A5100406716- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Pain Management
- Anesthesia and Sedative Agents
- Pain Mechanisms and Treatments
- Cancer Mechanisms and Therapy
- Ferroptosis and cancer prognosis
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
- Pleural and Pulmonary Diseases
- Neuropeptides and Animal Physiology
- Respiratory Support and Mechanisms
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- RNA modifications and cancer
- Mechanical Circulatory Support Devices
- Airway Management and Intubation Techniques
- Nausea and vomiting management
- Pain Management and Treatment
- Angiogenesis and VEGF in Cancer
- Acupuncture Treatment Research Studies
- Mesenchymal stem cell research
- Pain Management and Opioid Use
- Music Therapy and Health
Xuzhou Medical College
2021-2025
Xuzhou Central Hospital
2016-2025
Tianjin Medical University General Hospital
2023-2025
Zhejiang University
2025
Zhejiang Lab
2025
Second Affiliated Hospital of Zhejiang University
2025
Northwest University
2023-2024
Shanghai Skin Disease Hospital
2024
Tongji University
2006-2024
Fujian Agriculture and Forestry University
2024
Applying artificial intelligence techniques in medical imaging is one of the most promising areas medicine. However, recent success this area highly relies on large amounts carefully annotated data, whereas annotating images a costly process. In paper, we propose novel method, called FocalMix, which, to best our knowledge, first leverage advances semi-supervised learning (SSL) for 3D image detection. We conducted extensive experiments two widely used datasets lung nodule detection, LUNA16...
Mounting evidence indicates that children who experience abuse and neglect are prone to chronic diseases premature mortality later in life. One mechanistic hypothesis for this phenomenon is early life adversity alters the expression or functioning of glucocorticoid receptor (GR) throughout course thereby increases sensitivity inflammatory stimulation. An exaggerated pro-inflammatory response generally considered be a key cause postoperative cognitive dysfunction (POCD). The aim study was...
To investigate postoperative functional connectivity (FC) alterations across impaired cognitive domains and their causal relationships with systemic inflammation.Postoperative dysfunction commonly occurs after cardiac surgery, both neuroinflammation may trigger its development. Whether FC underlying deficits in specific surgery are affected by inflammation remains unclear.Seventeen patients, who underwent valve replacement, completed a neuropsychological test battery brain MRI scan before on...
The silent information regulator (Sir2) family proteins are NAD+-dependent deacetylases. Although a few substrates have been identified, functions of the bacteria Sir2-like protein (CobB) still remain unclear. Here role CobB on Escherichia coli chemotaxis was investigated. We used Western blotting and mass spectrometry to show that response CheY is substrate CobB. Surface plasmon resonance (SPR) indicated acetylation affects interaction between flagellar switch FliM. presence intact flagella...
Abstract The impact of antiangiogenic therapy on the Sp1/vascular endothelial growth factor (VEGF) pathway and that alteration Sp1 signaling efficacy is unclear, yet understanding their interactions has significant clinical implications. Treatment with bevacizumab, a neutralizing antibody against VEGF, suppressed human pancreatic cancer in nude mice. Gene expression analyses revealed this treatment substantially up-regulated its downstream target genes, including VEGF epidermal receptor,...
Responses of human mesenchymal stem cells from bone marrow (hBMSCs) were analyzed under chemical conditions, and then characterization ion channels was evaluated by whole-cell patch clamp.To explore the possibility differentiation marrow-derived into neuron-like in vitro different conditions.The generation has been studied. However, few these studies characterized functional properties differentiated hBMSCs.hBMSCs (Passage 2) expanded cultured vitro. After Passage 5 subcultured, induced...
Posttraumatic stress disorder (PTSD) is common in people who have experienced trauma, especially those hospitalized for surgery. Dexmedetomidine may reduce or reverse the early consolidation and formation of conditioned fear memory prevent occurrence postoperative PTSD. To evaluate effects intraoperative low-dose intravenous pumping dexmedetomidine on PTSD among patients with trauma undergoing emergency This double-blind, randomized clinical trial was conducted from January 22 to October 20,...
<title>Abstract</title> <bold>Chronic postsurgical pain (CPSP) is prevalent after distal lower limb fracture. To identify high-risk patients early and provide individualized treatment, we aimed to develop validate a clinical risk model that can predict CPSP in followed for at least 3 months surgery. In this retrospective cohort study, identified who required open reduction internal fixation tibial, fibular, or ankle fractures up We focused on variables accessible clinicians during the...
