clear cell renal carcinoma (ccRCC or KIRC) has a high mortality rate globally. It is necessary to identify biomarkers and investigate the mechanisms those are associated with, improve prognosis of patients with KIRC. N6-Methyladenosine (m6A) affects fate modified RNA molecules involved in tumor progression. Different webservers were used our research mRNA transcription clinical significance YTHDF2 Survival analysis revealed that elevated had slightly longer OS DFS than low expression....
Abstract Background Tunlametinib (HL-085) is a novel, highly selective MEK inhibitor with substantial clinical activities in patients NRAS -mutant melanoma. This phase I study evaluated the safety and preliminary efficacy of tunlametinib plus vemurafenib advanced BRAF V600-mutant solid tumors. Methods Patients confirmed tumors who had progressed on or shown intolerance no available standard therapies were enrolled received vemurafenib. consisted dose-escalation dose-expansion phase. Primary...
In the evolving field of precision oncology, synthesis gene circuits that specifically target cancer cells while preserving normal tissue marks a significant breakthrough. However, traditional approaches typically concentrate on single-gene targets, lacking directed recognition and control among intricate networks signaling pathways. Our study presents synthetic circuit, Logic “AND” Gate Dual-Target Genetic Circuit (LAG-DTGC), which integrates multiple signals to achieve comprehensive...
In a confined space, the flammability of alternative refrigerants (such as R717, R290, R32, and R1234yf) poses significant safety risks during leaks. However, in actual refrigeration systems, direction refrigerant leakage is difficult to predict, complicating explosion risk assessment. this work, R1234yf were selected research objects analyze diffusion process deposition characteristics different leaking vertically upward into explore migration flammable under amounts area space. The results...