A5112894528- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Cancer Mechanisms and Therapy
- Drug-Induced Hepatotoxicity and Protection
- Nanoplatforms for cancer theranostics
- Gut microbiota and health
- Immune cells in cancer
- Phytochemistry and Bioactivity Studies
- Ferroptosis and cancer prognosis
- Hepatitis B Virus Studies
- Ginseng Biological Effects and Applications
- Cancer Immunotherapy and Biomarkers
- Pharmacological Effects of Natural Compounds
- Inflammasome and immune disorders
- Angiogenesis and VEGF in Cancer
- Advanced Nanomaterials in Catalysis
- Medical Research and Treatments
- Metal-Organic Frameworks: Synthesis and Applications
- Physiological and biochemical adaptations
- Diet, Metabolism, and Disease
- Phytochemistry and Bioactive Compounds
- Circular RNAs in diseases
- Erythrocyte Function and Pathophysiology
- Hepatitis Viruses Studies and Epidemiology
- Kruppel-like factors research
Beijing YouAn Hospital
2021-2025
Capital Medical University
2021-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Guang’anmen Hospital
2020-2025
University of Louisville
2024
Sun Yat-sen University
2019-2023
Beijing Fengtai Hospital
2023
The First Affiliated Hospital, Sun Yat-sen University
2019-2023
China Academy of Chinese Medical Sciences
2020-2022
Immunotherapy, particularly αPD-1 therapy, has been hailed as a significant breakthrough in cancer treatment. However, the limited response rates and unknown mechanisms hinder clinical application of blockade boosting with hybrid nanoparticles. Herein, we introduce strategy to enhance immunotherapy by leveraging cuproptosis, initiated spiky copper-based metal-organic framework (S@Cu-MOF) loaded polyphyllin I (PPI) synergized therapy. Interestingly, unique structure S@Cu-MOF not only...
Abstract Circular RNAs (circRNAs) are known to act as key regulators in a variety of malignancies. However, the role circRNAs cervical cancer (CCa) remains largely unknown. Herein, we demonstrated that circRNA derived from TADA2A gene (hsa_circ_0043280) was significantly downregulated CCa and this reduction expression correlated with poor prognosis. Furthermore, our results hsa_circ_0043280 functions tumor suppressor inhibit growth metastasis CCa. Mechanistically, competitively sponges...
Immunotherapy has revolutionized the landscape in clinical tumor therapy, although response rates "cold" tumors are relatively low owing to complex microenvironment (TME). Cyclic guanosine monophosphate-adenosine monophosphate synthase/stimulator of interferon genes (cGAS/STING) pathway-inducing agents can reprogram TME; however, their applications remain underutilized. Herein, we engineered a facile manganese-based metal-organic framework (Mn-MOF) encapsulating polyphyllin I (PPI) and...
Silibinin-phospholipid complex (SPC) has been utilized to treat acute liver injury clinically. Nevertheless, the hepatoprotective mechanism of SPC remains be further dissected in response new insights into pathogenesis injury. Very recently, we have documented, for first time, that M2-like macrophages exert hepatoprotection against insult through inhibiting necroptosis-S100A9-necroinflammation. In present work, integrated this finding action SPC, and attempted dissect from perspective.SPC...
Cervical cancer remains a significant health issue in developing countries. However, finding preclinical model that accurately reproduces tumor characteristics is challenging. Therefore, we established patient-derived organoids (PDOs) biobank containing 67 cases of heterogeneous cervical mimic the histopathological and genomic parental tumors. The vitro response indicated their ability to capture radiological heterogeneity patients. To individual responses adoptive T cell therapy (ACT),...
Bergenin is a secondary metabolite that may be primarily isolated from Bergenia species. Although it has been found to exhibit significant biological activities, the anticancer activity of bergenin against cervical cancer cells not explored. The present study was designed evaluate effects on HeLa cells. results showed reduced cell viability in dose‑dependent pattern. However, were comparatively lower normal Furthermore, due induction apoptosis Notably, also enhanced expression Bax and...
Abstract Background There is growing recognition of natural history, complications, and outcomes patients who develop non-acetaminophen (APAP) drug-induced acute liver failure (ALF). To clarify high-risk factors a nomogram model to predict transplant-free survival (TFS) in with non-APAP ALF. Methods Patients ALF from 5 participating centers were retrospectively analyzed. The primary endpoint was 21-day TFS. Total sample size 482 patients. Results Regarding causative agents, the most common...
Sanhuang Xiexin Decoction (SXD) is commonly used to treat type 2 diabetes mellitus (T2DM) in clinical practice of traditional Chinese medicine (TCM). In order elucidate the specific analysis mechanisms SXD for T2DM, method network pharmacology was applied this article. First, effective ingredients were obtained and their targets identified based on TCMSP database. The T2DM‐related screened from GEO database also collected by comparing differential expressed genes between T2DM patients...
