A5100754572- melanin and skin pigmentation
- Cancer-related molecular mechanisms research
- Skin Protection and Aging
- Psoriasis: Treatment and Pathogenesis
- RNA regulation and disease
- RNA modifications and cancer
- Acne and Rosacea Treatments and Effects
- Medical and Biological Ozone Research
- Ultrasound and Hyperthermia Applications
- Heat shock proteins research
- Olfactory and Sensory Function Studies
- Phytochemicals and Antioxidant Activities
- Sphingolipid Metabolism and Signaling
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Retinoids in leukemia and cellular processes
- Photoacoustic and Ultrasonic Imaging
- Telomeres, Telomerase, and Senescence
- Genomics and Chromatin Dynamics
- Rheumatoid Arthritis Research and Therapies
- Hormonal Regulation and Hypertension
- Biological Activity of Diterpenoids and Biflavonoids
- Cancer-related gene regulation
- Herpesvirus Infections and Treatments
- Thermoregulation and physiological responses
- Dermatology and Skin Diseases
Third Xiangya Hospital
2016-2025
Central South University
2016-2025
Chongqing Medical University
2022
Xiangya Hospital Central South University
2017-2021
Shanghai East Hospital
2013-2014
Yale University
2003
Psoriasis is a common and chronic inflammatory skin disease that complicated by gene-environment interactions. Although genomic, transcriptomic, proteomic analyses have been performed to investigate the pathogenesis of psoriasis, role metabolites in particularly lipids, remains unclear. Lipids not only comprise bulk cellular membrane bilayers but also regulate variety biological processes such as cell proliferation, apoptosis, immunity, angiogenesis, inflammation. In this study, an...
Abstract Keratinocytes are closely associated with innate immunity and inflammatory responses, dysregulated during the development of psoriasis, but underlying mechanisms not yet fully understood. This work aims to reveal effects long non-coding RNA (lncRNA) UCA1 in psoriatic keratinocytes. was identified as a psoriasis-related lncRNA that highly expressed lesions. The transcriptome proteome data keratinocyte cell line HaCaT showed could positively regulate functions, such response cytokine....
Ganoderma lucidum has featured in traditional Chinese medicine for >1,000 years. polysaccharides (GL-PS), a major active ingredient Ganoderma, confer immune regulation, antitumor effects and significant antioxidant effects. The aim of the present study was to investigate efficacy mechanism GL‑PS‑associated inhibition ultraviolet B (UVB)‑induced photoaging human fibroblasts vitro. Primary skin were cultured, fibroblast model built through exposure UVB. Cell viability measured by MTT assay....
Ozone therapy has been widely used to treat many skin diseases, including infections, allergic dermatosis, and ulcers.However, its efficacy as a treatment for psoriasis is unclear.In this study, we explored the clinical underlying molecular mechanisms of ozone on psoriasis.We found that topical significantly decreased patients' area severity index (PASI) scores expression psoriasis-associated cytokines in their peripheral blood CD4 + T cells.In IMQ-induced mouse model, inhibited formation...
Abstract Psoriasis is a chronic immune‐mediated inflammatory dermatosis. Recently, ozone therapy has been applicated to psoriasis treatment; however, the mechanism by which improves remains unclear. The excessive proliferation and differentiation of basal keratinocytes have considered critical issues during pathological process, in keratin 6 (KRT6) KRT10 might be involved. In present study, KRT6, IL‐17 IL‐22 protein within lesions was decreased, while Tp63 increased treatment both patient...
Ultraviolet (UV) radiation is the primary exogenous inducer of skin pigmentation, although mechanism has not been fully elucidated. N6-methyladenosine (m6 A) modification one key epigenetic form gene regulation that affects multiple biological processes. The aim this study was to explore role and underlying mechanisms m6 A in UVB-induced melanogenesis. Low-dose UVB increased global melanocytes (MCs) MNT1 melanoma cell line. GEPIA database predicted methyltransferase METTL3 positively...
Psoriasis is a common immune-mediated, chronic inflammatory genetic-related disease that affects patients’ quality of life. Myeloid-derived suppressor cells (MDSCs) are heterogeneous population progenitor and immature myeloid which expanded in psoriatic skin lesions peripheral blood. However, the role MDSCs pathogenesis psoriasis remains unclear. Here, we confirmed accumulation human remarkably increased patients by flow cytometry. Depleting Gemcitabine significantly suppresses IMQ-induced...
