A5062430404- Molecular Biology Techniques and Applications
- Cancer-related molecular mechanisms research
- Genomics and Rare Diseases
- Cancer Genomics and Diagnostics
- Plant Molecular Biology Research
- Genomics and Phylogenetic Studies
- RNA modifications and cancer
- Metabolomics and Mass Spectrometry Studies
- Gene expression and cancer classification
- Bioinformatics and Genomic Networks
- MicroRNA in disease regulation
- Advanced Proteomics Techniques and Applications
- Tryptophan and brain disorders
- Mass Spectrometry Techniques and Applications
- Gut microbiota and health
- RNA Research and Splicing
- Stress Responses and Cortisol
- Plant Stress Responses and Tolerance
- Advanced Biosensing Techniques and Applications
- Ferroptosis and cancer prognosis
- Parasites and Host Interactions
- Birth, Development, and Health
- Carbon Nanotubes in Composites
- Diet and metabolism studies
- Plant nutrient uptake and metabolism
Fudan University
2014-2025
State Key Laboratory of Genetic Engineering
2015-2025
Renmin Hospital of Wuhan University
2014-2025
Wenzhou Medical University
2025
South China Normal University
2024-2025
Shanghai Stomatological Hospital
2021-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2020-2024
Chongqing Medical University
2020-2024
Beihang University
2024
Nanjing Drum Tower Hospital
2022-2024
The rat has been used extensively as a model for evaluating chemical toxicities and understanding drug mechanisms. However, its transcriptome across multiple organs, or developmental stages, not yet reported. Here we show, part of the SEQC consortium efforts, comprehensive transcriptomic BodyMap created by performing RNA-Seq on 320 samples from 11 organs both sexes juvenile, adolescent, adult aged Fischer 344 rats. We catalogue expression profiles 40,064 genes, 65,167 transcripts, 31,909...
Gene expression profiling is being widely applied in cancer research to identify biomarkers for clinical endpoint prediction. Since RNA-seq provides a powerful tool transcriptome-based applications beyond the limitations of microarrays, we sought systematically evaluate performance RNA-seq-based and microarray-based classifiers this MAQC-III/SEQC study prediction using neuroblastoma as model.We generate gene profiles from 498 primary neuroblastomas both 44 k microarrays. Characterization...
The mouse has been widely used as a model organism for studying human diseases and evaluating drug safety efficacy. Many effects exhibit tissue specificity that may be reflected by tissue-specific gene-expression profiles. Here we construct comprehensive transcriptomic BodyMap across 17 tissues of six-weeks old C57BL/6JJcl mice using RNA-seq. We find different expression patterns between protein-coding non-coding genes. Liver expressed the least complex transcriptomes, is, smallest number...
Abstract Adenocarcinoma in situ and minimally invasive adenocarcinoma are the pre-invasive forms of lung adenocarcinoma. The genomic immune profiles these lesions poorly understood. Here we report exome transcriptome sequencing 98 precursor 99 adenocarcinomas. We have identified EGFR , RBM10 BRAF ERBB2 TP53 KRAS MAP2K1 MET as significantly mutated genes pre/minimally group. Classes genome alterations that increase frequency during progression to malignancy revealed. These include mutations...
Circular RNAs (circRNAs) are essential participants in the development and progression of various malignant tumors. Previous studies have shown that cell migration-inducing protein (CEMIP) accelerates prostate cancer (PCa) anoikis resistance (AR) by activating autophagy. This study focused on effect circCEMIP PCa metastasis. gradually revealed role circ_0004585 via quantitative real-time PCR (qRT-PCR) analysis, western blotting, pull-down assays, dual fluorescence reporter assays....
Summary Celery ( Apium graveolens L. 2 n = x 22), a member of the Apiaceae family, is among most important and globally grown vegetables. Here, we report high‐quality genome sequence assembly, anchored to 11 chromosomes, with total length 3.33 Gb N50 scaffold 289.78 Mb. Most (92.91%) composed repetitive sequences, 62.12% 31 326 annotated genes confined terminal 20% chromosomes. Simultaneous bursts shared long‐terminal repeats (LTRs) in different plants suggest inter‐specific exchanges. Two...
Abstract The survival of cancer cells after detaching from the extracellular matrix (ECM) is essential for metastatic cascade. programmed cell death detachment known as anoikis, acting a metastasis barrier. However, most aggressive escape anoikis and other patterns to initiate This study revealed role migration-inducing protein (CEMIP) in autophagy modulation resistance during ECM detachment. CEMIP amplification resulted protective induction via mechanism dependent on dissociation B-cell...
Characterization and integration of the genome, epigenome, transcriptome, proteome metabolome different datasets is difficult owing to a lack ground truth. Here we develop characterize suites publicly available multi-omics reference materials matched DNA, RNA, protein metabolites derived from immortalized cell lines family quartet parents monozygotic twin daughters. These references provide built-in truth defined by relationships among members information flow DNA RNA protein. We demonstrate...
Batch effects are notoriously common technical variations in multiomics data and may result misleading outcomes if uncorrected or over-corrected. A plethora of batch-effect correction algorithms proposed to facilitate integration. However, their respective advantages limitations not adequately assessed terms omics types, the performance metrics, application scenarios.
Abstract Eggs produced by the mature female parasite are responsible for pathogenesis and transmission of schistosomiasis. Female schistosomes rely on a unique male-induced strategy to accomplish reproductive development, process that is incompletely understood. Here we map detailed transcriptomic profiles male Schistosoma japonicum across eight time points throughout sexual developmental from pairing maturation. The dynamic gene expression pattern data reveal clear sex-related...
MicroRNAs (miRNAs) play a critical role in responses to biotic and abiotic stress have been characterized large number of plant species. Although flax (Linum usitatissimum L.) is one the most important fiber oil crops worldwide, no reports published describing miRNAs (Lus-miRNAs) induced response saline, alkaline, saline-alkaline stresses. In this work, combined small RNA degradome deep sequencing was used analyze libraries constructed after alkaline-salt (AS2), neutral salt (NSS), alkaline...
Abstract The remarkable advances in next-generation sequencing technology have enabled the wide usage of as a clinical tool. To promote advance precision oncology for breast cancer China, here we report large-scale prospective program using Fudan-BC panel, and comprehensively analyze genomic characteristics Chinese cancer. mutational landscape 1,134 cancers reveals that most significant differences between Western patients occurred hormone receptor positive, human epidermal growth factor 2...
BACKGROUND Diabetic nephropathy (DN), which is one of the primary causes end-stage renal disease (ESRD), increasingly diagnosed in patients due to continuous increase prevalence diabetic mellitus (DM). Astragali Radix, a traditional Chinese herb, widely administrated ameliorate symptoms diabetes and nephropathy, but its mechanism still not yet fully defined. Calycosin (C₁₆H₁₂O₅) major active component Radix. In this study, we analyzed role calycosin explored underlying mechanism. MATERIAL...