A5101840834- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Psoriasis: Treatment and Pathogenesis
- Cutaneous Melanoma Detection and Management
- Nonmelanoma Skin Cancer Studies
- Cutaneous lymphoproliferative disorders research
- Systemic Lupus Erythematosus Research
- MicroRNA in disease regulation
- T-cell and B-cell Immunology
- Dermatologic Treatments and Research
- Cancer-related molecular mechanisms research
- Medical and Biological Ozone Research
- Vitamin D Research Studies
- Skin Protection and Aging
- Urticaria and Related Conditions
- Sympathectomy and Hyperhidrosis Treatments
- RNA modifications and cancer
- Air Quality and Health Impacts
- Retinoids in leukemia and cellular processes
- Escherichia coli research studies
- Kruppel-like factors research
- Toxoplasma gondii Research Studies
- Therapeutic Uses of Natural Elements
- Dermatological and Skeletal Disorders
- Circular RNAs in diseases
Third Xiangya Hospital
2016-2024
Central South University
2012-2024
Huaian First People’s Hospital
2024
Nanjing Medical University
2024
Second Xiangya Hospital of Central South University
2011-2012
Zen-Noh (Japan)
2000
Abstract Objective To examine the role of microRNA‐142‐3p/5p (miR‐142‐3p/5p) in development autoimmunity patients with systemic lupus erythematosus (SLE). Methods MicroRNA‐142‐3p/5p expression levels were determined by real‐time quantitative polymerase chain reaction, and potential target genes verified using luciferase reporter gene assays. The effects miR‐142‐3p/5p on T cell function assessed transfection inhibitors or mimics. Histone modifications methylation within a putative regulatory...
Staphylococcus aureus (S. aureus) accounts for 90% of the microbiome in atopic dermatitis (AD) lesions and plays a role disease flare-ups worsens outcome. Ozone treatment can improve AD conditions by its bactericidal effect on S. aureus.To study effects topical ozone therapy diversity explore potential probiotic pathogens correlated with progression.Patients moderate to severe bilateral skin were recruited. Randomized split sides performed. One side was treated hydrotherapy followed ozonated...
Ganoderma lucidum has featured in traditional Chinese medicine for >1,000 years. polysaccharides (GL-PS), a major active ingredient Ganoderma, confer immune regulation, antitumor effects and significant antioxidant effects. The aim of the present study was to investigate efficacy mechanism GL‑PS‑associated inhibition ultraviolet B (UVB)‑induced photoaging human fibroblasts vitro. Primary skin were cultured, fibroblast model built through exposure UVB. Cell viability measured by MTT assay....
Long non-coding RNA (lncRNA), transcripts of >200 bp in length that do not appear to exhibit any coding capacity, are important the occurrence and development cancer, cardiovascular neurological diseases. However, effects lncRNAs on photo‑aging remain be elucidated. To explore potential lncRNA metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1) fibroblasts, MALAT1 expression was silenced fibroblasts using small interference RNA. Reverse transcription‑quantitative polymerase chain...
The reduced expression of miR-142-3p/5p in CD4+ T cells SLE patients caused cell hyperactivity and B hyperstimulation. This study aimed to investigate the mechanisms regulating cells. BCL-6 was significantly increased compared with normal controls, inversely correlated expression. suppresses by increasing H3K27me3 level reducing H3K9/K14ac levels regulates histone modifications miR-142 promoter recruiting EZH2 HDAC5. Furthermore, we observed decreased CD40L, ICOS, IL-21 interference,...
The increased BAFF expression in B-cells of patients with systemic lupus erythematosus (SLE) is associated B-cell hyperstimulation and T-cell hyperactivity, but the underlying mechanisms are still unclear. This study aimed to uncover that regulate SLE B-cells. results demonstrated miR-152-3p was significantly compared normal controls. confirmed Kruppel-like factor 5 (KLF5) a direct target miR-152-3p, it could bind promoter region inhibit its upregulation miRNA-152-3p decreased KLF5 Knockdown...
Abstract Psoriasis is a chronic immune‐mediated inflammatory dermatosis. Recently, ozone therapy has been applicated to psoriasis treatment; however, the mechanism by which improves remains unclear. The excessive proliferation and differentiation of basal keratinocytes have considered critical issues during pathological process, in keratin 6 (KRT6) KRT10 might be involved. In present study, KRT6, IL‐17 IL‐22 protein within lesions was decreased, while Tp63 increased treatment both patient...
Photoageing is attributed to continuous sunlight or artificial ultraviolet exposure and manifests as clinical histological changes in skin. Epigenetic have been found be involved the pathogenesis of photoageing. However, underlying mechanisms are unclear.To analyse histone modification patterns sun-exposed nonexposed skin, identify abnormally histone-modified genes related photoageing.Skin biopsies were collected from both outer forearm (sun-exposed area) buttock (sun-protected 20 healthy...
