A5064360081- Anesthesia and Neurotoxicity Research
- Pain Mechanisms and Treatments
- Intensive Care Unit Cognitive Disorders
- Neuroscience and Neuropharmacology Research
- Biochemical effects in animals
- Stress Responses and Cortisol
- Sirtuins and Resveratrol in Medicine
- Anesthesia and Sedative Agents
- High-Temperature Coating Behaviors
- Immune Response and Inflammation
- Neuropeptides and Animal Physiology
- High Entropy Alloys Studies
- Advanced materials and composites
- Apelin-related biomedical research
- Neuroendocrine regulation and behavior
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Asthma and respiratory diseases
- Pharmacological Effects of Natural Compounds
- Hormonal Regulation and Hypertension
- Cancer, Stress, Anesthesia, and Immune Response
- Systemic Lupus Erythematosus Research
- Epigenetics and DNA Methylation
- Insect and Pesticide Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Phytochemicals and Antioxidant Activities
Xuzhou Medical College
2013-2025
Capital Medical University
2024
Tianjin International Joint Academy of Biomedicine
2024
Eye & ENT Hospital of Fudan University
2024
Shanghai Eye Disease Prevention & Treatment Center
2024
Children's Hospital of Fudan University
2024
Nanjing Medical University
2005-2023
Nanjing Brain Hospital
2022-2023
Yangzhou University
2004-2021
Central South University
2020
Abstract Background Postoperative cognitive dysfunction (POCD) is a very common complication that might increase the morbidity and mortality of elderly patients after surgery. However, mechanism POCD remains largely unknown. The NAD-dependent deacetylase protein Sirtuin 3 (SIRT3) located in mitochondria regulates mitochondrial function. SIRT3 only sirtuin specifically plays role extending lifespan humans associated with neurodegenerative diseases. Therefore, aim this study was to evaluate...
Mounting evidence indicates that children who experience abuse and neglect are prone to chronic diseases premature mortality later in life. One mechanistic hypothesis for this phenomenon is early life adversity alters the expression or functioning of glucocorticoid receptor (GR) throughout course thereby increases sensitivity inflammatory stimulation. An exaggerated pro-inflammatory response generally considered be a key cause postoperative cognitive dysfunction (POCD). The aim study was...
Abstract Background Postoperative cognitive dysfunction (POCD) is a common complication after anesthesia/surgery, especially among elderly patients, and poses significant threat to their postoperative quality of life overall well-being. While it widely accepted that patients may experience POCD following the exact mechanism behind this phenomenon remains unclear. Several studies have indicated interaction between silent mating type information regulation 2 homologue 1 (SIRT1) brain-derived...
The catalytic atroposelective synthesis of axially chiral heterobiaryls was first developed through the direct one-step dynamic kinetic condensation reaction with simple transformation C═O bond to C═N bond, delivering a series novel heterobiaryl oxime ethers.
Pituitary adenylate cyclase-activating polypeptide (PACAP) is effective in reducing axonal damage associated with traumatic brain injury (TBI), and has immunomodulatory properties. Toll-like receptor 4 (TLR4) an important mediator of the innate immune response. It significantly contributes to neuroinflammation induced by injury. However, it remains unknown whether exogenous PACAP can modulate TBI through TLR4/adapter protein myeloid differentiation factor 88 (MyD88)/nuclear factor-κB (NF-κB)...
Dexmedetomidine has been reported to reduce mortality in septic rats. This study was designed investigate the effects of dexmedetomidine on inflammatory reaction lung tissues rats induced by CLP. After induction sepsis, were treated with normal saline or (5, 10, 20 μg/kg). The survival rate 24 h recorded. inflammation evaluated HE stain. concentrations IL-6 and TNF- α BALF plasma measured ELISA. expressions TLR4 MyD88 western blotting. activation NF-κB rat assessed blotting...
Background The underlying mechanisms of neuropathic pain remain unclear. This work aimed to investigate the role Sirtuin3 (SIRT3), an nicotinamide adenosine dinucleotide+-dependent histone deacetylase, in development induced by type 2 diabetes mellitus (T2DM) and explore associated mechanisms. Methods Diabetic (DNP) rats was high-fat diet/low-dose streptozotocin. behaviors were examined using von Frey Hargreaves tests. levels SIRT3, manganese superoxide dismutase (MnSOD) catalase (CAT)...