Background: Depression is a burdensome psychiatric disorder presenting with disordered inflammation and neural plasticity. We conducted this study an aim to explore the effect of stanniocalcin-1 (STC1) on neuron injury in rats depression-like behaviors. Methods: A model behaviors was established Wistar by stress stimulation. Adeno-associated virus (AAV)-packaged STC1 overexpression sequence or siRNA against introduced into enhance silence expression. Moreover, we measured pro-inflammatory...
Abstract Background Kaixin Jieyu Granule (KJG), an improved formula of Kai-xin-san and Si-ni-san, is a highly effective with demonstrated efficacy in preventing depression previous studies. However, the underlying molecular mechanisms KJG’s antidepressant effects on inflammatory molecules remain unclear. This study aimed to explore therapeutic KJG using network pharmacology experimental validation. Methods We employed multi-faceted approach, combining high-performance liquid chromatography...
Inhomogeneous magnetic field is introduced into pulsed laser deposition process, in order to find new properties of diamond-like carbon film grown under field, thereby offering the theoretical and experimental basis for further enhancing sp<sup>3</sup>-bond content this film. Distribution strength flux lines induced by a rectangular permanent magnet calculated. And then, flying trace ions also simulated iterative method, which indicates that cannot expand freely they are confined...
A novel class of agents is developed based on the core engineering open-shelled organic mixed-valence (MV) systems, which enable tunable absorption and emission across near infrared (NIR)-I to III biowindow (700-1850 nm) by adjusting number central nitrogen oxidation sites length conjugated bridge. Organic systems are synthesized through a one-step partial chemical starburst oligoarylamines, with varying bridge lengths, including tris(4-[diethylamino]phenyl)aminen+ (T4EPAn+ ),...
Immune checkpoint inhibitors (ICIs) have emerged as effective therapeutics for multiple cancers. Nevertheless, immunotherapeutic approaches are being extensively utilized, substantial hurdles arisen clinicians. These include countering ICIs resistance and ensuring precise efficacy assessments of these drugs, especially in the context hepatocellular carcinoma (HCC). This review attempts to offer a holistic overview latest insights into mechanisms HCC, molecular underpinnings, immune response....
Abstract Background The manifestations and prognoses of acute-on-chronic liver failure (ACLF) with different precipitating events remain heterogeneous. We aimed to investigate the characteristics prognosis patients hepatotropic viral insult (HVI)-induced hepatitis B-related ACLF (HBV-ACLF). Methods 452 confirmed diagnosis were screened in three medical centers China, 203 HBV-ACLF definite acute retrospectively analyzed. According events, induced by HBV reactivation super-infection HAV...
Following the publication of above paper, a concerned reader drew to Editor’s attention that, in Fig. 6, data panels shown for experiments performed with 7.5, 15 and 30 μM bergenin were strikingly similar terms their overall appearance. Furthermore, several figures contained that bore striking similarities published other papers; notably, cellular 3 appeared have been presented different field view 2 another paper written by authors based at research institution [Zeng C, Guo B, Chen J He W:...
Background: Intestine epithelial hypoxia-inducible factor-1α (HIF-1α) plays a critical role in maintaining gut barrier function. The aim of this study was to determine whether pharmacological or genetic activation intestinal HIF-1α ameliorates western diet–induced metabolic dysfunction–associated steatotic liver disease. Methods: Metabolic effects by dimethyloxalylglycine were evaluated HIF-α luciferase reporter (ODD-luc) mice. Male and/or female epithelial–specific Hif1α overexpression mice...
Abstract Gastric cancer is a highly prevalent type of among digestive system tumors. Early screening and intervention gastric can significantly improve the prognosis patients. This paper aims to explore driver genes associated with gastritis-gastric progression therapeutic role Chinese medicine based on bioinformatics analysis microarray data. First, dataset GSE55696 gastritis was downloaded from GEO database. The weighted gene co-expression network used identify modules cancer. And...
Objective: To analyze the clinical characteristics among types of acute-on-chronic liver failure (ACLF) and explore new classification criteria for judging prognosis failure, so as to provide a basis formulation more precise therapeutic schedule. Methods: 388 cases with ACLF diagnosed in two tertiary level hospitals were included. Patients demographic characteristics, examination information, diagnostic treatment process information collected. Laboratory data day 1, 3, 7, 14, 21, 28 week 12...
Abstract Background: Most cases of gastric cancer (GC), which is one the most common cancers in China, are diagnosed at an advanced stage. The first-line treatments for GC include 5-fluoropyrimidine (5-FU)-based chemotherapy. However, cells may develop 5-FU resistance. inhibition angiogenesis can be alternative therapeutic strategy GC. Recent studies have demonstrated that TIE2-expressing monocytes/macrophages (TEMs), a subtype tumor-associated macrophages (TAMs), exhibit profound...