A5100959069- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Biochemical and Molecular Research
- Synthesis and biological activity
- Immune Cell Function and Interaction
- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Pharmacovigilance and Adverse Drug Reactions
- Infectious Diseases and Tuberculosis
- Quinazolinone synthesis and applications
- Bacterial Infections and Vaccines
- Immune cells in cancer
- Neuroblastoma Research and Treatments
- interferon and immune responses
- Poisoning and overdose treatments
- Bacterial Identification and Susceptibility Testing
- thermodynamics and calorimetric analyses
- Signaling Pathways in Disease
- Heat shock proteins research
- Antimicrobial Resistance in Staphylococcus
- Acute Kidney Injury Research
- Inflammation biomarkers and pathways
- Galectins and Cancer Biology
- HIV/AIDS drug development and treatment
- Cancer Mechanisms and Therapy
Hebei Medical University
2006-2024
Second Hospital of Hebei Medical University
2006-2024
Harbin Medical University
2010-2020
PLA 306 Hospital
2011-2016
Hebei North University
2016
The 309th Hospital of Chinese People's Liberation Army
2003-2015
Beijing Center for Disease Prevention and Control
2013
Chinese People’s Liberation Army 263 hospital
2010
Third Affiliated Hospital of Harbin Medical University
2010
Novosibirsk Tuberculosis Research Institute
2010
Altered expression of heat shock protein 90 alpha (Hsp90α) was associated with tumor development, progression, and metastasis. This study explored plasma levels Hsp90α in patients lung cancer other controls to assess its diagnostic value monitor treatment responses for cancer.A total 2,247 individuals were recruited assigned into two cohorts as static dynamic groups. ELISA analysis confirmation association stages responses, respectively, performed.The average significantly higher than...
ABSTRACT Recombinant severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein was employed to establish an antigen-capturing enzyme-linked immunosorbent assay (ELISA). Antinucleocapsid antibodies could be detected in 68.4% of probable SARS patients 6 10 days after illness and 89.6% the 11 61 illness. No false-positive results were observed 20 non-SARS fever patients, 24 health care workers. Among 940 other clinical serum samples, only 1 found weakly positive. This method...
<b><i>Introduction:</i></b> Drug-induced acute kidney injury (D-AKI) is one of the important types AKI. The incidence D-AKI in China has rarely been studied. <b><i>Objective:</i></b> This study aims to explore disease burden, related drugs, and risk factors D-AKI. <b><i>Methods:</i></b> A nationwide cross-sectional survey was conducted adult patients from 23 academic hospitals 17 provinces China. Suspected AKI screened...
The diagnosis of smear-negative and culture-negative patients with active tuberculosis (TB) is challenging. detection Mycobacterium tuberculosis-specific antibodies in human sera has been an important diagnostic aid. However, antibody responses to a single antigen usually low sensitivity for TB. In this study, humoral immune against recombinant M. 38-kDa, MTB48, CFP-10/ESAT-6 (culture filtrate protein 10/6-kDa early secreted target tuberculosis) antigens 250 Chinese TB 260 healthy subjects...
Acetohydroxyacid synthase (AHAS) has been regarded as a promising drug target against Mycobacterium tuberculosis (MTB) it catalyzes the biosynthesis of branched-chain amino acids. In this study, 23 novel AHAS inhibitors were identified through molecular docking followed by similarity search. The determined IC50 values range from 0.385 ± 0.026 μM to >200 bacterium AHAS. Five compounds show significant in vitro activity H37Rv strains (MICs 2.5–80 mg/L) and clinical MTB strains, including MDR...
Tuberculosis (TB) is a disease of worldwide public-health concern. The development resistance to an increasing number second-line drugs and those used treat multidrug-resistant (MDR) TB rapidly becoming emergency that could hinder the prevention treatment globally. This study describes profile MDR extensively drug-resistant (XDR) with hospital-based survey in Beijing, China, conducted period 2007 2009. Drug-susceptibility tests performed on 967 Mycobacterium tuberculosis strains isolated...
The in vitro activity of linezolid was evaluated against 84 clinical isolates Mycobacterium tuberculosis, including multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains, isolated from the center for tuberculosis research treatment Chinese army. Linezolid showed excellent activity, with minimum inhibitory concentrations (MICs) 0.125–0.5 μg/mL all tested isolates. There were no differences MIC50 MIC90 between susceptible, isoniazid-resistant, MDR, XDR. Indeed, groups...
The aim of this study was to establish an animal model experimental allergic encephalomyelitis (EAE) and examine the basic pathological changes, as well expression distribution MMP‐2 MMP‐9, in Wistar rats. Tissue sections were processed for HE staining, Weil myelin modified Bielschowsky staining. Expression glial fibrillary acidic protein (GFAP), matrix metalloproteinase‐2 (MMP‐2) metalloproteinase‐9 (MMP‐9) detected with immunohistochemistry. We divided EAE into five types, depending on...
This study was to evaluate the resistance of antimicrobial agents against pathogens from inpatients with nosocomial infection collected in Beijing, China, during 2011–2014. Measurement minimum inhibitory concentrations (MICs) carried out using broth microdilution method Clinical and Laboratory Standards Institute (CLSI) guidelines as indicator. A total 5442 Gram-negative 806 Gram-positive isolates were this Two carbapenem-resistant strains appeared among Escherichia coli (E. coli), while...
Methicillin-resistant Staphylococcus aureus (MRSA) has been a public health concern since it was first identified in the United Kingdom 1961. In this study, we investigated prevalence of MRSA PLA 309 Hospital located Beijing, China, and determined susceptibility S. to novel oxazolidinone analogs 13 conventional antimicrobial agents. It shown that drug resistant patterns were severe among clinical isolates, average rate strains 56.3%. All tested completely susceptible linezolid, but minimum...
In this study we investigated the prevalence of antimicrobial resistance in clinical isolates Gram-negative bacteria obtained from intensive care units (ICUs) people's liberation Army (PLA) 309 Hospital located Beijing, China. Between 2007 and 2010, a total 1949 were collected tested using an antibiotic susceptibility assay. A marked decrease was observed Acinetobacter baumannii to imipenem amikacin as compared that described previous report Similar results for Pseudomonas aeruginosa....
Background The early identification of Alzheimer's disease (AD) benefits patients, so creating a simple and convenient method is crucial for diagnosing symptoms. Objective To offer potential approach the detection both AD mild cognitive impairment (MCI). Methods Eye movement data from 66 patients were divided into three groups, including healthy control group (HC), MCI group, group. We searched parameters that can detect at an stage drew receiver operating characteristic (ROC) curves....
Neuroblastoma (NB) is a common solid tumor in children and infants, with its formation regression closely linked to the tumor-host immune mechanism. STING agonists, particularly cyclic dinucleotide (CDN), have promising potential NB therapy by generating innate adaptive stimulation, leading control. In vivo CDN delivery challenging due negative charge, hydrophilicity, susceptibility degradation phosphodiesterase, hindering effectiveness. Thus, our study proposed four methods load into...