A5100394842- melanin and skin pigmentation
- Skin Protection and Aging
- Cancer-related molecular mechanisms research
- RNA regulation and disease
- Biochemical Analysis and Sensing Techniques
- Hippo pathway signaling and YAP/TAZ
- Phytochemicals and Antioxidant Activities
- Dermatology and Skin Diseases
- Olfactory and Sensory Function Studies
- Psoriasis: Treatment and Pathogenesis
- Spinal Fractures and Fixation Techniques
- Microtubule and mitosis dynamics
- RNA Research and Splicing
- Spine and Intervertebral Disc Pathology
- Fungal Biology and Applications
- Skin and Cellular Biology Research
- Nonmelanoma Skin Cancer Studies
- Acne and Rosacea Treatments and Effects
- Reconstructive Surgery and Microvascular Techniques
- Infectious Diseases and Tuberculosis
- Orthopedic Infections and Treatments
- Cancer-related gene regulation
- Cellular transport and secretion
- Scoliosis diagnosis and treatment
- Epigenetics and DNA Methylation
Northeast Normal University
2025
Central South University
2015-2024
Fujian Medical University
2024
Union Hospital
2024
Third Xiangya Hospital
2013-2024
Lifenet Health
2024
Lanzhou University
2024
Xiangya Hospital Central South University
2007-2023
Virginia Tech
2022
Shanghai University of Traditional Chinese Medicine
2022
Abstract Background Chemotherapy resistance is a primary reason of ovarian cancer therapy failure; hence it important to investigate the underlying mechanisms chemotherapy and develop novel potential therapeutic targets. Methods RNA sequencing cisplatin‐resistant ‐sensitive (chemoresistant chemosensitive, respectively) organoids was performed, followed by detection expression level fibrillin‐1 (FBN1) in clinical specimens cancer. Subsequently, glucose metabolism, angiogenesis,...
Abstract Ultraviolet (UV)‐induced pigmentation is very common in clinical practice, but the current treatments are rarely effective, accompanied by some side effects. Ganoderma lucidum polysaccharide (GLP) a natural antioxidant with no toxic effects, which can antagonize UVB‐induced fibroblast photo aging. The study aims to explore role of GLP inhibiting melanogenesis and its possible mechanism. expression genes such as microphthalmia‐associated transcription factor (MITF), tyrosine (TYR),...
Background Psoriasis is one of the most frequent inflammatory skin conditions and could be treated via tele-dermatology, provided that current lack reliable tools for objective severity assessments overcome. Area Severity Index (PASI) has a prominent level subjectivity rarely used in real practice, although it widely accepted metric measuring psoriasis currently. Objective This study aimed to develop an image–artificial intelligence (AI)–based validated system assessment with explicit...
Fused Toes (FTS) is a member of small group inactive variant E2 ubiquitin-conjugating enzyme domain-containing proteins unknown function. Through proteomic analysis FTS complexes purified from human embryonic kidney 293T cells, we identified new multiprotein complex, the FHF containing FTS, members microtubule-binding Hook family coiled-coil (Hook1, Hook2, and Hook3), previously uncharacterized 107-kDa protein, Interacting Protein (FHIP). associated with conserved C-terminal motif in yeast...
Staphylococcus aureus (S. aureus) accounts for 90% of the microbiome in atopic dermatitis (AD) lesions and plays a role disease flare-ups worsens outcome. Ozone treatment can improve AD conditions by its bactericidal effect on S. aureus.To study effects topical ozone therapy diversity explore potential probiotic pathogens correlated with progression.Patients moderate to severe bilateral skin were recruited. Randomized split sides performed. One side was treated hydrotherapy followed ozonated...
Abstract Cancer or endothelial cells preferably catabolize glucose through aerobic glycolysis rather than oxidative phosphorylation. Intracellular ionic signaling has been shown to regulate metabolism, but the underlying ion channel yet be identified. RNA-seq, metabolomics and genetic assay revealed that TRPM7 regulated cellular glycolysis. Deletion of suppressed cancer cell reduced xenograft tumor burden. Deficiency inhibited postnatal retinal angiogenesis in mice. Mechanistically,...