α-MSH is known for melanogenesis stimulation, and ceRNA a new method involved in physiological regulation. However, whether participates α-MSH-induced remains unknown. We used array to detect the expression profiles of lncRNAs, circRNAs, mRNAs melanocytes after treatment. Moreover, melanogenesis-related regulatory networks were screened validated. The profile analysis showed that 20 lncRNAs 49 circRNAs changed five-fold treatment, while 933 two-fold. Based on differentially expressed genes,...
Abstract The long noncoding RNA H19 was reported to associate with melanogenesis. However, it remains unknown whether expression will be changed by UVB irradiation and regulate melanocytes melanogenesis paracrine effects. Here, we analysed the changes of irradiated in keratinocytes explored mechanism stimulated through First, after were exposed irradiation, pro‐opiomelanocortin ( POMC ) measured qRT ‐ PCR . Also, α‐melanocyte‐stimulating hormone (α‐ MSH contents cells supernatant ELISA Then,...
Little is known about the use of antioxidants in clinical treatment vitiligo. To investigate specific vitiligo and possible reasons behind its China, we conducted a prospective questionnaire-based study using an online questionnaire comprising 26 questions 5 areas. A total 323 frontline dermatologists participated this study. Differences among groups were compared Pearson's chi-square test. Ordinal logistic regression was used to develop knowledge-use multiple models. Among dermatologists,...
Melanoma accounts for nearly 80% of all deaths associated with skin cancer.CD147 plays a very important role in melanoma progression and the expression level may correlate tumor malignancy. RING1 can bind DNA act as transcriptional repressor, play an aggressive phenotype melanoma. The interactions between CD147 were identified yeast two-hybrid interacted through transmembrane domain. inhibits CD147's capability promoting cell migration. In conclusion, study novel RING1, recovered nuclear...
Psoriasis is a common inflammatory skin disease that seriously affects the patient's quality of life. The diagnosis psoriasis mainly based on clinical and pathological features, assessment depends area severity index (PASI). However, there are few reliable accurate evaluation methods to assess lesion therapeutic effects. This work identified 17 model genes from GEO datasets established 6 models by LASSO regression, linear random forest separately. Models were trained evaluated in different...
Ultrasound, a non-invasive therapy method, is potential tool for medical applications, but its biological effects on vascular smooth muscle cells (VSMCs) have not been characterized.The aim of this study was to explore the effect and possible apoptotic mechanism VSMCs that were induced by low-frequency ultrasound (LFU).Cell viability apoptosis A7r5 evaluated after treating with continuous 45-kHz 1.0-W/cm 2 (exposure time 0, 10, 20, 30, 35 s) MTT assay flow cytometry.At optimum exposure...
In China, there is a lack of data regarding the awareness and treatment preferences among patients with vitiligo their families. To address this gap, cross-sectional questionnaire-based study was conducted to investigate disease in Chinese vitiligo. The also evaluated willingness pay, using 2 standardized items, assessed quality life, Dermatology Life Quality Index (DLQI) score. Data from 307 (59.3% women, mean age 28.98 years, range 2-73 years) were analysed. Of these patients, 44.7% had...
We investigated in vitro the effect of low-frequency and low-energy ultrasound (LFLEU) on apoptosis an overexpressed HSP27 human aortic smooth muscle cell (HASMC) line.A frequency 42.6 kHz was used all experiments.HASMC were exposed to viability evaluated by MTT reduction.Overexpressed HSP27-HASMC constructed a pcDNA3.1 vector.Apoptosis determined 24 h after treatment flow cytometry; gene display with Affimax chips, mRNA protein expression levels measured RT-PCR Western blotting.The rate (at...
For herpes zoster (HZ) infection, early diagnosis and treatment are important in order to shorten the course of disease reduce sequelae, however, there is a lack non-invasive diagnostic methods. Reflectance confocal microscopy (RCM) technique often used diagnose dyspigmented dermatosis, skin tumours, human papillomavirus infectious etc. To evaluate clinical value RCM for HZ. We collected images from 30 HZ patients with typical vesicles analyse their features. then utilized lesions another 12...
Abstract Psoriatic inflammation can be regulated by epigenetic factors, but little is known about their role. This work aims to reveal the effects of lncRNA UCA1 in keratinocyte inflammation. was a psoriasis-related eight GEO transcriptome datasets and psoriatic skin. When we over-expressed or knocked down cell line (HaCaT), proteomic data showed that could positively regulate inflammatory functions, such as response cytokine. Experimental findings confirmed increase cytokine secretion,...
In non-sun exposure conditions, skin pigmentation gradually decreases with age. Sun on the other hand increases pigmentation. addition, of elderly is more prone to tanning than youthful skin.