A5014244334- melanin and skin pigmentation
- Skin Protection and Aging
- Renal Diseases and Glomerulopathies
- Cancer-related molecular mechanisms research
- Biochemical Analysis and Sensing Techniques
- Acute Kidney Injury Research
- Phytochemicals and Antioxidant Activities
- Pharmacy and Medical Practices
- Mycobacterium research and diagnosis
- Cancer, Hypoxia, and Metabolism
- Tuberculosis Research and Epidemiology
- Dermatology and Skin Diseases
- Immunodeficiency and Autoimmune Disorders
- Acne and Rosacea Treatments and Effects
- Gut microbiota and health
- Cardiac Valve Diseases and Treatments
- RNA modifications and cancer
- Higher Education and Teaching Methods
- RNA regulation and disease
- Olfactory and Sensory Function Studies
- Pregnancy and preeclampsia studies
- Chronic Kidney Disease and Diabetes
- Metabolism and Genetic Disorders
- Anesthesia and Neurotoxicity Research
- Cardiovascular Health and Risk Factors
Chongqing Public Health Medical Center
2021-2024
Southwest University
2024
Central South University
2005-2024
Third Xiangya Hospital
2018-2024
Peking University
2024
Peking University Third Hospital
2024
The First People's Hospital of Changde
2024
Guangdong University of Technology
2024
Southwest Medical University
2024
Yunnan University
2024
Abstract Ultraviolet (UV)‐induced pigmentation is very common in clinical practice, but the current treatments are rarely effective, accompanied by some side effects. Ganoderma lucidum polysaccharide (GLP) a natural antioxidant with no toxic effects, which can antagonize UVB‐induced fibroblast photo aging. The study aims to explore role of GLP inhibiting melanogenesis and its possible mechanism. expression genes such as microphthalmia‐associated transcription factor (MITF), tyrosine (TYR),...
Abstract Keratinocytes are closely associated with innate immunity and inflammatory responses, dysregulated during the development of psoriasis, but underlying mechanisms not yet fully understood. This work aims to reveal effects long non-coding RNA (lncRNA) UCA1 in psoriatic keratinocytes. was identified as a psoriasis-related lncRNA that highly expressed lesions. The transcriptome proteome data keratinocyte cell line HaCaT showed could positively regulate functions, such response cytokine....
A minimally invasive, highly efficient and versatile strategy is proposed for localized tumor regression by developing a smart injectable liquid–solid phase-transformation organic–inorganic hybrid composite material, i.e., magnetic-Fe-powder-dispersed PLGA (Fe/PLGA) implants magnetic hyperthermia therapy of cancer. As service to our authors readers, this journal provides supporting information supplied the authors. Such materials are peer reviewed may be re-organized online delivery, but not...
Abstract As a main part of pigmentation disorders, skin depigmentation diseases such as vitiligo and achromic naevus are very common get more attention now. The pathogenesis includes melanocyte dysfunction loss, which possibly caused by heredity, autoimmunity oxidative stress. Among them, stress plays key role; however, few clinical treatments can deal with reported, Cistanche deserticola polysaccharide (CDP) is an effective antioxidant; based on that, we evaluated its role in further...
<b><i>Introduction:</i></b> Drug-induced acute kidney injury (D-AKI) is one of the important types AKI. The incidence D-AKI in China has rarely been studied. <b><i>Objective:</i></b> This study aims to explore disease burden, related drugs, and risk factors D-AKI. <b><i>Methods:</i></b> A nationwide cross-sectional survey was conducted adult patients from 23 academic hospitals 17 provinces China. Suspected AKI screened...
Limb remote ischemic postconditioning (LRIP) can ameliorate cerebral ischemia–reperfusion injury (IRI), while the underlying mechanism remains elusive. Hypoxia-inducible factor 1α (HIF-1α) is an important transcription during ischemia damage. However, whether neuroprotective effect of LRIP could be associated with HIF-1α somewhat unclear. Here we tested hypothesis that protecting brain from in middle artery occlusion (MCAO) rat model was expression. conducted 3 cycles 10 min occlusion/10...
To evaluate the diagnostic accuracy of matrix-assisted laser desorption ionization time-of-flight mass spectrometry based on nucleotide (nucleotide MALDI-TOF MS) bronchoalveolar lavage fluid (BALF) from suspected pulmonary tuberculosis (PTB) patients. A retrospective study was conducted PTB patients (total 960) admitted to Chongqing Public Health Medical Center between May 2021 and January 2022. The sensitivity, specificity, positive predictive value, negative value (NPV) area under curve...
It has been reported that oligodendrocyte precursor cells (OPCs) may be used to treat contusive spinal cord injury (SCC), and alter microRNA (miRNA/miR) expression following SCC in rats. However, the association between miRNA treatment of rats with OPC transplantation remain unclear. The present study transplanted OPCs into subsequently Basso, Beattie Bresnahan (BBB) score assess functional recovery pain scores. An assay was performed detect differentially expressed miRNAs OPCs, compared...
Cichoric acid extract (CAE) from Echinacea purpurea L. was used to investigate the anti-arthritic effect by using collagen-induced arthritis (CIA) rat model. The hind paw swelling volume and body weight were measured recorded. All drug solutions administered orally rats for a total of 28 days. On day 28, anaesthetized decapitated. thymus spleen weighed determination organ index. concentration tumor necrosis factor alpha (TNFα), interleukin-1 beta (IL-1β) prostaglandin E2 (PGE-2) in serum...
Abstract Our previous study found that Ganoderma lucidum polysaccharide (GLP), bioactive ingredients from , protected fibroblasts photoaging. However, whether GLP can affect melanogenesis in melanocytes through regulating paracrine mediators secreted by keratinocytes and is unclear. We aimed to investigate the efficacy mechanisms of action effects fibroblasts. The effect on cell viability affected was measured 3‐(4,5‐dimethyl‐2‐thiazolyl)‐2,5‐diphenyl‐2H‐tetrazolium bromide (MTT) assay....
Keratinocytes regulate melanogenesis in a paracrine manner. Previous studies have shown that melatonin can directly inhibit melanin production the melanocytes. However, it is unclear whether also indirectly through keratinocytes. In this study, we explored role of regulating keratinocyte-mediated using reconstructed human epidermis (RHE). Melatonin showed an inhibitory effect on synthesis model. Furthermore, conditioned media from melatonin-treated HaCaT cells downregulated...
Atopic dermatitis, a common chronic inflammatory skin disease, has an unclear etiology and may involve multiple factors such as genetic predisposition, immune abnormalities, impaired barrier function. Currently, there is no specific medication available for the complete cure of atopic dermatitis. The current treatment approaches mainly focus on symptom relief control rather than curative treatment. Some commonly used medications topical corticosteroids immunosuppressants, have certain...
Abstract Background: The patient suffering from urinary sepsis is often accompanied by elevated serum procalcitonin (PCT) levels and a decline in the average platelet count (PLT), which could result poor prognosis. This study aimed to evaluate value of PCT PLT determining severity sepsis. Methods: A total 120 urosepsis patients enrolled were divided into survival group death group, respectively, according their status within 14 days after admission. Changes between 2 groups compared at...
Ultraviolet (UV) radiation is the primary exogenous inducer of skin pigmentation, although mechanism has not been fully elucidated. N6-methyladenosine (m6 A) modification one key epigenetic form gene regulation that affects multiple biological processes. The aim this study was to explore role and underlying mechanisms m6 A in UVB-induced melanogenesis. Low-dose UVB increased global melanocytes (MCs) MNT1 melanoma cell line. GEPIA database predicted methyltransferase METTL3 positively...