ObjectiveWe assessed the efficacy and safety of duloxetine (60 mg, once daily), compared with placebo, during a 13-week treatment period in Chinese patients chronic pain due to osteoarthritis (OA).DesignPatients were at least 40 years old (male or female) who met American College Rheumatology clinical radiographic criteria for diagnosis OA knee hip. The primary measure this phase 3, randomized, double-blind, placebo-controlled trial was assessment severity by Brief Pain Inventory (BPI) 24-h...
Ganoderma lucidum has featured in traditional Chinese medicine for >1,000 years. polysaccharides (GL-PS), a major active ingredient Ganoderma, confer immune regulation, antitumor effects and significant antioxidant effects. The aim of the present study was to investigate efficacy mechanism GL‑PS‑associated inhibition ultraviolet B (UVB)‑induced photoaging human fibroblasts vitro. Primary skin were cultured, fibroblast model built through exposure UVB. Cell viability measured by MTT assay....
Abstract As a main part of pigmentation disorders, skin depigmentation diseases such as vitiligo and achromic naevus are very common get more attention now. The pathogenesis includes melanocyte dysfunction loss, which possibly caused by heredity, autoimmunity oxidative stress. Among them, stress plays key role; however, few clinical treatments can deal with reported, Cistanche deserticola polysaccharide (CDP) is an effective antioxidant; based on that, we evaluated its role in further...
Pleurotus pulmonarius (Fr.) is an edible and medicinal fungus. Here, we isolated polysaccharides from P. evaluated their physicochemical properties, anti-tumor activity, gut microbiota regulation. Freeze-dried powder of fruiting body polysaccharide (PFP) a heteropolysaccharide, mainly composed galactose (295.52 μg/mg). PFP significantly inhibited glioma cell survival in vitro U251 tumor growth nude mice (inhibition rate, 53.70%). YAP1 TAZ protein expression levels, upregulated those MST1...
Background: This study analyzes the biomechanical contributions of non-throwing arm during completion phase glide shot put technique, focusing on its roles in performance optimization. Methods: Data from a Chinese elite female shot-putter were collected national championship, with three-dimensional kinematic analyses and Spearman correlation to assess joint displacement, velocity, angular changes. Results: Distal joints exhibited greater displacement but lower peak velocity than proximal...
Introduction: Previous observational studies have shown an association between specific dietary intake and atopic diseases. However, few analyzed the causal effects of factors on risk Therefore, we conducted a Mendelian randomization (MR) study to explore these relationships. Methods: In this study, obtained summary statistics diseases including dermatitis, allergic asthma, conjunctivitis, rhinitis from large genome‐wide (GWASs) in European populations. MR analysis was performed using...
A retrospective clinical study of 1-stage surgical management for multilevel tuberculous spondylitis the upper thoracic region (MTSUTR).MTSUTR has rarely been documented in literature. We present a 23 patients with MTSUTR treated by anterior decompression, strut autografting, posterior instrumentation, and fusion. The purpose was to determine efficacy such treatment MTSUTR.It is considered safe effective treat surgically local spinal cord compression. Many reports have good tuberculosis....
Prostate cancer is the second-deadliest in men United States, seriously affecting people's life and health. The Gleason grading system one of most reliable methods to quantify invasiveness prostate cancer, which great significance for risk assessment treatment planning patients. However, task automating difficult because complexity pathological images cancer. This paper presents an automated pattern region segmentation method based on deep learning An architecture combining atrous spatial...
Most prostate cancer (PCa) deaths result from progressive failure in standard androgen deprivation therapy (ADT), leading to metastatic castration-resistant PCa (mCRPC); however, the mechanism and key players this are not fully understood. While studying role of tousled-like kinase 1 (TLK1) never mitosis gene A (NIMA)-related (NEK1) a DNA damage response (DDR)-mediated cell cycle arrest LNCaP cells treated with bicalutamide, we uncovered that overexpression wt-NEK1 resulted rapid conversion...