Although pain is a prevalent nonmotor symptom in Parkinson's disease (PD), it undertreated, part because of our limited understanding the underlying mechanisms. Considering that basal ganglia are implicated sensation, and their synaptic outputs controlled by subthalamic nucleus (STN), we hypothesized STN might play critical role parkinsonian hypersensitivity. To test this hypothesis, established unilateral mouse model with moderate lesions dopaminergic neurons substantia nigra. The mice...
Numerous studies have shown that mitochondrial dysfunction manifested by increased permeability transition pore (mPTP) opening and reactive oxygen species (ROS) level, decreased membrane potential (MMP) plays an important role in the development of neuropathic pain. Sirtuin3 (SIRT3), a nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylase, has been to inhibit oxidative stress. However, SIRT3 pain is unclear. In this study, we found protein mRNA levels were significantly...
Abstract Aim Repeated exposure to ketamine during the neonatal period in mice leads cognitive impairments adulthood. These are likely caused by synaptic plasticity and excitability damage. We investigated precise role of brain‐derived neurotrophic factor (BDNF) induced repeated period. Methods evaluated function using Morris water maze test novel object recognition test. Western blotting immunofluorescence were used detect protein levels BDNF. blotting, Golgi‐Cox staining, transmission...
Neuropathic pain is a type of caused by an injury or disease the somatosensory nervous system. Currently, there still absence effective therapeutic drugs for neuropathic pain, so developing new urgently needed. In present study, we observed effect Comp 6d, novel silent information regulator 1 (SIRT1) activator synthesized in our laboratory, on and investigated mechanisms involved. We found that both intrathecal intraperitoneal injections 6d effectively alleviated induced chronic constriction...
Background/Aims: Ketamine has been reported to exert anti-inflammatory effects on astrocytes stimulated by lipopolysaccharide (LPS) in vitro and vivo. However, the mechanism not elicited clearly. The aim of this study was investigate ketamine TLR4 expression NF-ĸB-p65 phosphorylation, as well production proinflammatory cytokines LPS challenged astrocytes. Methods: Astrocytes were with (1µg/ ml) absence presence various concentrations (10, 100, 1000µM). IL-1β, IL-6 TNF-α measured ELISA, glial...
Cysteinyl leukotrienes and their receptors have been shown to be involved in the generation of neuropathic pain. We performed this study determine antagonistic effect montelukast, a cysteinyl receptor antagonist, on pain its underlying mechanism.Neuropathic was induced by chronic constriction injury (CCI) sciatic nerve rats. After CCI, rats were repeatedly administered montelukast (0.5, 1.0, 2.0 mg/kg intraperitoneal, once daily) for period 14 days. Mechanical withdrawal threshold thermal...
Metal-matrix self-lubricating composites can exhibit excellent tribological properties owing to the release of solid lubricant from matrix and formation a lubricating film on tribosurface. The coverage worn surface significantly influences sliding process. However, it is difficult quantify thin discontinuous character high roughness surface. A quantitative characterization based X-ray photoelectron spectroscopy (XPS) analysis was developed in this study. friction tests Cu-MoS2 with MoS2...
Synanthropic rats and mice share the same environment with humans play an important role in epidemiology of toxoplasmosis; however, there is limited information about prevalence genetic characterization Toxoplasma gondii synanthropic China. In present study, T. naturally infected rodents (Rattus norvegicus Mus musculus) were investigated urban area Xuzhou city, Eastern China between June 2013 August 2014. DNA from brain each animal was prepared screened by specific PCR assay targeting...
Objective: Inflammation plays a key role in the etiology and pathology of postoperative cognitive dysfunction (POCD). Cyclooxygenase (COX)-2 inhibitor celecoxib is used for treatment acute pain due to its potent anti-inflammatory analgesic effects. Herein, we evaluated effects on POCD geriatric patients. Methods: A total 178 patients undergoing knee arthroplasty were randomly divided into two groups treated with (group C) or placebo P). The levels perioperative plasma COX-2, IL-1β, IL-6,...