To observe the effect of transcutaneous electrical acupoint stimulation (TEAS) on postoperative pain in patients undergoing modified radical mastectomy for breast cancer. A total 140 female scheduled unilateral cancer general anesthesia were randomized into a TEAS group (70 cases) and sham cases, 2 cases dropped out). Patients both groups received or at bilateral Neiguan (PC6), Zusanli (ST36), Danzhong (CV17), respectively, from 30 min before induction until end surgery, 1st, 2nd, 3rd days...
Patients with colorectal cancer (CRC) harboring BRAF mutation have a poor prognosis. The median survival time for patients advanced BRAFV600E-mutant CRC is only approximately one year. Owing to the insensitivity standard chemotherapy, there are still no effective and highly specific treatment strategies available in clinical practice mutation. Therefore, targeting BRAFV600E site, researching exploring novel targeted therapies essential improve rate of this subtype. This study aims develop...
Sevoflurane, the most commonly used inhalational anesthetic, may negatively impact brain by inducing oxidative stress. This study investigated potential protective role of alpha-lipoic acid (ALA) in mitigating sevoflurane-induced stress and damage. A total 155 patients undergoing sevoflurane anesthesia for liver resection surgery were randomly assigned to receive either ALA or a placebo. Perioperative internal jugular venous blood samples collected measure markers (8-OHdG, sORP, cORP) injury...
Background Recent decades have witnessed a concerning global trend of declining engagement among physician scientists, with participation rates falling from 4.7% in the 1980s to approximately 1.5% today United States. The research highlights scientists and challenges young physicians face participating clinical research. Objective This study aims examine intrinsic motivation, attitudes, practices toward scientific its value identify factors that influence their activities. Methods We...
<sec> <title>BACKGROUND</title> Recent decades have witnessed a concerning global trend of declining engagement among physician scientists, with participation rates falling from 4.7% in the 1980s to approximately 1.5% today United States. The research highlights scientists and challenges young physicians face participating clinical research. </sec> <title>OBJECTIVE</title> This study aims examine intrinsic motivation, attitudes, practices toward scientific its value identify factors that...
Objective: Inflammation plays a key role in the etiology and pathology of postoperative cognitive dysfunction (POCD). Cyclooxygenase (COX)-2 inhibitor celecoxib is used for treatment acute pain due to its potent anti-inflammatory analgesic effects. Herein, we evaluated effects on POCD geriatric patients. Methods: A total 178 patients undergoing knee arthroplasty were randomly divided into two groups treated with (group C) or placebo P). The levels perioperative plasma COX-2, IL-1β, IL-6,...
Cytokine-like protein 1 (CYTL1) expression is deliberately downregulated during the progression of multiple types cancers, especially breast cancer. However, metabolic characteristics cancer remain unclear. Here, we uncovered a risk cells harboring low CYTL1 expression, which metabolically controlled malignant progression. We performed metabolism comparison and revealed that with have highly suppressed transsulfuration activity driven by cystathionine β-synthase (CBS) contributes to de novo...
Many annotated long noncoding RNAs (lncRNAs) contain small open reading frames (sORFs), some of which have been demonstrated to encode proteins or micropeptides with fundamental biological importance. However, functions lncRNAs-encoded in viral pathogenesis remain largely unexplored. Here, we identified a 110-amino acid protein as key regulator influenza A virus (IAV) replication. This that call PESP was encoded by the putative lncRNA PCBP1-AS1. It observed both PCBP1-AS1 and were...
Pathogenic mycobacteria transport virulence factors across their complex cell wall via a type VII secretion system (T7SS)/early secreted antigenic target-6 of kDa (ESX). ESX conserved component (Ecc) B, core the T7SS architecture, is predicted to be membrane bound protein, but little known about its structure and function. Here, we characterize EccB1, showing that it an ATPase with no sequence or structural homology other ATPases located in envelope Mycobacterium tuberculosis H37Rv. We...
Abstract Background and Purpose Osteoarthritis (OA) pain remains a major clinical problem. It is urgent to identify novel therapeutic approaches for OA states. Bromodomain extra‐terminal (BET) protein inhibitors have robust anti‐inflammatory effects in several models. However, the underlying mechanisms of these not been determined. We, therefore, investigated mechanism(s) BET inhibition on pain‐related behaviours rat model OA. Experimental Approach The was established by intra‐articular...