Up-regulated cyclic adenosine 5'-monophosphate response element modulator α (CREMα) which can inhibit IL-2 and induce IL-17A in T cells plays a critical role the pathogenesis of systemic lupus erythematosus (SLE). This research aimed to investigate mechanisms regulating CREMα expression SLE. From chromatin immunoprecipitation (ChIP) microarray data, we found sharply increased H3 lysine 4 trimethylation (H3K4me3) amount at promoter SLE CD4+ compared controls. Then, by ChIP real-time PCR,...
Background Keratinocytes of psoriasis have anti-apoptotic properties including delayed apoptosis process, accelerated proliferation metabolism and postponed differentiation process. However, the specific mechanism leading to abnormal biological behavior keratinocytes remains unclear. Objectives We investigated role increased RPL22 expression in regulating regulation skin lesions psoriatic patients. Methods examined clinical samples utilized cytokine-induced cell IMQ-treated mouse models....
DNA hydroxymethylation refers to a chemical modification process in which 5-methylcytosine (5mC) is catalyzed 5- hydroxymethylcytosine (5hmC) by ten-eleven translocation (TET) family proteins. Recent studies have revealed that aberrant TETs expression or 5hmC level may play important roles the occurrence and development of various pathological physiological processes including cancer aging. This study aimed explore relation between with skin photoaging investigate levels TETs, 5mC, 24 h...
Axillary osmidrosis (AO) is a common disease that causes patients to develop malodor and occurs worldwide. There lack of uniform standards evaluate the severity odor identify sensitive convenient method determine therapeutic effect AO treatments in clinical setting. In present study, association between pH value was investigated potential pathogenic bacteria probiotic pathogens were further examined. A total 32 with bilateral normal healthy controls recruited for study. The using traditional...
Bullous pemphigoid is a blistering autoimmune disease characterized by two hemidesmosomal proteins (anti-BP180 and 230). Pemphigus, contrast, autoantibodies (anti-desmoglein 1 3). Coexistence of bullous pemphigus in patient rare. A 25-year-old male was admitted to our hospital, reporting 3-month history multiple papules, vesicles, erosions over an extensive erythema on the entire body. Laboratory tests showed high levels serum IgE, anti-BP180 antibodies, anti-desmoglein 3. Histopathologic...
Background Allergic rhinitis (AR) and chronic spontaneous urticaria (CSU) are often concurrent in patients. Changes DNA methylation affect T cell biological processes, which may explain the occurrence progression of comorbidity. However, downstream regulatory pathways two diseases underlying mechanisms have not been fully elucidated. Methods The GSE50101, GSE72541, GSE50222 OEP002482 were mined for identification differentially expressed genes (DEGs) or co-expressed methylated (DMGs) AR CSU...
Abstract Objective To investigate the application and challenge of reflectance confocal microscopy (RCM) in diagnosis pigmented nevus. Method A total 997 patients with clinical nevus were included study, RCM imaging was performed on lesion each patient. biopsy 78 these for histological diagnosis. We retrospectively analyzed results then found characteristics histologically confirmed lesion. Results According to images, 823 (82.55%) diagnosed nevus, while 113 (11.33%) not by dermatologists...
Abstract Bowen's disease (BD) is a relatively rare early‐stage squamous cell carcinoma in situ, most commonly affecting the middle‐aged and elderly, occurring on skin or mucous membranes of various parts body. Its onset concealed, course chronic, some patients have malignant tumors outside skin; therefore, it necessary to diagnose evaluate at an early stage. This study aimed investigate application reflectance confocal microscopy (RCM) diagnosis BD. We performed RCM imaging lesion site...
This study investigated the mechanism and efficacy of topical acidified aliphatic ester for treatment axillary osmidrosis (AO). A total 32 AO patients were enrolled in this study. In initial pilot study, 20 double-blindly, randomly divided into or groups, followed by evaluation after 4 weeks. Then, all (n = 32) treated with 16 Efficacy was evaluated at every weeks, 3- 6-month follow-ups. Changes pH values microecology targeting sites analyzed. first cohort 20) showed significantly higher...
Bowen’s disease (BD) is a relatively rare early-stage squamous cell carcinoma in situ, most commonly affecting the middle-aged and elderly, occurring on skin or mucous membranes of various parts body. Its onset concealed, course chronic, some patients are accompanied by malignant tumors outside skin, so it necessary to diagnose evaluate its early stage. This study aims investigate application reflectance confocal microscopy (RCM) diagnosing disease. We performed RCM imaging lesion site 113...